58 results about "Ion pairing" patented technology

The invention relates to the technical field of electrochemical energy storage materials, and discloses a high-ionic-conductivity eutectic gel electrolyte and a preparation method thereof. The preparation method comprises the following steps: constructing a functional element precursor of sodium lignin sulfonate and histidine hydrochloride; inducing the sodium lignin sulfonate conformation to unfold and form an ion pair cluster in an acrylic monomer through hot shear stirring; the preparation method comprises the following steps: preparing a precursor, preparing a polyvinyl alcohol skeleton solution, mixing the polyvinyl alcohol skeleton solution with the precursor, introducing layered graphite, carrying out water bath heating, stirring and dispersing, and carrying out in-situ polymerization to form a gel electrolyte with a dual-network interpenetrating structure. And the dependence of ion transmission on free water is reduced, so that the gel electrolyte has high mechanical strength, excellent ionic conductivity and interface stability are realized, and zinc dendrite growth and side reaction are inhibited.

The invention firstly provides a phosphoric acid stable type high-temperature proton exchange membrane with amphiphilic polybenzimidazole and azide type ionic liquid, the ionic liquid in the composite membrane accounts for 30% by mass, and the prepared OHPBI-PIL-Px membrane exchanges anions into H2PO4 <-> through acid-base doping reaction, so that ion pairs are formed, and the proton exchange membrane has the advantages of high-temperature proton exchange, high-temperature proton exchange, high-temperature proton exchange and the like. The composite membrane constructs a proton transfer channel in a system, promotes proton transfer and transfer, provides alkaline quaternary ammonium sites, has strong acid-base interaction with PA, and can effectively reduce PA leakage. The long-term performance of the high-temperature proton exchange membrane can be enhanced. The invention further provides a preparation method of the stable high-temperature proton exchange membrane with the amphiphilic polybenzimidazole and azide ionic liquid phosphoric acid. The OHPBI-PIL-Px membrane is formed by crosslinking through an in-situ free radical polymerization method. The formed high-temperature proton exchange membrane is excellent in electrochemical performance and controllable in cost, has a production prospect and can be applied to the field of high-temperature proton exchange membrane fuel cells.

Disclosed is an electrolyte comprising: a first salt, wherein the first salt is an active material salt; a second salt; and a solvent, wherein the first salt and the second salt are dissolved in the solvent, such that the dissolved first salt has a solvation structure; wherein a solubility of the first salt in the solvent is greater than about 2 M; wherein the second salt is different from the first salt and has a solubility in the solvent lower than about 2 M; wherein the second salt behaves as a diluent and is at least partially incorporated into the solvation structure; such that the solvation structure is substantially dominated by a plurality of solvent-separated pairs, contact-ion pairs, aggregates or a combination thereof. Also disclosed are electrochemical cells comprising such electrolytes. Also disclosed are methods of making the disclosed herein electrolytes and electrochemical cells.

The invention discloses a method for enhancing up-conversion avalanche nonlinearity based on metal ion regulation sublattice, which comprises the following steps: S1, selecting crystal matrix doped up-conversion avalanche activator ions as activation ions for realizing up-conversion avalanche nonlinearity; s2, co-doping one or more non-luminous metal ions on the basis of the activator ion-doped crystal matrix obtained in the S1 to replace matrix cations in the crystal matrix so as to complete sublattice shrinkage; s3, sublattice shrinkage in S2 acts on activating agent ions, so that the average physical distance of activating agent ion pairs in the system is shortened, and the efficiency of a specific cross relaxation process beneficial to upconversion avalanche nonlinearity is improved by shortening the ion spacing. Compared with the prior art, the method has the advantages that the population rate of a key intermediate energy level is enhanced, so that avalanche nonlinearity of up-conversion emission is greatly improved in a measurable manner, and the limitation of traditional up-conversion energy transfer efficiency and avalanche nonlinearity regulation is broken through.

