139 results about "Ion pairing" patented technology

The invention provides a liposome preparation and a preparation method thereof, the liposome preparation comprises an ion pairing agent, phospholipid or a derivative thereof, sterol, a lipid molecule derivative and a drug compound, the ion pairing agent comprises at least one of a compound (I) and a compound (II), and the compound (II) comprises at least one of a compound (III) and a compound (III). Structures in the compound (I) and the compound (II) contain a plurality of functional groups (such as amide, carbonyl, thioether and the like), so that abundant binding sites are provided for drug molecules, and the compound (I) and the compound (II) can interact with different types of drug compounds (such as fat-soluble and water-soluble drugs); the liposome preparation is allowed to be combined with various drug molecules through hydrogen bonds, hydrophobic interaction or electrostatic interaction, and the liposome preparation adapts to physicochemical properties of different drugs. The compound (I) and the compound (II) further comprise different hydrophobic groups (such as alkyl chains) and hydrophilic groups (such as sulfonic acid, carboxylic acid and the like), so that the liposome preparation has the amphiphilic characteristic, not only can encapsulate hydrophobic drugs, but also can encapsulate hydrophilic drugs, and the variety and range of encapsulated drugs are improved.

The invention relates to the technical field of electrical performance research of insulating materials, and discloses a simulation method and system for surface charges of a basin-type insulator, a terminal and a medium, and the method comprises the steps: building a simulation model for the surface charges of the basin-type insulator through obtaining dark current data of a gas side; the gas side dark current data are set as boundary conditions of a basin-type insulator surface charge simulation model physical field, surface charge distribution characteristic calculation under any gas and gas pressure is achieved, and the method is not limited by the problem that diffusion coefficients, recombination coefficients, ion pair generation rates and migration coefficient parameters of positive and negative ions of existing gas are limited; the physical field calculation model is solved according to boundary conditions in the divided adaptive grid division, charge distribution and electric field distribution characteristics are obtained, basin-type insulator surface charge simulation is completed, the calculation efficiency is improved, and the accuracy of simulation of the surface charge distribution characteristics and spatio-temporal evolution laws of key insulators in direct-current GIS / GIL is improved.

The present disclosure provides systems and methods for separating and characterizing oligonucleotides. Fixed dose combinations of small interfering RNAs can be subjected to denaturing ion pairing reverse phase liquid chromatography using optimal conditions to separate single RNA strands for purity analysis.

The invention provides a method for detecting PFAS based on a three-dimensional Ag / NiFe-LDHs surface enhanced Raman scattering substrate and ion pair extraction, and belongs to the technical field of PFAS detection.The method comprises the steps that firstly, the three-dimensional Ag / NiFe-LDHs SERS substrate is prepared, then ion pair extraction-dissociation treatment is conducted on a water sample to be detected, a detection solution is obtained, finally, the substrate is immersed in the detection solution for adsorption, and finally the detection solution is obtained. A spectrum is collected through a Raman spectrometer, and semi-quantitative detection of PFAS in a water sample is achieved according to the linear relation between the characteristic peak intensity and the PFAS molar concentration logarithm. According to the method, collaborative application of the three-dimensional Ag / NiFe-LDHs SERS substrate and an ion pair extraction technology and indirect detection of PFAS are realized, the detection difficulty that PFAS Raman signals are weak and are difficult to enrich is improved, the detection sensitivity and adaptability of PFAS in a water sample are improved, and an application foundation is laid for rapid monitoring of PFAS pollution of an environmental water body.

A system, method, and computer program product for predicting properties of electrolytes in a liquid electrolyte mixture independent of empirical fitting from experimentally measured properties. An example aspect is configured to: validate at least one molecular force field, prepare a liquid electrolyte mixture corresponding to the at least one molecular force field, perform molecular dynamic simulations of the electrolyte mixture, obtain simulated molecular dynamic trajectories from the molecular dynamic simulations, and perform molecular structure analysis to predict ionic conductivity, ion pairing properties, solubility properties, and / or other thermodynamic properties of the liquid electrolyte mixture.

