99 results about "Ion pairing" patented technology

The present disclosure provides systems and methods for separating and characterizing oligonucleotides. Fixed dose combinations of small interfering RNAs can be subjected to denaturing ion pairing reverse phase liquid chromatography using optimal conditions to separate single RNA strands for purity analysis.

The invention provides a method for detecting PFAS based on a three-dimensional Ag / NiFe-LDHs surface enhanced Raman scattering substrate and ion pair extraction, and belongs to the technical field of PFAS detection.The method comprises the steps that firstly, the three-dimensional Ag / NiFe-LDHs SERS substrate is prepared, then ion pair extraction-dissociation treatment is conducted on a water sample to be detected, a detection solution is obtained, finally, the substrate is immersed in the detection solution for adsorption, and finally the detection solution is obtained. A spectrum is collected through a Raman spectrometer, and semi-quantitative detection of PFAS in a water sample is achieved according to the linear relation between the characteristic peak intensity and the PFAS molar concentration logarithm. According to the method, collaborative application of the three-dimensional Ag / NiFe-LDHs SERS substrate and an ion pair extraction technology and indirect detection of PFAS are realized, the detection difficulty that PFAS Raman signals are weak and are difficult to enrich is improved, the detection sensitivity and adaptability of PFAS in a water sample are improved, and an application foundation is laid for rapid monitoring of PFAS pollution of an environmental water body.

The invention discloses an ion-electron mixed conductor material and a preparation method and application thereof. The ion-electron mixed conductor material is prepared by doping a heterovalent transition metal element ion pair in a solid electrolyte. The different-valence transition metal element ion pairs comprise same transition metal elements with different valence states or different transition metal elements with different valence states; the solid electrolyte is halide solid electrolyte. Wherein the solid electrolyte structure provides a lithium ion transmission channel, and the transition metal element is rapidly oxidized and reduced to provide an electron transmission channel. The ion-electron mixed conductor is applied to a composite positive electrode of a solid-state battery, can simultaneously transmit lithium ions and electrons, shortens the transmission paths of the lithium ions and the electrons, remarkably improves the content of positive electrode active substances, improves the cycling stability of the solid-state battery, and has a relatively good application prospect in the solid-state battery.

The invention discloses a chiral alpha-amino acid with a C3 symmetric structure and a preparation method and application thereof, the chiral alpha-amino acid with the C3 symmetric structure provided by the invention is used as an ion pair catalyst, and the structure of the chiral alpha-amino acid with the C3 symmetric structure is more stable than that of other ion pair catalysts due to the C3 symmetric structure; and meanwhile, the chiral phosphamide compound is successfully constructed with relatively high yield (70-80%) and enantioselectivity (80-95%), so that the chiral phosphamide compound has excellent catalytic performance, and the problem that the chiral phosphamide compound is difficult to construct by a traditional ion pair catalyst is solved.

The present invention belongs to the field of medicinal chemistry and specifically discloses a light-responsive ion pair composition and its anti-cancer application. The ion pair composition includes a cyclometallic gold (III) complex and a photosensitizer, wherein the photosensitizer includes eosin (EY) or rose bengal (RB), and the structural formula of the cyclometallic gold (III) complex is shown in formula (1). The composition modifies the structure of the known cyclometallic gold (III) complex skeleton by adding hydroxyl groups, morpholine rings and deuteration, thereby improving its water solubility, charge properties, stability and other aspects. It can be efficiently activated by green light or even red light and has anti-cancer applications. The present invention achieves efficient activation of the cyclometallic gold (III) complex by combining the cyclometallic gold (III) complex with eosin (EY) or rose bengal (RB), and can extend the excitation wavelength to the red light range; and based on the ion pair properties and the characteristics of the tumor microenvironment, tumor-specific treatment can be achieved more accurately on the basis of light irradiation.

The invention relates to the technical field of electrochemical energy storage materials, and discloses a high-ionic-conductivity eutectic gel electrolyte and a preparation method thereof. The preparation method comprises the following steps: constructing a functional element precursor of sodium lignin sulfonate and histidine hydrochloride; inducing the sodium lignin sulfonate conformation to unfold and form an ion pair cluster in an acrylic monomer through hot shear stirring; the preparation method comprises the following steps: preparing a precursor, preparing a polyvinyl alcohol skeleton solution, mixing the polyvinyl alcohol skeleton solution with the precursor, introducing layered graphite, carrying out water bath heating, stirring and dispersing, and carrying out in-situ polymerization to form a gel electrolyte with a dual-network interpenetrating structure. And the dependence of ion transmission on free water is reduced, so that the gel electrolyte has high mechanical strength, excellent ionic conductivity and interface stability are realized, and zinc dendrite growth and side reaction are inhibited.