The present application relates to the technical field of pharmaceutical analysis, and specifically discloses a method for detecting the purity of doxycycline for injection. The present application mainly solves the problems caused by ion pair reagent and high-salt buffer in the existing chromatographic method, such as serious pollution of the system pipeline and the chromatographic column, difficulty in connecting with mass spectrometry for impurity structure identification, and insufficient separation degree of key polar impurities such as 4-epi doxycycline. The present application purifies the sample by physical dilution and filtration, and prepares uniform aerosol by ultrasonic atomization. The ion mobility spectrometry technology is adopted to realize the efficient separation of gas-phase ions under a weak electric field according to the difference in ion collision cross section (CCS) value, and the epimer which is difficult to distinguish by traditional methods can be excellently separated. The multi-modal sensor is used to synchronously collect ultraviolet, fluorescent and terahertz multi-dimensional optical signals. Finally, based on the intrinsic physical parameter database, the intelligent analysis is carried out by using the machine learning algorithm, and the qualitative and quantitative results are automatically output.

The application provides a method for detecting PFAS based on a three-dimensional Ag / NiFe-LDHs surface enhanced Raman scattering substrate and ion pair extraction, and belongs to the technical field of PFAS detection, and comprises the following steps: first, a three-dimensional Ag / NiFe-LDHs SERS substrate is prepared; then, ion pair extraction-dissociation treatment is performed on a water sample to be measured to obtain a detection solution; finally, the substrate is immersed in the detection solution for adsorption, a spectrum is collected by using a Raman spectrometer, and semi-quantitative detection of PFAS in the water sample is realized according to the linear relationship between the characteristic peak intensity and the logarithm of the molar concentration of PFAS. The application realizes the synergistic application of the three-dimensional Ag / NiFe-LDHs SERS substrate and the ion pair extraction technology and the indirect detection of PFAS, improves the detection difficulty of weak PFAS Raman signals and difficult enrichment, improves the detection sensitivity and adaptability of PFAS in the water sample, and lays an application foundation for rapid monitoring of PFAS pollution in environmental water.

The present application relates to the technical field of cosmetic biotechnology and nano-carrier drug delivery, and provides PDRN-putrescine co-delivery nano-liposome as well as a preparation method and application thereof.The PDRN-putrescine co-delivery nano-liposome provided by the present application comprises the following components in mass fraction: 0.1-3% of polydeoxyribonucleotide; 0.1-3% of putrescine; 2-8% of phospholipid emulsifier; 0-15% of polyhydric alcohol cosolvent; and the balance is a buffer solution; and the buffer solution has a pH value of 6-7.5.The present application realizes stable co-encapsulation of PDRN and putrescine by constructing a specific buffer system to regulate the pH value, using the amphiphilic property of the phospholipid bilayer and the in-situ ion pair technology, solves the compatibility problem of PDRN and putrescine, significantly improves the transdermal absorption rate of PDRN through transmembrane delivery of the nano-carrier, and realizes the synergistic repair and anti-aging effect of PDRN and putrescine at the cellular level.

The invention relates to the field of liquid chromatography and mass spectrometry methods, and provides a method and device for determining an MRM ion pair, electronic equipment and a storage medium. The method for determining the MRM ion pair comprises the following steps: inputting known information of a mixture into a prediction model to obtain predicted parent ions and predicted fragment ions of each substance in the mixture output by the prediction model, and obtaining a measurement instrument to perform single sampling and measurement on the mixture, obtaining a plurality of chromatographic peaks and actually measured parent ions and actually measured fragment ions corresponding to each chromatographic peak; matching the predicted parent ions with the actually measured parent ions, and matching the predicted fragment ions with the actually measured fragment ions; a target substance and an MRM ion pair corresponding to the target substance are determined, the target substance is a substance successfully matched with one of the chromatographic peaks, and the MRM ion pair comprises actually measured parent ions and actually measured fragment ions. Therefore, the MRM ion pairs of various substances in the mixture can be determined through single measurement on the mixture, and the measurement efficiency is improved.

The invention relates to the technical field of high polymer materials, and discloses a temperature latent curing agent and a preparation method thereof.The curing agent is prepared from a polyamine compound and a polythiol compound through a proton transfer reaction at the temperature of 15-30 DEG C. In the reaction, the molar ratio of active amine hydrogen to thiol groups is 1: (0.9-1.1), and a stable ion pair structure is formed. The invention also discloses a single-component epoxy curing system containing the curing agent, epoxy resin and a dielectric constant jump additive. The system is endowed with excellent storage stability by utilizing an ion pair structure; meanwhile, after heating, the compatibility of the dielectric constant jump additive and the epoxy resin is changed, and the dielectric constant of the system is triggered to rise, so that ion pair constraint is weakened, and the curing agent is dissociated and rapidly cured at a moderate temperature. According to the technology, the contradiction between latency and curing conditions is solved, and a cured product has good thermal and mechanical properties.