The invention discloses an ion-electron mixed conductor material and a preparation method and application thereof. The ion-electron mixed conductor material is prepared by doping a heterovalent transition metal element ion pair in a solid electrolyte. The different-valence transition metal element ion pairs comprise same transition metal elements with different valence states or different transition metal elements with different valence states; the solid electrolyte is halide solid electrolyte. Wherein the solid electrolyte structure provides a lithium ion transmission channel, and the transition metal element is rapidly oxidized and reduced to provide an electron transmission channel. The ion-electron mixed conductor is applied to a composite positive electrode of a solid-state battery, can simultaneously transmit lithium ions and electrons, shortens the transmission paths of the lithium ions and the electrons, remarkably improves the content of positive electrode active substances, improves the cycling stability of the solid-state battery, and has a relatively good application prospect in the solid-state battery.

Provided herein are methods of separating molecular species of a guanine-rich oligonucleotide from a mixture of molecular species, wherein at least one molecular species of the mixture is a quadruplex formed from the guanine-rich oligonucleotide. In exemplary embodiments, the methods comprise (a) applying the mixture to a chromatographic matrix comprising a hydrophobic ligand, wherein said hydrophobic ligand comprises C4 to C8 alkyl chains, wherein molecular species bind to the hydrophobic ligand and (b) applying a mobile phase which comprises a gradient of acetate and a gradient of acetonitrile but no cationic ion pairing agent to the chromatographic matrix to elute molecular species of the guanine-rich oligonucleotide. In exemplary aspects, the guamne-rich oligonucleotide elutes in a first set of elution fractions and a quadruplex formed from the guanine-rich oligonucleotide elutes in a second set of elution fractions.

Methods for encapsulating water-soluble biologic and small molecule active pharmaceutical ingredients (APIs) into nanoparticles by applying nanoprecipitation techniques and ion-pairing the nanoparticles with hydrophobic counterions to produce new API salts that exhibit altered solubilities are presented.

The low-pressure ionization chamber comprises a closed chamber, a low-pressure environment lower than the standard atmospheric pressure is formed in the closed chamber, and an electrode plate assembly is arranged in the closed chamber to collect electron-ion pairs in the closed chamber in the low-pressure environment; by arranging the negative-pressure closed chamber, the air density is reduced under the condition of low air pressure, so that the number of gas molecules in unit volume is reduced, the total number of charges generated by radiation ionization of a gas medium is reduced, and then the charge density and the ion recombination probability are reduced, so that the saturation characteristic of the ionization chamber is influenced.

The invention discloses a chiral alpha-amino acid with a C3 symmetric structure and a preparation method and application thereof, the chiral alpha-amino acid with the C3 symmetric structure provided by the invention is used as an ion pair catalyst, and the structure of the chiral alpha-amino acid with the C3 symmetric structure is more stable than that of other ion pair catalysts due to the C3 symmetric structure; and meanwhile, the chiral phosphamide compound is successfully constructed with relatively high yield (70-80%) and enantioselectivity (80-95%), so that the chiral phosphamide compound has excellent catalytic performance, and the problem that the chiral phosphamide compound is difficult to construct by a traditional ion pair catalyst is solved.

The present invention belongs to the field of medicinal chemistry and specifically discloses a light-responsive ion pair composition and its anti-cancer application. The ion pair composition includes a cyclometallic gold (III) complex and a photosensitizer, wherein the photosensitizer includes eosin (EY) or rose bengal (RB), and the structural formula of the cyclometallic gold (III) complex is shown in formula (1). The composition modifies the structure of the known cyclometallic gold (III) complex skeleton by adding hydroxyl groups, morpholine rings and deuteration, thereby improving its water solubility, charge properties, stability and other aspects. It can be efficiently activated by green light or even red light and has anti-cancer applications. The present invention achieves efficient activation of the cyclometallic gold (III) complex by combining the cyclometallic gold (III) complex with eosin (EY) or rose bengal (RB), and can extend the excitation wavelength to the red light range; and based on the ion pair properties and the characteristics of the tumor microenvironment, tumor-specific treatment can be achieved more accurately on the basis of light irradiation.

