Trimebutine maleate injection and preparation method thereof

Abstract

The present invention relates to a trimebutine maleate injection and a preparation method thereof. The trimebutine maleate injection comprises a pharmaceutical active component of trimebutine maleate, and an additional preparation adjuvant, wherein 1 ml of the trimebutine maleate injection contains 5-20 mg of the trimebutine maleate, the additional preparation adjuvant comprises 0.1-2% of an analgesics, 0.5-1.5% of an osmotic pressure regulator, and the balance of water. The trimebutine maleate injection of the present invention has characteristics of quick onset, first pass effect-free property, high bioavailability and simple preparation method.

Description

Technical field

[0001] The invention relates to the field of pharmaceutical preparations, in particular to trimebutine maleate injection and a preparation method thereof. Background technique

[0002] Trimebutine maleate is a gastrointestinal rhythm regulator different from cholinergic drugs and antidopamine drugs. It is clinically used to treat gastrointestinal symptoms caused by chronic gastritis (abdominal fullness, abdominal pain, Nausea, heating) and irritable bowel syndrome.

[0003] The relevant characteristics of trimebutine maleate are as follows:

[0004] 1. Unlike other digestive system drugs, for digestive tract movement, due to the difference in the physiological state of the digestive tract, it can promote or inhibit the two-way effect of normalizing the abnormal movement of the digestive tract;

[0005] 2. It can promote gastric emptying;

[0006] 3. It can relieve gastritis, peptic ulcer, irritable bowel syndrome and other gastrointestinal symptoms, especially abdomina...