179 results about "Ion pairing" patented technology

The present disclosure generally relates to compositions, and related devices and methods, useful in vaporizing devices such as electronic cigarettes. The composition may comprise nicotine, at least one solvent, and at least one ion pairing agent, and may be vaporized to form a condensation aerosol, wherein inhalation of the aerosol allows for deposition of nicotine with the respiratory system, including deep lung deposition. The vaporizing device may comprise a vaporization unit, a battery, and an integrated circuit coupled to the battery, wherein the integrated circuit is configured to control the battery for rapid initial vaporization without overheating, producing thermal degradation products, or draining battery energy. The battery may operate with pulse width modulation for at least a portion of the time the vaporizing device is being used.

The patch preparation of the present invention is a patch preparation comprising a backing and an adhesive layer provided on the backing; wherein, the adhesive layer contains (A) a volatile organic acid and (B) a basic drug; the molar concentration ratio [(M_A)/(M_B)] between the molar concentration (M_A) of the component (A) and the molar concentration (M_B) of the component (B) in the adhesive layer is 0.5 or more; and the component (B) contains a basic drug formed as an ion pair with an anion component.

This invention relates to a novel ion-pair delivery system useful for gender and ethnic background selective hair care and nail care applications in which an electron donor composition and an electron acceptor composition, or a proton donor composition and a proton acceptor composition, or an anionic and a cationic composition, are combined synergistically. The bioavailability, deposition, functional performance, and consumer aesthetics of the compositions thus combined in such ion-pairs are enhanced synergistically. Hair care compositions, such as shampoo, conditioner, hair lotion, hair oil, hair gel, hair sheen, hair rinse, hair balm, hair wax, hair spray, and such, and nail care compositions, such as nail enamel, nail creams, nail serums, nail lacquers, nail spray, and nail polish, and such, can thus be obtained with synergistically enhanced performance.

The invention discloses a method for detecting multiple lipid-soluble vitamins in a blood sample simultaneously. The method comprises the steps of preprocessing a biological sample by a simple liquid-liquid extraction method, then carrying out chromatographic separation and mass spectrometric detection, respectively selecting a pair of qualitative ions and a pair of quantitative ions according to each vitamin, wherein the relative retention time and qualitative ion pairs of the various vitamins are taken as qualitative basis, and a standard curve for quantitation is formed by standard substances. Meanwhile, according to the method, three levels of quality control substances are used for inspecting the accuracy and effectiveness of the method, and the distortion of the detection result is avoided. According to the method, the purpose that six lipid-soluble vitamins in one serum sample can be simultaneously detected can be realized for the first time by applying an LC-MS technology, the influence caused by interferents can be alleviated, the operation is simple, convenient and rapid, the analysis time is only 4.8min, the throughput is high, the cost is low, the levels of lipid-soluble vitamins in a human body are effectively monitored, and the method has guiding significance on the reasonable and safe supplementation of vitamins, and is liable to clinical promotion and popularization.

A light-emitting polymer composition comprising a light-emitting polymer and an ion pair, wherein the ion pair has a negative ion of a specific structure in which one group 13 atom and is bonding to an aryl group having an electron-withdrawing group, or a heterocyclic group having an electron-withdrawing group, directly or through a connecting group; or two or more group 13 atoms, and all the atoms are respectively bonding to an aryl group having an electron-withdrawing group, or a heterocyclic group having an electron-withdrawing group, directly or through a connecting group.

The present invention provides an ion pair compound of the formula [narcotic]⁺[A]⁻, wherein [narcotic]⁺ represents at least one cation of at least one narcotic agent or one or more stereochemical isomers thereof and [A]⁻ represents at least one anion of at least one NSAID or one or more stereochemical isomers thereof. An example of the ion pair compound is propoxyphene diclofenate. The ion pair compounds, or their pharmaceutical compositions, are useful in methods of treating a wide variety of conditions that indicate analgesics, anti-inflammatory agents, or both. Under the conditions prescribed for their use, the ion pair compounds exhibit poor or complete insolubility but excellent chemical stability in low pH environments, such as those found in the stomach. The ion pair compounds readily dissolve and dissociate in higher pH environments such as the small intestine to release the constituent narcotic and NSAID.

Disclosed is a metal pattern composition including a conductive metal or a conductive metal precursor compound, and a carboxylic acid-amine base ion pair salt.

The present invention relates to a cosmetic or pharmaceutical composition to reduce skin damage caused by aging and/or the environment. The composition can include a genus Centipeda plant extract, a trace metal source in a skin absorbing form in an amount effective for activating or enhancing superoxide dismutase enzyme, and a carrier suitable for topical administration. The compound may alternatively include a genus Centipeda plant extract and a low molecular weight transporter and an ion-pair delivery system including a donating composition and an accepting composition, wherein the donating composition and the accepting composition are combined to form a bound ion-pair, and a carrier suitable for topical administration.