The invention firstly provides a phosphoric acid stable type high-temperature proton exchange membrane with amphiphilic polybenzimidazole and azide type ionic liquid, the ionic liquid in the composite membrane accounts for 30% by mass, and the prepared OHPBI-PIL-Px membrane exchanges anions into H2PO4 <-> through acid-base doping reaction, so that ion pairs are formed, and the proton exchange membrane has the advantages of high-temperature proton exchange, high-temperature proton exchange, high-temperature proton exchange and the like. The composite membrane constructs a proton transfer channel in a system, promotes proton transfer and transfer, provides alkaline quaternary ammonium sites, has strong acid-base interaction with PA, and can effectively reduce PA leakage. The long-term performance of the high-temperature proton exchange membrane can be enhanced. The invention further provides a preparation method of the stable high-temperature proton exchange membrane with the amphiphilic polybenzimidazole and azide ionic liquid phosphoric acid. The OHPBI-PIL-Px membrane is formed by crosslinking through an in-situ free radical polymerization method. The formed high-temperature proton exchange membrane is excellent in electrochemical performance and controllable in cost, has a production prospect and can be applied to the field of high-temperature proton exchange membrane fuel cells.

The invention discloses a method for improving ion pair reversed-phase liquid chromatography separation by using inert gas atmosphere protection and a chromatographic instrument mobile phase management system, and aims to prevent oxidation denaturation of an ion pair reagent in a mobile phase by using inert gas and prolong the service life of the mobile phase so as to improve the stability and reproducibility of the method. The method comprises the following steps: carrying out headspace replacement on a container filled with a mobile phase by using inert gas, pre-filling the inert gas protection box by using the inert gas, placing the container filled with the mobile phase in the inert gas protection box, carrying out sealed storage, and carrying out small-amount timed supplement on the inert gas protection box by using the inert gas. The method disclosed by the invention can be applied to reversed-phase liquid chromatography separation of a mobile phase added with an ion pair reagent and qualitative and quantitative analysis of combination of the reversed-phase liquid chromatography separation and an optical detector or a mass spectrum; after the method provided by the invention is used, the reproducibility and the stability of each analysis result are remarkably improved.

Disclosed is an electrolyte comprising: a first salt, wherein the first salt is an active material salt; a second salt; and a solvent, wherein the first salt and the second salt are dissolved in the solvent, such that the dissolved first salt has a solvation structure; wherein a solubility of the first salt in the solvent is greater than about 2 M; wherein the second salt is different from the first salt and has a solubility in the solvent lower than about 2 M; wherein the second salt behaves as a diluent and is at least partially incorporated into the solvation structure; such that the solvation structure is substantially dominated by a plurality of solvent-separated pairs, contact-ion pairs, aggregates or a combination thereof. Also disclosed are electrochemical cells comprising such electrolytes. Also disclosed are methods of making the disclosed herein electrolytes and electrochemical cells.

The invention discloses a method for enhancing up-conversion avalanche nonlinearity based on metal ion regulation sublattice, which comprises the following steps: S1, selecting crystal matrix doped up-conversion avalanche activator ions as activation ions for realizing up-conversion avalanche nonlinearity; s2, co-doping one or more non-luminous metal ions on the basis of the activator ion-doped crystal matrix obtained in the S1 to replace matrix cations in the crystal matrix so as to complete sublattice shrinkage; s3, sublattice shrinkage in S2 acts on activating agent ions, so that the average physical distance of activating agent ion pairs in the system is shortened, and the efficiency of a specific cross relaxation process beneficial to upconversion avalanche nonlinearity is improved by shortening the ion spacing. Compared with the prior art, the method has the advantages that the population rate of a key intermediate energy level is enhanced, so that avalanche nonlinearity of up-conversion emission is greatly improved in a measurable manner, and the limitation of traditional up-conversion energy transfer efficiency and avalanche nonlinearity regulation is broken through.

