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Compound preparation containing mesalazine and acetaminophen, and application thereof

A technology for paracetamol and compound preparations is applied in the field of compound preparations containing mesalazine and paracetamol to achieve the effects of enhancing therapeutic effect, relieving pain and ensuring effective dose

Inactive Publication Date: 2019-05-03
重庆健能医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both mesalamine and acetaminophen have been clinically used for many years, and have very definite clinical therapeutic effects. However, the two drugs are made into a compound preparation, so that it can not only treat ulcerative colitis, but also relieve abdominal pain or adverse reactions of patients The pain caused has not been reported at home and abroad

Method used

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  • Compound preparation containing mesalazine and acetaminophen, and application thereof
  • Compound preparation containing mesalazine and acetaminophen, and application thereof
  • Compound preparation containing mesalazine and acetaminophen, and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Preparation Process:

[0027] (1) Get about 45g of new boiling water, add disodium edetate, sodium benzoate and potassium acetate of recipe quantity successively, stir until dissolved.

[0028] (2) Slowly add the xanthan gum and carbomer of the recipe amount under stirring, and stir to swell.

[0029] (3) Add sodium sulfite, mesalazine and acetaminophen in the prescribed amounts, stir and mix well.

[0030] (4) Homogenize, add new boiling water to the full amount, stir evenly, and fill.

Embodiment 2

[0032]

[0033] Preparation Process:

[0034] (1) Get about 45g of new boiling water, add disodium edetate, potassium benzoate and potassium sodium acetate of recipe quantity successively, stir until dissolved.

[0035] (2) Slowly add the xanthan gum and carbomer of the recipe amount under stirring, and stir to swell.

[0036] (3) Add sodium metabisulfite, mesalazine and paracetamol in the prescribed amounts, stir and mix well.

[0037] (4) Homogenize, add new boiling water to the full amount, stir evenly, and fill.

Embodiment 3

[0039]

[0040] Preparation Process:

[0041] (1) Get about 45g of new boiling water, add disodium edetate, potassium benzoate and potassium sodium acetate of recipe quantity successively, stir until dissolved.

[0042] (2) Slowly add the xanthan gum and carbomer of the recipe amount under stirring, and stir to swell.

[0043] (3) Add potassium metabisulfite, mesalazine and paracetamol in the prescribed amounts, stir and mix well.

[0044] (4) Homogenize, add new boiling water to the full amount, stir evenly, and fill.

[0045] Example 2

[0046] 1. Purpose of the test

[0047] Through the test, the improvement of symptoms of mice after using the medicine of the present invention and the medicine of the control group was observed.

[0048] 2. Test materials

[0049] 1. Tested drugs: medicine of the present invention, mesalazine enema solution (registration number H20150127), mesalazine suppository (national medicine approved character H20065650), mesalazine enteric-coa...

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PUM

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Abstract

The invention provides a compound preparation containing mesalazine and acetaminophen. The compound preparation is an enema, which comprises 4 g of mesalazine, 0.2-0.65 g of acetaminophen, 0.04-0.1 gof a metal chelator, 0.1-0.5 g of an antioxidant, 0.01-0.2 g of a preservative, 0.1-0.4 g of a suspending agent, 0.1-0.4 g of a pH regulator, and the balance of purified water to 60g. The invention also provides a preparation method and application of the above compound preparation. The compound preparation has stable and uniform product quality, improves the effectiveness and safety of patient'smedication, has good therapeutic effect on ulcerative colitis and has good analgesic effect.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a compound preparation containing mesalazine and paracetamol and uses thereof. Background technique [0002] Ulcerative colitis is a chronic, non-specific intestinal inflammatory disease of unknown etiology, with lesions confined to the mucosa and submucosa of the large intestine. The main clinical manifestations are mucus pus and bloody stool, abdominal pain, and diffuse and transmural inflammation and ulcers of the intestinal tract. [0003] At present, western medicines for the treatment of ulcerative colitis mainly include aminosalicylic acids, glucocorticoids, immunosuppressants and probiotics. Commonly used aminosalicylic acids include sulfasalazine, mesalazine, etc., which are the first choice for patients with mild to moderate ulcerative colitis in active stage. [0004] Mesalazine, as a common drug for the treatment of ulcerative colitis, is widely used in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/167A61K31/606A61P1/04A61P1/00
Inventor 王国华王鹏飞王祖焕倪菁
Owner 重庆健能医药开发有限公司
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