According to the preparation method, cerium hydroxide with positive charges and without charge treatment on the surface is subjected to ultrasonic oscillation, so that a polymer or monomer containing negative charges and cerium hydroxide particles form coordinate bonds, first layer coating on the surface is realized, and surface charges are reversed into negative charges. Coating for the second time, adding a polymer with weak positive charges, polymerizing ion pairs through charge attraction, realizing secondary charge reversal and changing into positive charges. The invention discloses a method for repeatedly coating the surface of a cerium hydroxide particle, the electrical property of the coated cerium hydroxide particle is not changed, and the defect, namely particle adhesion, generated by mechanical force in the polishing process can be greatly reduced, so that the yield of a product is improved.

This application discloses a method to solubilize poorly soluble drugs in a liquid crystal vehicle for long-acting injectables. Poorly soluble acidic drugs-hydrophobic basic compounds ion pairs are incorporated into liquid crystal vehicles to solubilize and slowly release the drug after parenteral administration. Ion pairs such as Meloxicam-Dodecylamine, Sulfadiazine-Dodecylamine, Methotrexate-Dodecylamine, Levothyroxine-Dodecylamine, Meloxicam-Tridodecylamine, and Meloxicam-Bupivacaine are incorporated into liquid crystal vehicles to solubilize and control release the drugs.

The application belongs to the field of new adjuvants and new dosage forms of pharmaceutical preparations, and particularly relates to a type I and type II immunogenic cell death inducer ion pairing engineered nanoassemblies as well as construction and application thereof. The nanoassemblies are composed of type I ICD inducers, type II ICD inducers, hydrophobic auxiliary counterions and amphiphilic lipid ion pairing. The type I ICD inducer is selected from mitoxantrone, doxorubicin, oxaliplatin or cyclophosphamide; the type II ICD inducer is selected from hypericin; and the hydrophobic auxiliary counterion is selected from cholesteryl sodium sulfate, cholic acid, deoxycholic acid, chenodeoxycholic acid, lithocholic acid, glycolcholic acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, deoxycholic acid lysine derivative, oleanolic acid and ursolic acid. The type I and type II ICD inducers are combined in the application, and have a synergistic tumor treatment effect.

This invention relates to the field of anthocyanin detection technology, specifically to a database of six anthocyanin ion pairs and its establishment method, and a method for identifying six anthocyanins in blueberries based on this database. Under ultra-high performance liquid chromatography / high resolution tandem mass spectrometry (UHPLC / HDMS) conditions, this invention collects the precise mass-to-charge ratios of the precursor ions of the six anthocyanins and the precise mass-to-charge ratios of all their corresponding product ions; using MS-FINDER software, it derives the possible chemical structures of the product ions; finally, it derives the determined chemical structures of the product ions according to DFT density functional theory, ultimately establishing a database of six anthocyanins ion pairs. The identification method of this invention is simple, mainly using ring-fracture ion pairs for judgment. Each of the six anthocyanins has different complementary ion pairs, which can be used for qualitative analysis. The ion pair database of this invention can serve as a basis for non-targeted detection, optimizing the detection steps, improving detection efficiency, and exhibiting high accuracy and sensitivity.