The present application relates to the technical field of pharmaceutical analysis, and specifically discloses a method for detecting the purity of doxycycline for injection. The present application mainly solves the problems caused by ion pair reagent and high-salt buffer in the existing chromatographic method, such as serious pollution of the system pipeline and the chromatographic column, difficulty in connecting with mass spectrometry for impurity structure identification, and insufficient separation degree of key polar impurities such as 4-epi doxycycline. The present application purifies the sample by physical dilution and filtration, and prepares uniform aerosol by ultrasonic atomization. The ion mobility spectrometry technology is adopted to realize the efficient separation of gas-phase ions under a weak electric field according to the difference in ion collision cross section (CCS) value, and the epimer which is difficult to distinguish by traditional methods can be excellently separated. The multi-modal sensor is used to synchronously collect ultraviolet, fluorescent and terahertz multi-dimensional optical signals. Finally, based on the intrinsic physical parameter database, the intelligent analysis is carried out by using the machine learning algorithm, and the qualitative and quantitative results are automatically output.

The application provides a method for detecting PFAS based on a three-dimensional Ag / NiFe-LDHs surface enhanced Raman scattering substrate and ion pair extraction, and belongs to the technical field of PFAS detection, and comprises the following steps: first, a three-dimensional Ag / NiFe-LDHs SERS substrate is prepared; then, ion pair extraction-dissociation treatment is performed on a water sample to be measured to obtain a detection solution; finally, the substrate is immersed in the detection solution for adsorption, a spectrum is collected by using a Raman spectrometer, and semi-quantitative detection of PFAS in the water sample is realized according to the linear relationship between the characteristic peak intensity and the logarithm of the molar concentration of PFAS. The application realizes the synergistic application of the three-dimensional Ag / NiFe-LDHs SERS substrate and the ion pair extraction technology and the indirect detection of PFAS, improves the detection difficulty of weak PFAS Raman signals and difficult enrichment, improves the detection sensitivity and adaptability of PFAS in the water sample, and lays an application foundation for rapid monitoring of PFAS pollution in environmental water.

The present application relates to the technical field of cosmetic biotechnology and nano-carrier drug delivery, and provides PDRN-putrescine co-delivery nano-liposome as well as a preparation method and application thereof.The PDRN-putrescine co-delivery nano-liposome provided by the present application comprises the following components in mass fraction: 0.1-3% of polydeoxyribonucleotide; 0.1-3% of putrescine; 2-8% of phospholipid emulsifier; 0-15% of polyhydric alcohol cosolvent; and the balance is a buffer solution; and the buffer solution has a pH value of 6-7.5.The present application realizes stable co-encapsulation of PDRN and putrescine by constructing a specific buffer system to regulate the pH value, using the amphiphilic property of the phospholipid bilayer and the in-situ ion pair technology, solves the compatibility problem of PDRN and putrescine, significantly improves the transdermal absorption rate of PDRN through transmembrane delivery of the nano-carrier, and realizes the synergistic repair and anti-aging effect of PDRN and putrescine at the cellular level.

The invention relates to the field of liquid chromatography and mass spectrometry methods, and provides a method and device for determining an MRM ion pair, electronic equipment and a storage medium. The method for determining the MRM ion pair comprises the following steps: inputting known information of a mixture into a prediction model to obtain predicted parent ions and predicted fragment ions of each substance in the mixture output by the prediction model, and obtaining a measurement instrument to perform single sampling and measurement on the mixture, obtaining a plurality of chromatographic peaks and actually measured parent ions and actually measured fragment ions corresponding to each chromatographic peak; matching the predicted parent ions with the actually measured parent ions, and matching the predicted fragment ions with the actually measured fragment ions; a target substance and an MRM ion pair corresponding to the target substance are determined, the target substance is a substance successfully matched with one of the chromatographic peaks, and the MRM ion pair comprises actually measured parent ions and actually measured fragment ions. Therefore, the MRM ion pairs of various substances in the mixture can be determined through single measurement on the mixture, and the measurement efficiency is improved.

The present invention provides a method for manufacturing a membrane electrode assembly (MEA) having a shortened initial activation time, the method involving preparing an assembly having a positive electrode layer and a negative electrode layer on opposite sides of an electrolyte membrane and applying specific pressure and temperature conditions. The electrolyte membrane includes a hydrocarbyl ionomer having an ion pair including a cation and an activator anion. The positive electrode layer and the negative electrode layer each contain an ionomer having a fluorine group derived from an activator. The monomer battery cell produced by the process can reach 95% of the maximum current density of the monomer battery cell within about 10 hours under specific conditions. The membrane electrode assembly itself is characterized in that the hydrocarbyl ionomer and the fluoro-based ionomer, activator or phosphoric acid are present throughout the membrane electrode assembly, achieving the same rapid activation time.