The invention provides a latent accelerator based on anhydride-tertiary amine dynamic ion pairs as well as a preparation method and application of the latent accelerator. The latent accelerator is a reaction product of a first component and a second component, the first component comprises a substance with an acid anhydride structure, the second component comprises a compound with a tertiary amine structure, and the latent accelerator has an acid anhydride-tertiary amine dynamic ion pair. The latent accelerator provided by the invention can realize long-term storage and medium and low temperature curing of a single-component thermosetting material, and is particularly applied to an epoxy-anhydride system, an epoxy-phenolic aldehyde system, an epoxy-dicyandiamide system, an epoxy-mercaptan system, an epoxy-hydrazide system, an epoxy-4, 4 '-dihydroxybenzenesulfonic acid system, a curing agent and a curing agent. When being used in epoxy resin systems such as 4, 4 '-diaminodiphenyl sulfone systems, the curing temperature of the epoxy resin systems can be reduced, and the epoxy resin systems can be stored for a long time.

The invention relates to the technical field of electrochemical energy storage materials, and discloses a high-ionic-conductivity eutectic gel electrolyte and a preparation method thereof. The preparation method comprises the following steps: constructing a functional element precursor of sodium lignin sulfonate and histidine hydrochloride; inducing the sodium lignin sulfonate conformation to unfold and form an ion pair cluster in an acrylic monomer through hot shear stirring; the preparation method comprises the following steps: preparing a precursor, preparing a polyvinyl alcohol skeleton solution, mixing the polyvinyl alcohol skeleton solution with the precursor, introducing layered graphite, carrying out water bath heating, stirring and dispersing, and carrying out in-situ polymerization to form a gel electrolyte with a dual-network interpenetrating structure. And the dependence of ion transmission on free water is reduced, so that the gel electrolyte has high mechanical strength, excellent ionic conductivity and interface stability are realized, and zinc dendrite growth and side reaction are inhibited.

The invention firstly provides a phosphoric acid stable type high-temperature proton exchange membrane with amphiphilic polybenzimidazole and azide type ionic liquid, the ionic liquid in the composite membrane accounts for 30% by mass, and the prepared OHPBI-PIL-Px membrane exchanges anions into H2PO4 <-> through acid-base doping reaction, so that ion pairs are formed, and the proton exchange membrane has the advantages of high-temperature proton exchange, high-temperature proton exchange, high-temperature proton exchange and the like. The composite membrane constructs a proton transfer channel in a system, promotes proton transfer and transfer, provides alkaline quaternary ammonium sites, has strong acid-base interaction with PA, and can effectively reduce PA leakage. The long-term performance of the high-temperature proton exchange membrane can be enhanced. The invention further provides a preparation method of the stable high-temperature proton exchange membrane with the amphiphilic polybenzimidazole and azide ionic liquid phosphoric acid. The OHPBI-PIL-Px membrane is formed by crosslinking through an in-situ free radical polymerization method. The formed high-temperature proton exchange membrane is excellent in electrochemical performance and controllable in cost, has a production prospect and can be applied to the field of high-temperature proton exchange membrane fuel cells.

The invention discloses a method for improving ion pair reversed-phase liquid chromatography separation by using inert gas atmosphere protection and a chromatographic instrument mobile phase management system, and aims to prevent oxidation denaturation of an ion pair reagent in a mobile phase by using inert gas and prolong the service life of the mobile phase so as to improve the stability and reproducibility of the method. The method comprises the following steps: carrying out headspace replacement on a container filled with a mobile phase by using inert gas, pre-filling the inert gas protection box by using the inert gas, placing the container filled with the mobile phase in the inert gas protection box, carrying out sealed storage, and carrying out small-amount timed supplement on the inert gas protection box by using the inert gas. The method disclosed by the invention can be applied to reversed-phase liquid chromatography separation of a mobile phase added with an ion pair reagent and qualitative and quantitative analysis of combination of the reversed-phase liquid chromatography separation and an optical detector or a mass spectrum; after the method provided by the invention is used, the reproducibility and the stability of each analysis result are remarkably improved.

Disclosed is an electrolyte comprising: a first salt, wherein the first salt is an active material salt; a second salt; and a solvent, wherein the first salt and the second salt are dissolved in the solvent, such that the dissolved first salt has a solvation structure; wherein a solubility of the first salt in the solvent is greater than about 2 M; wherein the second salt is different from the first salt and has a solubility in the solvent lower than about 2 M; wherein the second salt behaves as a diluent and is at least partially incorporated into the solvation structure; such that the solvation structure is substantially dominated by a plurality of solvent-separated pairs, contact-ion pairs, aggregates or a combination thereof. Also disclosed are electrochemical cells comprising such electrolytes. Also disclosed are methods of making the disclosed herein electrolytes and electrochemical cells.