A process for producing an olefin polymer is provided, in which ethylene and at least one kind or more of monomers selected from α-olefins are polymerized by a high temperature solution polymerization in a temperature range between 120 and 300° C., in the presence of an olefin polymerization catalyst composed of a bridged metallocene compound represented by general formula [I] described below and at least one kind or more compounds (B) selected from (b-1) an organoaluminum oxy-compound, (b-2) a compound capable of forming an ion pair in a reaction with the bridged metallocene compound mentioned above, and (b-3) an organoaluminum compound. According to the high temperature solution polymerization of the present invention, it has become possible to obtain a polymer having a high molecular weight with high polymerization activity that was so far unattainable, and when the polymer is a copolymer, it is a process for producing a high molecular weight olefin polymer with a large comonomer content, a narrow composition distribution, and a narrow molecular weight distribution.

The invention discloses a method for measuring blood concentration of paraquat. The method comprises the following steps of: (1) pretreating a sample, namely adding aqueous solution of an internal standard substance and a protein precipitation agent acetonitrile into a plasma sample, performing whirl mixing, centrifuging and sampling supernatant; (2) separating the sample, namely adopting a universal C18 liquid chromatographic column, and using an ion pairing agent in an acid mobile phase, wherein the acid mobile phase is mixed solution of 3mmol.L<-1> aqueous solution of sodium dodecyl sulfate, 0.2 percent of aqueous solution of trifluoroacetic acid, acetonitrile and water; and (3) detecting by using a diode array detector, namely detecting by using the diode array detector at a detectionwavelength of 250 to 260nm, measuring peak areas of the internal standard substance and the paraquat, and calculating the blood concentration of the paraquat through least square method linear regression. The plasma sample is easy and convenient to pretreat, the detection process is sensitive and rapid, toxic substances and the blood concentration thereof can be rapidly determined in actual application, and the method is high in clinical application value.

Embodiments of the present invention provide a method of chromatographic delipidation comprising separating a lipid-containing sample on a superficially porous stationary phase at greater than about 70° C., at least about 80° C., having at least one mobile phase comprising an ion-pairing agent in water, an ion-pairing agent in an organic modifier, an acid in an organic modifier, and an alcohol. The invention provides minimal protein losses and high run-to-run reproducibility. The on-column delipidation method aventageously utilize reversed phase liquid chromatography.

The invention discloses a detection method of nitrate and nitrite in blood, urine and tissue. In the weak acidic condition, nitrate ions and an ion pair reagent form an ion pair, and nitrite and a Griess reagent are reacted for a diazotization coupling reaction for forming an azo compound, thereby nitrate and nitrite which can not be retained on the chromatographic column without UV absorption can be analyzed by liquid chromatogram at different wavelengths, and mutual interferences are eliminated. The nitrate and nitrite detection in blood, urine and tissue which have large matrix interferences and low contents have larger applicability, and the detection limit of nitrate and nitrite are 0.2 mu g/mL and 0.05 mu g/mL respectively. The invention has the characteristics of simple operation, rapid determination, efficiency, accuracy, etc.

The invention discloses a moisture power generation method and device. The method includes the following steps: pouring a polymer solution into a culture dish and then placing the culture dish in a drying oven to prepare a polymer power generation film; placing the polymer power generation film on a moisture-insulated metal electrode, and disposing a porous top electrode above the polymer power generation film to protect a film form of the polymer power generation film and to transmit moisture; applying moisture stimulation to an external single direction of the metal electrode to induce separation of positive and negative ion pairs in the polymer power generation film and to release freely moving current carriers; and diffusing from a high concentration area to a low concentration area bythe current carriers to generate a potential difference and an electric current, thereby outputting electric energy to the outside. The method adopts a polymer material which is simple and easy to obtain and can be bent, stretched or even self-repaired, can achieve moisture control by simultaneously using orientation moisture stimulation, does not require usage of high-cost lasers, is simple in test method, does not require usage of other expensive external equipment for a test process, and has the advantage of large-scale integration.

There is provided a method for forming an aluminide coating on a surface of a heat resistant superalloy substrate, comprising the steps of: exposing a base metal of the substrate in a selective area; forming a aluminum or an aluminum alloy film on the exposed base metal, by a non-aqueous electroplating; and conducting a heat treatment to the substrate on which the film is formed, in order to make a diffusion reaction between an aluminum component in the film and the base metal, and form the aluminide coating, wherein: there is used, as a plating liquid, a non-aqueous plating liquid containing a halide of the metal to be plated and an organic compound which forms an ion pair with the metal halide; and the electroplating is conducted by immersing the selective area into the plating liquid through the use of predetermined means for shielding the plating liquid from the atmosphere.