The invention relates to the technical field of high polymer materials, and discloses a temperature latent curing agent and a preparation method thereof.The curing agent is prepared from a polyamine compound and a polythiol compound through a proton transfer reaction at the temperature of 15-30 DEG C. In the reaction, the molar ratio of active amine hydrogen to thiol groups is 1: (0.9-1.1), and a stable ion pair structure is formed. The invention also discloses a single-component epoxy curing system containing the curing agent, epoxy resin and a dielectric constant jump additive. The system is endowed with excellent storage stability by utilizing an ion pair structure; meanwhile, after heating, the compatibility of the dielectric constant jump additive and the epoxy resin is changed, and the dielectric constant of the system is triggered to rise, so that ion pair constraint is weakened, and the curing agent is dissociated and rapidly cured at a moderate temperature. According to the technology, the contradiction between latency and curing conditions is solved, and a cured product has good thermal and mechanical properties.

According to the preparation method, cerium hydroxide with positive charges and without charge treatment on the surface is subjected to ultrasonic oscillation, so that a polymer or monomer containing negative charges and cerium hydroxide particles form coordinate bonds, first layer coating on the surface is realized, and surface charges are reversed into negative charges. Coating for the second time, adding a polymer with weak positive charges, polymerizing ion pairs through charge attraction, realizing secondary charge reversal and changing into positive charges. The invention discloses a method for repeatedly coating the surface of a cerium hydroxide particle, the electrical property of the coated cerium hydroxide particle is not changed, and the defect, namely particle adhesion, generated by mechanical force in the polishing process can be greatly reduced, so that the yield of a product is improved.

The application relates to a thermal electrochemical cell based on supercapacitor-mediated decoupling of heat and ion transmission, which comprises a hot-side half cell and a cold-side half cell, the two half cells are respectively filled with redox electrolyte, provided with ion isolation structures, and arranged with electrodes and supercapacitors immersed in the electrolyte. The supercapacitor serves as an ion transmission mediation core to realize decoupling of ion mass transfer and heat conduction; with the aid of the half cell and supercapacitor structure, on the one hand, the heat diffusion from the hot end to the cold end is blocked, heat loss is reduced, the thermal-electric conversion efficiency and the battery output power are improved; on the other hand, the supercapacitor interface ion adsorption / desorption characteristics are relied on to construct a rapid ion transmission path, efficient charge transfer between the half cells is guaranteed, the concentration of the redox ion pair is stabilized, cross contamination is avoided, the reaction can be continuously carried out reversibly, and the cycle stability is improved; the application effectively solves the technical problems of low power density, slow response and poor cycle stability of the traditional thermal electrochemical cell.

The invention discloses a preparation method of a high-dispersity carbon nanotube suspension, which comprises the following steps: S1, carrying out free radical copolymerization reaction and quaternization reaction on three raw materials of dimethylamino acrylate, furyl olefin and butadiene to obtain a quaternary ammonium salt cationic polymer chain segment; s2, carrying out free radical copolymerization reaction on the three raw materials, and then carrying out Diels-Alder reaction to obtain a sulfonate anion polymer chain segment; s3, carrying out ion pairing on the anion-cation polymer chain segment to obtain an ion pair polymer; and S4, compounding the high-dispersity carbon nanotube suspension liquid with a carbon nanotube, organic thixotropic wax and a polar organic solvent to obtain the high-dispersity carbon nanotube suspension liquid. According to the preparation method disclosed by the invention, high-concentration uniform dispersion of the carbon nanotubes is realized, the storage stability and thixotropic adjustability are also remarkably improved, the carbon nanotubes almost have no sedimentation after standing and can be quickly re-dispersed, and the strict requirements of rubber composite materials and the like on long-term stability and machinability can be met.

This application discloses a method to solubilize poorly soluble drugs in a liquid crystal vehicle for long-acting injectables. Poorly soluble acidic drugs-hydrophobic basic compounds ion pairs are incorporated into liquid crystal vehicles to solubilize and slowly release the drug after parenteral administration. Ion pairs such as Meloxicam-Dodecylamine, Sulfadiazine-Dodecylamine, Methotrexate-Dodecylamine, Levothyroxine-Dodecylamine, Meloxicam-Tridodecylamine, and Meloxicam-Bupivacaine are incorporated into liquid crystal vehicles to solubilize and control release the drugs.