The present application relates to the technical field of health product ingredient detection, in particular to a detection method of a new type of sildenafil compound in health food, comprising the following steps: qualitative and quantitative detection by HPLC-MS / MS; the chromatographic conditions include: a chromatographic column, a C18 column; a column temperature, 40 DEG C; a mobile phase A, 0.1% formic acid aqueous solution; a mobile phase B, acetonitrile; a flow rate, 0.5 mL / min; a gradient elution program, 0~2.0 min, 10%B~95%B; 2.0~5.0 min, 95%B; 5.0~5.1 min, 95%B~5%B; 5.1~8.0 min, 5%B; a sample injection amount, 5 µL; the mass spectrometry conditions include: an ionization mode, an electrospray ionization source, a positive ion mode; an electrospray voltage, 5500 V; an ion source temperature, 550 DEG C; an atomization gas pressure, 345 kPa; an auxiliary gas pressure, 414 kPa; a curtain gas pressure, 276 kPa; a declustering voltage, 100 V; a collision energy, 45 V; a quantitative ion pair, 449 / 243; a qualitative ion pair, 449 / 259; the residence time of each ion pair, 250 ms; the new type of sildenafil compound contains a methyl piperazine group. The detection method of the present application is simple in operation, short in time consumption, high in sensitivity and good in stability.

In the present invention, positively charged cerium hydroxide particles without undergoing surface charge treatment are subjected to ultrasonic agitation, so that a negatively charged polymer or monomer and the cerium hydroxide particles form a coordination bond, thereby forming a first surface coating layer and reversing the surface charge into a negative charge; and in a second coating step, a weakly positively charged polymer is added, so that by means of charge attraction, a polymeric ion pair is formed, thereby achieving a second charge reversal to a positive charge. Disclosed in the present invention is a method for multiple surface coatings of cerium hydroxide particles. The coated cerium hydroxide particles do not change the intrinsic electrical properties thereof, and can greatly reduce defects caused by mechanical forces during polishing, such as particle adhesion, thereby improving the product yield.

The application discloses a magnetic solid phase extraction method and application thereof, and belongs to the field of chemical analysis. The magnetic solid phase extraction method provided by the application uses ion pair reagents to assist magnetic solid phase extraction. The magnetic solid phase extraction method provided by the application can significantly improve the saturated adsorption capacity of polar compounds, and has obvious adsorption selectivity, and has the advantages of high sample pretreatment efficiency, rapid adsorption, simple separation operation, green environmental protection, and renewable use of magnetic adsorption materials, and has a wide application in detection of polar compounds.

The present application relates to the construction method of the ophthalmic protein drug sustained-release preparation, the ophthalmic protein drug is contacted with the weakly interacting excipient of pharmaceutically acceptable, and the protein pre-holding complex is formed;The first hydration excipient and the second hydration excipient are sequentially added to the protein pre-holding complex, and the layered hydrated protein complex is formed;The layered hydrated protein complex is dispersed in the first continuous phase of the ionizable group-containing pharmaceutically high polymer, and the ion pairing release blocking layer is formed in the periphery by adjusting the ion environment, and the intermediate is obtained;The intermediate is dispersed in the second continuous phase of the ophthalmic pharmaceutically acceptable, and the ophthalmic protein drug sustained-release preparation is prepared.The ophthalmic protein drug is pre-held with the weakly interacting excipient, the differentiated occupation area and the layered hydration structure are constructed, the protein stability is improved;Through the stage ion regulation, the pharmaceutically high polymer forms the non-closed ion pairing release blocking layer, the protein release fine control is realized, the drug efficacy is prolonged and the curative effect is improved.

The invention discloses a method and system for optimizing two-dimensional argon plasma uniformity by introducing a high-energy particle source, and the method comprises the steps: S1, filling a plasma reaction chamber with background gas, and simulating the distribution of neutral particles; s2, initializing the speed and the position of charged particles in the gas in the chamber, enabling the charged particles to be uniformly distributed in the chamber, and determining the intensity, the time sequence, the incident direction and the incident position of high-energy particles emitted by an external particle source; s3, calculation of charged particle density, potential and electric field; s4, calculating the force acting on the charged particles; s5, moving the charged particles; s6, checking and executing collision; and S7, repeating the steps S3 to S6, adjusting the high-energy particle injection time sequence until a steady state is reached, and obtaining the data distribution of the charged particles. Through controllable interaction between an external particle source and plasma or background gas, seed electrons-ions are actively generated in a specific space area or energy distribution is changed, and inherent space non-uniformity of the plasma is compensated.

