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In-vitro simulation analysis system and method for PBDD/Fs in atmospheric particulates

An atmospheric particulate matter, in vitro simulation technology, applied in the field of inhalation bioavailability analysis, can solve problems such as overestimating the health risk of PBDD/Fs, and achieve the effect of simple and easy-to-obtain detection system, convenient operation, and guaranteed accuracy

Active Publication Date: 2022-01-28
HEBEI UNIVERSITY
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Problems solved by technology

At present, in actual research, the assessment of PBDD / Fs on human respiratory exposure is mainly based on the total concentration of PBDD / Fs in the atmosphere, that is, it is assumed that all (100%) of PBDD / Fs carried by particulate matter can enter the body fluid circulation or target organs. Health risks of PBDD / Fs exposure may be overestimated

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  • In-vitro simulation analysis system and method for PBDD/Fs in atmospheric particulates

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Embodiment Construction

[0032] The present invention will be further elaborated below in conjunction with the examples, the process and method not described in detail in the following examples are conventional methods known in the art, and the raw materials or reagents used in the examples are commercially available unless otherwise specified. Purchased through commercial channels.

[0033] The detection system of the present invention is as figure 1 As shown, it includes a screw-top reagent bottle, a centrifuge tube with a sieve plate at the bottom, and a semi-permeable membrane bag. The bag is used to hold the quartz fiber membrane adsorbed with atmospheric particles, the centrifuge tube is placed in the simulated lung fluid of the reagent bottle, and the semipermeable membrane bag is placed in the Tenax adsorbent of the centrifuge tube. The semipermeable membrane is clamped at both ends with clamps.

[0034] Applying the above-mentioned system for in vitro simulation analysis includes the follow...

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Abstract

The invention provides an in-vitro simulation analysis system and method for PBDD / Fs in atmospheric particulates. The method comprises the following steps: (a) collecting an atmospheric particulate sample by using an atmospheric particulate sampler and a quartz fiber membrane, and analyzing the content of PBDD / Fs in the atmospheric particulate sample; (b) cutting the quartz fiber membrane into pieces, respectively putting the quartz fiber membrane pieces into a semi-permeable membrane bag, adding a Tenax adsorbent into a centrifugal tube, respectively adding an ALF simulation lung fluid and a GS simulation lung fluid into reagent bottles, and carrying out an in-vitro simulation experiment; (c) detecting the content of PBDD / Fs in the Tenax adsorbent and the simulation lung fluid; and (d) considering the lung deposition efficiency of atmospheric particulates, and evaluating the inhalation bioaccessibility of the carrier PBDD / Fs. According to the invention, the inhalation bioaccessibility of PBDD / Fs can be conveniently obtained, and the method has important significance for accurately evaluating the respiratory exposure risk of people with the PBDD / Fs in the particulate matters.

Description

technical field [0001] The invention relates to the analysis field of inhalation bioavailability of PBDD / Fs carried by atmospheric particulates, in particular to an in vitro simulation analysis system and method for PBDD / Fs in atmospheric particulates. Background technique [0002] Brominated dioxins (Polybrominated dibenzo-p-dioxins and polybrominated dibenzofurans, PBDD / Fs) have similar physical and chemical properties to chlorinated dioxins, and their chemical structures are shown in formula 1. Abbreviation for brominated aromatic heterocyclic compounds of oxygen tricyclic rings, including polybrominated dibenzo-p-dioxins (Polybrominated dibenzo-p-dioxins, PBDDs) and polybrominated dibenzofurans (polybrominated dibenzofurans, PBDFs) ). PBDD / Fs comes from a wide range of sources, mainly in the production, use and recycling of brominated flame retardants and products containing brominated flame retardants, as well as thermal processing and treatment processes such as elect...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N15/00G01N15/04
CPCG01N15/00G01N15/04
Inventor 张宪林佳旭高俊楠李林森尹明远牛璨
Owner HEBEI UNIVERSITY
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