The application belongs to the field of energy storage ceramic materials, and specifically provides a copper-barium titanate-based energy storage ceramic material with high energy storage density and high efficiency and a preparation method thereof. 0.97 Cu 0.03 )O3‑xNa(Nb 1‑y Ta y )O3(0.02≤x≤0.2, 0.05≤y≤0.2). Different valence ions are introduced into A sites and B sites of Ba(Ti 0.97 Cu 0.03 )O3 ceramics, thereby producing charge mismatch, Na + is introduced into the A sites to form Na + -Na + ion pairs and improve local polarization intensity, thereby improving energy storage density, Nb 5+ and Ta 5+ ions with different valences are introduced into the B sites to cause distortion of oxygen octahedrons and increase of displacement of B-site cations, thereby producing lattice distortion and improving energy storage efficiency and breakdown strength. The method is simple in steps, low in equipment requirement, and can be mass-produced.

The application belongs to the field of new adjuvants and new dosage forms of pharmaceutical preparations, and particularly relates to a type I and type II immunogenic cell death inducer ion pairing engineered nanoassemblies as well as construction and application thereof. The nanoassemblies are composed of type I ICD inducers, type II ICD inducers, hydrophobic auxiliary counterions and amphiphilic lipid ion pairing. The type I ICD inducer is selected from mitoxantrone, doxorubicin, oxaliplatin or cyclophosphamide; the type II ICD inducer is selected from hypericin; and the hydrophobic auxiliary counterion is selected from cholesteryl sodium sulfate, cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid, glycolcholic acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, deoxycholic acid lysine derivative, oleanolic acid and ursolic acid. The type I and type II ICD inducers are combined in the application, and have a synergistic tumor treatment effect.

The application provides a light conversion agent, a preparation method and application thereof, and a light conversion film, and belongs to the technical field of chemical synthesis. The light conversion agent is an organic salt ion-rare earth Eu (III) anion type, is an ion pair type light conversion agent, has absorption of organic and inorganic complexes, has stronger ultraviolet absorption capacity, and is synthesized by introducing an electron-donating group N,N-dimethyl into a para position of a pyridine nitrogen and introducing a bromohexyl group to form a corresponding electron-withdrawing pyridine group to synthesize a pyridine salt, and is synthesized by taking 2-thiophene formyl trifluoroacetylacetone as a ligand to synthesize a rare earth anion complex Eu (HTTA) 4 ‑ By ion exchange, bromine ions in the pyridine salt are replaced by the complex anions, and by electrostatic interaction between the pyridine cation and the anion complex, sensitization of rare earth luminescence is realized, and the ultraviolet absorption capacity is improved. Moreover, the light conversion agent has a long alkyl flexible chain, can be better blended with LLDPE, and enhances the stability and dispersibility of the light conversion agent in resin.

This invention relates to the field of anthocyanin detection technology, specifically to a database of six anthocyanin ion pairs and its establishment method, and a method for identifying six anthocyanins in blueberries based on this database. Under ultra-high performance liquid chromatography / high resolution tandem mass spectrometry (UHPLC / HDMS) conditions, this invention collects the precise mass-to-charge ratios of the precursor ions of the six anthocyanins and the precise mass-to-charge ratios of all their corresponding product ions; using MS-FINDER software, it derives the possible chemical structures of the product ions; finally, it derives the determined chemical structures of the product ions according to DFT density functional theory, ultimately establishing a database of six anthocyanins ion pairs. The identification method of this invention is simple, mainly using ring-fracture ion pairs for judgment. Each of the six anthocyanins has different complementary ion pairs, which can be used for qualitative analysis. The ion pair database of this invention can serve as a basis for non-targeted detection, optimizing the detection steps, improving detection efficiency, and exhibiting high accuracy and sensitivity.

