Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Deep lung pulmonary delivery of treprostinil

A technology of treprostinil and lung deposition, applied in the field of lung delivery, can solve the problem of not providing sustained drug release, and achieve the effect of increasing efficacy

Inactive Publication Date: 2011-08-24
ARADIGM
View PDF21 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Further, a potential problem may be that the inhaled dosage form does not provide any sustained release of the drug over time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Deep lung pulmonary delivery of treprostinil
  • Deep lung pulmonary delivery of treprostinil
  • Deep lung pulmonary delivery of treprostinil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] 9. Research plan

[0074] 9.1 General study design and plan

[0075] This was a single-centre, open-label study using a randomized two-way crossover design. Sixteen healthy adult male subjects participated and received study treatment. After providing written informed consent, each study candidate underwent a pre-study assessment and screening to determine eligibility for participation.

[0076] Subjects were instructed and trained in the proper use of the Nebu-Tec Optineb Nebulizer and the use of the drug-free AERx Essence System.

[0077] On each of the two dosing days, eligible subjects administered either the AERx Essence System or the Nebu-Tec Optineb Nebulizer 99m Administration of Tc-labeled treprostinil sodium. Following the initial study dose, subjects underwent a washout period of approximately 48 hours before completing the second (crossover) study dose.

[0078] Following each study dose, subjects underwent gamma scintigraphy and multiple venous blood s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
diameteraaaaaaaaaa
diameteraaaaaaaaaa
Login to View More

Abstract

Administration of aerosolized Treprostinil formulations may provide a more homogeneous lung deposition of treprostinil, whereby making deep lung delivery possible.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to US Provisional Patent Application Serial No. 61 / 100,017, filed September 25, 2009, which is incorporated herein by reference. technical field [0003] The present application relates generally to methods of treatment and, in particular, to methods of treatment which may include pulmonary delivery of inhaled compounds. Such pulmonary delivery can reduce dosage, side effect spectrum and / or frequency of administration. Additionally, such delivery may provide a depot effect in the peripheral lung and an associated extended release into the systemic circulation. Background technique [0004] Most medications can generally be administered by some type of injection. While injecting medication can offer many advantages, it can sometimes be inconvenient and / or painful for some patients. One class of drugs typically administered by injection is prostacyclins and their analogs, eg Treprostin...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A01N37/10A01K31/19
CPCA61K9/0078A61K31/191A61P11/00A61P11/08A61P13/12A61P15/00A61P17/00A61P17/06A61P29/00A61P35/00A61P43/00A61P7/02A61P9/04A61P9/10A61P9/12A61K9/12A61K31/192
Inventor 戴维·C··奇波拉伊戈尔·贡达通德·奥图拉纳理查德·莫里希盖保罗·布鲁内恩贝尔格
Owner ARADIGM
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com