The application discloses a kind of MXene nanometer roll, composite material and its preparation method and use, wherein, the MXene nanometer roll is a kind of MXene material with one-dimensional hollow roll structure, by two-dimensional MXene material curling self-assembly is obtained, break the cognition of people to MXene material belongs to two-dimensional material.The application further provides the preparation method of MXene nanometer roll, steps include: two-dimensional MXene material or etching MAX phase material is obtained accordion appearance etching material, dispersed in liquid phase containing positive ion pair reagent, under the action of external force, obtain MXene nanometer roll, preparation method is simple and easy to operate.The MXene nanometer roll of the application and carbon nanotube all have one-dimensional nanostructure, can be used as alternative material to replace carbon nanotube;Since the application also has the characteristics of distinguishing carbon nanotube, more new field applications can be realized, such as as slow-release material etc.

The invention belongs to a mass spectrometry technology, and particularly provides a detection method of a triple quadrupole mass spectrometer, which comprises the following steps: A1, setting basic parameters of the mass spectrometer, and establishing compound acquisition initial parameters; the basic parameters comprise detection window time T11 and target detection time T12, and the initial parameters comprise names of compounds, parent ions and channel ion pairs; a2, method parameters are optimized according to the basic parameters and the initial parameters, and the method parameters comprise method time T21, the fragment number M and fragment scanning time T22; and A3, performing ionization, ion screening, collision and detection by the mass spectrometer according to the parameters of the method. The method has the advantages of good accuracy, high throughput and the like.

The present disclosure provides a solution containing a high-purity ion pair [EDMPC]+[anionic surfactant]-. The solution containing a high-purity ion pair [EDMPC]+[anionic surfactant]- can be obtained by introducing a salt of [EDMPC]+ into an anion exchange resin that has adsorbed the [anionic surfactant]-.

This invention discloses a method for detecting disinfection byproducts in drinking water. By combining gas chromatography-triple quadrupole dynamic multiple reaction monitoring, ion pair information and standard curves containing disinfection byproduct standards are established. The extracted sample solution is tested under the same test conditions, enabling simultaneous extraction and quantitative and qualitative analysis of 34 disinfection byproducts in the sample. The byproducts detected simultaneously include five categories of substances: trihalomethanes, halonitromethanes, haloaldehydes, haloketones, and haloacetonitrs. This greatly increases the variety of disinfection byproducts that can be detected simultaneously and improves the detection efficiency.

The application discloses a silicon-based negative electrode electrolyte, a preparation method and application thereof, and is a novel electrolyte which can form a special solvation structure and stabilize an electrode interface. The electrolyte replaces ester solvents with ether solvents to prevent the reaction between lithiated silicon and carbonates, and selects a single-oxygen ether as a main solvent in the electrolyte. The single-oxygen ether has an ether bond at only one end, so that the solvent molecules have weak coordination with lithium ions, while the anion groups in lithium salts have strong coordination with lithium ions. A contact ion pair (CIP) and an aggregate ion pair (AGG) solvation structure are formed in the electrolyte, more anion groups participate in the SEI process, an interface layer rich in inorganic components is formed on the electrode surface, and the cycle of the electrode is stabilized.

The invention firstly provides a double quaternary ammonium type polyion liquid / quaternary ammonium type polybenzimidazole cross-linked membrane for a high-temperature proton exchange membrane, the mass percentage of the ionic liquid in the composite membrane is 30%, the prepared QMPBI-P-Ox-Ty membrane exchanges anions into H2PO4 <-> through an acid-base doping reaction, so that ion pairs are formed, and the ionic liquid / quaternary ammonium type polybenzimidazole cross-linked membrane is used for the high-temperature proton exchange membrane. A proton transfer channel is constructed in a system by the membrane, proton transfer and transfer are promoted, an alkaline quaternary ammonium site is provided, the alkaline quaternary ammonium site and PA have relatively strong acid-base interaction, and PA leakage can be effectively reduced. The long-term performance of the high-temperature proton exchange membrane can be enhanced. The invention further provides a preparation method of the double quaternary ammonium type polyion liquid / quaternary ammonium type polybenzimidazole cross-linked membrane for the high-temperature proton exchange membrane. The QMPBI-P-Ox-Ty membrane is formed by cross-linking through an in-situ free radical polymerization method. The formed high-temperature proton exchange membrane is excellent in electrochemical performance and controllable in cost, has a production prospect and can be applied to the field of high-temperature proton exchange membrane fuel cells.