The present application relates to the technical field of health product ingredient detection, in particular to a detection method of a new type of sildenafil compound in health food, comprising the following steps: qualitative and quantitative detection by HPLC-MS / MS; the chromatographic conditions include: a chromatographic column, a C18 column; a column temperature, 40 DEG C; a mobile phase A, 0.1% formic acid aqueous solution; a mobile phase B, acetonitrile; a flow rate, 0.5 mL / min; a gradient elution program, 0~2.0 min, 10%B~95%B; 2.0~5.0 min, 95%B; 5.0~5.1 min, 95%B~5%B; 5.1~8.0 min, 5%B; a sample injection amount, 5 µL; the mass spectrometry conditions include: an ionization mode, an electrospray ionization source, a positive ion mode; an electrospray voltage, 5500 V; an ion source temperature, 550 DEG C; an atomization gas pressure, 345 kPa; an auxiliary gas pressure, 414 kPa; a curtain gas pressure, 276 kPa; a declustering voltage, 100 V; a collision energy, 45 V; a quantitative ion pair, 449 / 243; a qualitative ion pair, 449 / 259; the residence time of each ion pair, 250 ms; the new type of sildenafil compound contains a methyl piperazine group. The detection method of the present application is simple in operation, short in time consumption, high in sensitivity and good in stability.

1. The name of the design product: remote plasma source emitter. 2. The use of the design product: used for dissociating nitrogen trifluoride gas into fluoride ion pairs for chamber cleaning, surface treatment, material modification, thin film deposition and other processes in a vacuum environment. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: Design 1 perspective view. 5. Design 1 is designated as the basic design.

In the present invention, positively charged cerium hydroxide particles without undergoing surface charge treatment are subjected to ultrasonic agitation, so that a negatively charged polymer or monomer and the cerium hydroxide particles form a coordination bond, thereby forming a first surface coating layer and reversing the surface charge into a negative charge; and in a second coating step, a weakly positively charged polymer is added, so that by means of charge attraction, a polymeric ion pair is formed, thereby achieving a second charge reversal to a positive charge. Disclosed in the present invention is a method for multiple surface coatings of cerium hydroxide particles. The coated cerium hydroxide particles do not change the intrinsic electrical properties thereof, and can greatly reduce defects caused by mechanical forces during polishing, such as particle adhesion, thereby improving the product yield.

The application discloses a magnetic solid phase extraction method and application thereof, and belongs to the field of chemical analysis. The magnetic solid phase extraction method provided by the application uses ion pair reagents to assist magnetic solid phase extraction. The magnetic solid phase extraction method provided by the application can significantly improve the saturated adsorption capacity of polar compounds, and has obvious adsorption selectivity, and has the advantages of high sample pretreatment efficiency, rapid adsorption, simple separation operation, green environmental protection, and renewable use of magnetic adsorption materials, and has a wide application in detection of polar compounds.

The present application relates to the construction method of the ophthalmic protein drug sustained-release preparation, the ophthalmic protein drug is contacted with the weakly interacting excipient of pharmaceutically acceptable, and the protein pre-holding complex is formed;The first hydration excipient and the second hydration excipient are sequentially added to the protein pre-holding complex, and the layered hydrated protein complex is formed;The layered hydrated protein complex is dispersed in the first continuous phase of the ionizable group-containing pharmaceutically high polymer, and the ion pairing release blocking layer is formed in the periphery by adjusting the ion environment, and the intermediate is obtained;The intermediate is dispersed in the second continuous phase of the ophthalmic pharmaceutically acceptable, and the ophthalmic protein drug sustained-release preparation is prepared.The ophthalmic protein drug is pre-held with the weakly interacting excipient, the differentiated occupation area and the layered hydration structure are constructed, the protein stability is improved;Through the stage ion regulation, the pharmaceutically high polymer forms the non-closed ion pairing release blocking layer, the protein release fine control is realized, the drug efficacy is prolonged and the curative effect is improved.

The invention discloses a method and system for optimizing two-dimensional argon plasma uniformity by introducing a high-energy particle source, and the method comprises the steps: S1, filling a plasma reaction chamber with background gas, and simulating the distribution of neutral particles; s2, initializing the speed and the position of charged particles in the gas in the chamber, enabling the charged particles to be uniformly distributed in the chamber, and determining the intensity, the time sequence, the incident direction and the incident position of high-energy particles emitted by an external particle source; s3, calculation of charged particle density, potential and electric field; s4, calculating the force acting on the charged particles; s5, moving the charged particles; s6, checking and executing collision; and S7, repeating the steps S3 to S6, adjusting the high-energy particle injection time sequence until a steady state is reached, and obtaining the data distribution of the charged particles. Through controllable interaction between an external particle source and plasma or background gas, seed electrons-ions are actively generated in a specific space area or energy distribution is changed, and inherent space non-uniformity of the plasma is compensated.