The invention discloses a method for enhancing up-conversion avalanche nonlinearity based on metal ion regulation sublattice, which comprises the following steps: S1, selecting crystal matrix doped up-conversion avalanche activator ions as activation ions for realizing up-conversion avalanche nonlinearity; s2, co-doping one or more non-luminous metal ions on the basis of the activator ion-doped crystal matrix obtained in the S1 to replace matrix cations in the crystal matrix so as to complete sublattice shrinkage; s3, sublattice shrinkage in S2 acts on activating agent ions, so that the average physical distance of activating agent ion pairs in the system is shortened, and the efficiency of a specific cross relaxation process beneficial to upconversion avalanche nonlinearity is improved by shortening the ion spacing. Compared with the prior art, the method has the advantages that the population rate of a key intermediate energy level is enhanced, so that avalanche nonlinearity of up-conversion emission is greatly improved in a measurable manner, and the limitation of traditional up-conversion energy transfer efficiency and avalanche nonlinearity regulation is broken through.

The present application relates to the technical field of pharmaceutical analysis, and specifically discloses a method for detecting the purity of doxycycline for injection. The present application mainly solves the problems caused by ion pair reagent and high-salt buffer in the existing chromatographic method, such as serious pollution of the system pipeline and the chromatographic column, difficulty in connecting with mass spectrometry for impurity structure identification, and insufficient separation degree of key polar impurities such as 4-epi doxycycline. The present application purifies the sample by physical dilution and filtration, and prepares uniform aerosol by ultrasonic atomization. The ion mobility spectrometry technology is adopted to realize the efficient separation of gas-phase ions under a weak electric field according to the difference in ion collision cross section (CCS) value, and the epimer which is difficult to distinguish by traditional methods can be excellently separated. The multi-modal sensor is used to synchronously collect ultraviolet, fluorescent and terahertz multi-dimensional optical signals. Finally, based on the intrinsic physical parameter database, the intelligent analysis is carried out by using the machine learning algorithm, and the qualitative and quantitative results are automatically output.

The invention discloses high-dielectric-constant polyurethane with a side chain containing zwitter-ion pairs as well as preparation and application of the high-dielectric-constant polyurethane, and belongs to the technical field of photoelectric materials. Zwitterionic pairs are introduced into a polyurethane chain segment through a chain extension means, positive and negative ions are ammonium positive ions / phosphate anions and / or phosphonium positive ions / sulfonate anions respectively, and the zwitterionic pairs are located on side chains. By introducing zwitterionic pairs, the dielectric constant of polyurethane can be remarkably improved, and by increasing the dielectric constant, the capacitance of the dielectric layer is increased under the conditions that the thickness of the dielectric layer is not reduced and the film performance of the dielectric layer is prevented from being damaged due to the fact that pinholes penetrate through the dielectric layer. The zwitter-ion pair is introduced to the side chain of the polyurethane, so that the dielectric property of the polyurethane is improved, and the dielectric constant is prevented from being reduced under a high-frequency alternating electric field; and when the polyurethane dielectric medium is applied to the organic field effect transistor as an insulating layer, the threshold voltage can be obviously reduced, and the original charge transfer performance can be maintained at the same time.

A proton exchange polymer comprises a polynorbornene copolymer with hydrophobic and hydrophilic blocks that can be phosphonated to produce phosphonic acid functional groups for proton exchange. Also, the polymer may be crosslinked to form quaternary ammonium groups on the side chains. The polynorbornene copolymer may be acid doped to ionically bond phosphonic acids to the quaternary ammonium groups that may for ion pairs for proton exchange. The proton exchange polymer has high temperature stability with the phosphonic acid functional group and can be mechanically durable with cross linking. Proton exchange membranes may utilize the proton exchange membrane in fuel cell and electrolyzer applications.