Compositions, methods of production, methods of use, and systems for humidity swing adsorbents can be applied to capture carbon dioxide or other target chemicals from air or other gas streams. The compositions, methods, and systems may use a humidity swing sorbent comprising a sorbent support layer of an oxide nanoparticle material or nanoporous material and a capture layer comprising a set of neutral ion pairs having at least one cation and at least one anion, wherein the set of neutral ion pairs is spatially distributed over the scaffold of oxide material such that the anions of each neutral ion pair are spaced apart to form a hydrated shell around each anion wherein the hydrated shell around the anions is a carbon dioxide adsorption site.

The invention provides a preparation method of composite ion pair modified potassium-sodium niobate ceramic, and relates to the technical field of functional ceramic. The chemical general formula of the composite ion pair modified potassium-sodium niobate ceramic is (K0. 5Na0. 5) 1-x (H-V) xNbO3, H-V is a composite ion pair, x is the mole fraction of the composite ion pair, and 0 lt; x is smaller than or equal to 0.05; the composite ion pair H-V is composed of a positive ion H and an equivalent A-site vacancy V, and is used for jointly replacing A-site (K0. 5Na0. 5) 1 + in the chemical general formula and keeping the electricity price balance of a crystal structure. The potassium-sodium niobate ceramic material disclosed by the invention has excellent piezoelectric property, and the maximum piezoelectric coefficient is about 560 pC / N. The performance index is far superior to the electrical performance of pure potassium sodium niobate ceramic, and is also superior to numerous commercial lead-containing PZT piezoelectric ceramics.

The application discloses an electrolyte, a secondary battery and a power utilization device, and belongs to the technical field of new energy sources. The application adds a specific halogenated tertiary butyl ether diluent in the electrolyte, ensures that the electrolyte inherits the contact ion pair and ion aggregate solvation structure characteristics of high-concentration electrolyte, effectively reduces the viscosity of the electrolyte, improves the flame retardancy of the electrolyte, and induces the production of LiF and other halides of Li at the interface between the electrode and the electrolyte. The LiF can make the mechanical strength and compactness of the interface film higher, prevent the electrolyte and the electrode from continuously reacting, and inhibit the generation of lithium dendrites. The other halides of Li have a lower ion diffusion barrier, can promote the transmission behavior of lithium ions at the interface, and improve the rate performance of the battery.

The invention discloses an identification method of glycosylated nucleic acid glycans based on solid-phase positive ion pairing enrichment, which solves the key technical problems of nucleic acid glycosylation analysis through an innovative two-stage strategy system: in the first stage, based on unique phosphoric acid skeleton characteristics of nucleic acid molecules, a specific cationic ligand and a solid-phase carrier are designed; selective capture of glycoDNA and glycoRNA is realized through high-affinity ionic bond combination, and the design breaks through the problem of low enrichment efficiency caused by strong electronegativity of DNA / RNA in a traditional method; in the second stage, an integrated glycan analysis process is constructed, firstly, easy-to-degrade sialic acid modification is stabilized through a chemical protection strategy, then specific enzyme digestion is performed by using glycosidase to release complete glycan (Glycan), and finally, accurate quantification of glycan composition and abundance is realized by combining high-sensitivity mass spectrometry.

The disclosure provides a composition configured for oral use, the composition including at least one filler, water, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof, wherein the organic acid has a log P value of from about 1 to about 12. At least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof. The association is in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or a combination of both. The organic acid is a monoester of a dicarboxylic acid or is a carotenoid derivative having one or more carboxylic acids.

The disclosure provides compositions configured for oral use, the compositions including at least one filler, water, a basic amine, and an organic acid, an alkali metal salt of an organic acid, or a combination thereof, wherein the organic acid has a logP value of from about 1.4 to about 8.0. At least a portion of the basic amine is associated with at least a portion of the organic acid or the alkali metal salt thereof. The association is in the form of a basic amine-organic acid salt, an ion pair between the basic amine and a conjugate base of the organic acid, or a combination of both. Further provided are methods for stabilizing a composition configured for oral use and for enhancing a predicted buccal absorption of a composition configured for oral use.