The invention relates to a purifying method for terlipressin. The method is characterized by comprising the following steps: step 1, dissolving a crude terlipressin product with water and adjusting a pH value to 3 to 4; step 2, flushing a C18 reversed-phase filled column by using an ion pair mobile phase A containing surfactant; step 3, loading a solution obtained in the step 1 into a C18 reversed-phase filling material; step 4, carrying out gradient procedures, wherein the initial-state mobile phase B of an elution gradient is 5% which is maintained for 5 min, then the proportion of the mobile phase B is increased to 30% within 60 min, and a part of target peak elution fraction is collected; and step 5, carrying out nanofiltration membrane desalination and then freeze drying so as to obtain pure terlipressin.

The invention belongs to the field of medicament analysis and particularly relates to a detection method and a content determining method for sodium calcium edetate as an accessory in pantoprazole sodium for injecting. The invention aims at solving the technical problem of providing a method with the advantages of simpleness in and convenience for operation, quickness and accuracy for detecting the sodium calcium edetate as the accessory in the pantoprazole sodium for injecting. HPLC (High Performance Liquid Chromatography) detection conditions are as follows: a stationary phase: octadecylsilane bonded silica gel is used as a filling agent; a mobile phase: in terms of volume, an ion pair buffer solution is 85-95 percent, acetonitrile is 5-15 percent and the pH value is adjusted to 2.2-2.6 with phosphoric acid; the flowing speed is 0.8-1.2 ml/min; the column temperature is 30-40DEG C; the detection wavelength is 250-260 nm; and the theoretical plate number is required not to be lower than 2000 calculated in terms of a sodium calcium edetate peak. The detection method has the advantages of simple and convenient operation, accurate and reliable determination result, stronger specificity and shorter detection time; and the retention time of a main peak is about 6 minutes.

The invention discloses a hybridized amphoteric ion membrane containing different acid gene and the method for preparing the same. The method comprises oxiding or sulfonating hybridized membrane to make membrane contain one acid gene, then ionizing said membrane to make it contain another different acid gene and amphiprotic ion pair, finally getting said product. The different acid genes in membrane are arranged on two sides of molecular chain, anion communication gene is connected to molecular main chain to form asymmetric molecular structure. The exchange capacity of zwitterions is reduced with increasement of heat treatment temperture and membrane coating number; the heat-resistance of membrane is good. The product can be used for separation, grading and compression of biological macromolecular, separation of electrolyte and non-electrolyte, and selective separation of a plurality of ions. The invention employs nontoxic inner ester as ionization agent, and oxidation and sulfonation to converse acid gene. The process is safe and clean.

The invention discloses a determination method of a perfluorinated compound isomer in soil and/or plants. The method comprises the following steps: (1) extracting a soil and/or plant sample with an ion pair extraction method; (2) concentrating and purifying an extracting solution obtained by the step (1); and (3) detecting a product of the step (2) with an ultra performance liquid chromatography-triple quadrupole tandem mass spectrometer, and comparing the product with an isomer standard product of parallel operation; and quantifying by adopting an internal standard method to obtain the content of each isomer of a perfluorinated compound. The determination method disclosed by the invention is accurate in detection result and has the advantages of high recycling rate, low detection limit, high sensitivity and strong matrix interference resisting capability.

The present invention provides a sensitive and robust analytical approach to identifying and quantifying multiple pathogens within a single complex environmental sample. Numerous nucleic acid signatures may be screened and quantified within a single reaction tube using polymerase chain reaction (PCR) and chromatographically analyzing the amplification products with microchannel fluidic (e.g. Agilent 2100 Bioanalyzer, or Caliper AMS-90) or reverse-phase ion-pairing high-performance liquid chromatography RP IP HPLC (e.g. Transgenomic WAVE) instruments. The method may be employed in a multiplex fashion to allow identification and quantification of multiple combinations of up to five different nucleic acid signatures simultaneously within a single multiplex PCR reaction tube. This approach is quantitative across a dynamic range of up to five orders of magnitude. This method is suitable for target nucleic acid analysis in medium or high-throughput contexts such as routine clinical diagnotics or environmental monitoring. The method is also suitable for pathogen monitoring or surveillance in a biodefense context.

The invention relates to an antistatic release agent comprising: a release component that contains a condensation-curing type organopolysiloxane, a conductive component that contains a complex of a π-conjugated electrically conductive polymer and a polyanion and an organic solvent, wherein the amount of the conductive component relative to 100 parts by mass of the release component is 1 to 300 parts by mass, at least one amine-type compound selected from the group consisting of a secondary amine, a tertiary amine or a quaternary ammonium salt is coordinated to or bonded to portion of anion groups in the polyanion as an ion pair, and the amine-type compound has one or more substituent selected from the group consisting of an alkyl group having 4 or more carbon atoms, an aryl group, an aralkyl group, an alkylene group, an arylene group, an aralkylene group and an oxyalkylene group.