The application provides a method for detecting PFAS based on a three-dimensional Ag / NiFe-LDHs surface enhanced Raman scattering substrate and ion pair extraction, and belongs to the technical field of PFAS detection, and comprises the following steps: first, a three-dimensional Ag / NiFe-LDHs SERS substrate is prepared; then, ion pair extraction-dissociation treatment is performed on a water sample to be measured to obtain a detection solution; finally, the substrate is immersed in the detection solution for adsorption, a spectrum is collected by using a Raman spectrometer, and semi-quantitative detection of PFAS in the water sample is realized according to the linear relationship between the characteristic peak intensity and the logarithm of the molar concentration of PFAS. The application realizes the synergistic application of the three-dimensional Ag / NiFe-LDHs SERS substrate and the ion pair extraction technology and the indirect detection of PFAS, improves the detection difficulty of weak PFAS Raman signals and difficult enrichment, improves the detection sensitivity and adaptability of PFAS in the water sample, and lays an application foundation for rapid monitoring of PFAS pollution in environmental water.

The present application relates to the technical field of cosmetic biotechnology and nano-carrier drug delivery, and provides PDRN-putrescine co-delivery nano-liposome as well as a preparation method and application thereof.The PDRN-putrescine co-delivery nano-liposome provided by the present application comprises the following components in mass fraction: 0.1-3% of polydeoxyribonucleotide; 0.1-3% of putrescine; 2-8% of phospholipid emulsifier; 0-15% of polyhydric alcohol cosolvent; and the balance is a buffer solution; and the buffer solution has a pH value of 6-7.5.The present application realizes stable co-encapsulation of PDRN and putrescine by constructing a specific buffer system to regulate the pH value, using the amphiphilic property of the phospholipid bilayer and the in-situ ion pair technology, solves the compatibility problem of PDRN and putrescine, significantly improves the transdermal absorption rate of PDRN through transmembrane delivery of the nano-carrier, and realizes the synergistic repair and anti-aging effect of PDRN and putrescine at the cellular level.

The invention relates to the field of liquid chromatography and mass spectrometry methods, and provides a method and device for determining an MRM ion pair, electronic equipment and a storage medium. The method for determining the MRM ion pair comprises the following steps: inputting known information of a mixture into a prediction model to obtain predicted parent ions and predicted fragment ions of each substance in the mixture output by the prediction model, and obtaining a measurement instrument to perform single sampling and measurement on the mixture, obtaining a plurality of chromatographic peaks and actually measured parent ions and actually measured fragment ions corresponding to each chromatographic peak; matching the predicted parent ions with the actually measured parent ions, and matching the predicted fragment ions with the actually measured fragment ions; a target substance and an MRM ion pair corresponding to the target substance are determined, the target substance is a substance successfully matched with one of the chromatographic peaks, and the MRM ion pair comprises actually measured parent ions and actually measured fragment ions. Therefore, the MRM ion pairs of various substances in the mixture can be determined through single measurement on the mixture, and the measurement efficiency is improved.

The present invention provides a method for manufacturing a membrane electrode assembly (MEA) having a shortened initial activation time, the method involving preparing an assembly having a positive electrode layer and a negative electrode layer on opposite sides of an electrolyte membrane and applying specific pressure and temperature conditions. The electrolyte membrane includes a hydrocarbyl ionomer having an ion pair including a cation and an activator anion. The positive electrode layer and the negative electrode layer each contain an ionomer having a fluorine group derived from an activator. The monomer battery cell produced by the process can reach 95% of the maximum current density of the monomer battery cell within about 10 hours under specific conditions. The membrane electrode assembly itself is characterized in that the hydrocarbyl ionomer and the fluoro-based ionomer, activator or phosphoric acid are present throughout the membrane electrode assembly, achieving the same rapid activation time.

The invention relates to the technical field of high polymer materials, and discloses a temperature latent curing agent and a preparation method thereof.The curing agent is prepared from a polyamine compound and a polythiol compound through a proton transfer reaction at the temperature of 15-30 DEG C. In the reaction, the molar ratio of active amine hydrogen to thiol groups is 1: (0.9-1.1), and a stable ion pair structure is formed. The invention also discloses a single-component epoxy curing system containing the curing agent, epoxy resin and a dielectric constant jump additive. The system is endowed with excellent storage stability by utilizing an ion pair structure; meanwhile, after heating, the compatibility of the dielectric constant jump additive and the epoxy resin is changed, and the dielectric constant of the system is triggered to rise, so that ion pair constraint is weakened, and the curing agent is dissociated and rapidly cured at a moderate temperature. According to the technology, the contradiction between latency and curing conditions is solved, and a cured product has good thermal and mechanical properties.

According to the preparation method, cerium hydroxide with positive charges and without charge treatment on the surface is subjected to ultrasonic oscillation, so that a polymer or monomer containing negative charges and cerium hydroxide particles form coordinate bonds, first layer coating on the surface is realized, and surface charges are reversed into negative charges. Coating for the second time, adding a polymer with weak positive charges, polymerizing ion pairs through charge attraction, realizing secondary charge reversal and changing into positive charges. The invention discloses a method for repeatedly coating the surface of a cerium hydroxide particle, the electrical property of the coated cerium hydroxide particle is not changed, and the defect, namely particle adhesion, generated by mechanical force in the polishing process can be greatly reduced, so that the yield of a product is improved.

The application relates to a thermal electrochemical cell based on supercapacitor-mediated decoupling of heat and ion transmission, which comprises a hot-side half cell and a cold-side half cell, the two half cells are respectively filled with redox electrolyte, provided with ion isolation structures, and arranged with electrodes and supercapacitors immersed in the electrolyte. The supercapacitor serves as an ion transmission mediation core to realize decoupling of ion mass transfer and heat conduction; with the aid of the half cell and supercapacitor structure, on the one hand, the heat diffusion from the hot end to the cold end is blocked, heat loss is reduced, the thermal-electric conversion efficiency and the battery output power are improved; on the other hand, the supercapacitor interface ion adsorption / desorption characteristics are relied on to construct a rapid ion transmission path, efficient charge transfer between the half cells is guaranteed, the concentration of the redox ion pair is stabilized, cross contamination is avoided, the reaction can be continuously carried out reversibly, and the cycle stability is improved; the application effectively solves the technical problems of low power density, slow response and poor cycle stability of the traditional thermal electrochemical cell.

The invention discloses a preparation method of a high-dispersity carbon nanotube suspension, which comprises the following steps: S1, carrying out free radical copolymerization reaction and quaternization reaction on three raw materials of dimethylamino acrylate, furyl olefin and butadiene to obtain a quaternary ammonium salt cationic polymer chain segment; s2, carrying out free radical copolymerization reaction on the three raw materials, and then carrying out Diels-Alder reaction to obtain a sulfonate anion polymer chain segment; s3, carrying out ion pairing on the anion-cation polymer chain segment to obtain an ion pair polymer; and S4, compounding the high-dispersity carbon nanotube suspension liquid with a carbon nanotube, organic thixotropic wax and a polar organic solvent to obtain the high-dispersity carbon nanotube suspension liquid. According to the preparation method disclosed by the invention, high-concentration uniform dispersion of the carbon nanotubes is realized, the storage stability and thixotropic adjustability are also remarkably improved, the carbon nanotubes almost have no sedimentation after standing and can be quickly re-dispersed, and the strict requirements of rubber composite materials and the like on long-term stability and machinability can be met.

This application discloses a method to solubilize poorly soluble drugs in a liquid crystal vehicle for long-acting injectables. Poorly soluble acidic drugs-hydrophobic basic compounds ion pairs are incorporated into liquid crystal vehicles to solubilize and slowly release the drug after parenteral administration. Ion pairs such as Meloxicam-Dodecylamine, Sulfadiazine-Dodecylamine, Methotrexate-Dodecylamine, Levothyroxine-Dodecylamine, Meloxicam-Tridodecylamine, and Meloxicam-Bupivacaine are incorporated into liquid crystal vehicles to solubilize and control release the drugs.

A method for performing simultaneous entanglement gate operations in a trapped ion quantum computer includes: selecting a gate duration value and a detuning frequency of a pulse to be applied individually to a plurality of participating ions in a chain of trapped ions to simultaneously entangle a plurality of ion pairs in the plurality of participating ions through one or more predetermined values ​​of entanglement interactions; determining the amplitude of the pulse based on the selected gate duration value, the selected detuning frequency, and the frequency of the motion mode of the chain of trapped ions; generating the pulse with the determined amplitude; and applying the generated pulse to the plurality of participating ions at the selected gate duration value. Each trapped ion in the chain has two frequency-separated states defining a quantum bit, and the motion modes of the chain of trapped ions each have a different frequency.