Traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as preparation and preparation method thereof

A technology of gastrointestinal peristalsis and extract, which is applied in the field of Chinese veterinary drug extract, can solve the problems that the drug is easily affected by the contents of the digestive tract, the first-pass effect of the liver is large, and the dosage is difficult to control, so as to achieve good application prospects and accurate dosage , quick effect

Inactive Publication Date: 2010-08-04
SOUTHWEST UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional Chinese veterinary drug preparations for the treatment of dyspepsia recorded in the Chinese Veterinary Pharmacopoeia in 2005 are mainly oral solid preparations such as powders and granules, which are inconvenient to pour and easily cause foreign body pneumonia in animals, and the dosage is difficult to control; the drugs are easily affected by the content of the digestive tract. The influence of drugs, the first-pass effect of the liver is relatively large, the bioavailability is low, and the onset is slow, etc.
At present, there is no Chinese veterinary drug injection for the treatment of dyspepsia in the market.

Method used

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  • Traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as preparation and preparation method thereof
  • Traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as preparation and preparation method thereof
  • Traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1, the Chinese veterinary medicine extract that promotes gastrointestinal peristalsis

[0024] Prescription: betel nut 100g, hawthorn 100g, amomum 100g

[0025] Preparation method: Preparation of betel nut ethanol extract: take 100 g of betel nut tablets, add 400 mL of ethanol with a volume percentage of 95%, soak at room temperature for 24 hours, reflux for 2 hours, and collect the extract; 400mL of 75% ethanol was refluxed twice, each time for 1 hour, filtered, and the extract was collected; the three extracts were combined, filtered, the filtrate recovered ethanol and concentrated to 100mL, adjusted to pH 4.0 with hydrobromic acid, filtered, Add 100 mL of water to the filtrate, stir evenly, refrigerate and stand for 12 hours, filter out the precipitate, then concentrate the filtrate to 100 mL, add 100 mL of water, stir well, refrigerate and stand for 12 hours, filter out the precipitate, and concentrate the filtrate to dryness under reduced pressure to obt...

Embodiment 2

[0028] Embodiment 2, the Chinese veterinary medicine injection that promotes gastrointestinal peristalsis

[0029]Prescription: alcoholic extract of betel nut 100g, water extract of hawthorn 100g, volatile oil of amomum 100g; polysorbate 800.5mL, sodium bisulfite 0.2g, cresol 0.3mL, edetate disodium 0.015g, Add 0.1-0.3 mL of ethanolamine and water for injection to 100 mL.

[0030] Preparation method: Take the prescribed amount of alcoholic extract of betel nut and water extract of hawthorn, add 90mL of water for injection, stir well to dissolve, let stand at 4°C for 24 hours, filter, add 1g of activated carbon powder to the filtrate, decoct for 15 minutes, and keep warm Filter and cool the filtrate to 60°C for later use; take another prescribed amount of polysorbate 80 and grind it finely in a mortar, slowly add the prescribed amount of amomum volatile oil, grind evenly, then slowly add the above-mentioned 60°C heat preservation solution, grind and emulsify, and then Add the ...

Embodiment 3

[0032] Embodiment 3, the Chinese veterinary drug injection that promotes gastrointestinal peristalsis

[0033] Prescription: alcoholic extract of betel nut 100g, water extract of hawthorn 100g, volatile oil of amomum 100g; polysorbate 80 1.0mL, sodium bisulfite 0.2g, cresol 0.3mL, disodium edetate 0.015g , ethanolamine 0.1 ~ 0.3mL, water for injection to 100mL.

[0034] Preparation method: basically the same as the preparation method described in Example 2, except that ethanolamine is used to adjust the pH to 4.9.

[0035] Quality: The obtained injection is dark red clear liquid; Accelerated test and long-term test were carried out according to the guiding principles of veterinary drug stability test in the first appendix of the Chinese Veterinary Pharmacopoeia in 2005, and the results showed that the product had good stability and the validity period was 2.54 years.

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Abstract

The invention discloses a traditional Chinese veterinary medicine extract for promoting gastrointestinal peristalsis as well as a preparation and a preparation method thereof. The extract comprises the following extracts of raw materials in parts by weight: 1 part of areca nut ethanol extract, 1 part of hawthorn aqueous extract and 1 part of fructus amomi volatile oil; the preparation of the extract is injection liquid and comprises the extract and pharmaceutically acceptable vectors; and the preparation method comprises the following steps of: dissolving the areca nut ethanol extract and the hawthorn aqueous extract by adding water, standing, filtering, decoloring filtrate by using activated carbon and then cooling to 60 DEG C for later use; slowly adding the fructus amomi volatile oil, evenly grinding, then slowly adding 60-DEG C insulating liquid, grinding and emulsifying, then adding an antioxidant, a bacteriostatic agent, a metal chelating agent and water for injecting, regulating pH to be 4.5 to 5.5 by using a pH regulating agent, standing, filtering, encapsulating and sterilizing to obtain the product. The extract and the preparation thereof have remarkable effect of prompting the gastrointestinal peristalsis, are simple in preparation method, low in cost and can be used for treating livestock indigestion.

Description

technical field [0001] The invention relates to an extract of traditional Chinese veterinary medicine, in particular to an extract of Chinese veterinary medicine for promoting gastrointestinal peristalsis and its preparation, and also relates to a preparation method of the preparation. Background technique [0002] Traditional Chinese medicine is a precious wealth accumulated by the Chinese nation in the long-term struggle against diseases. On the basis of inheriting and carrying forward the advantages and characteristics of traditional Chinese medicine, we should make full use of modern science and technology to promote the modernization and internationalization of traditional Chinese medicine, so as to meet the development of the times and the increasing medical and health care needs of the people, which is the responsibility entrusted to us by history. The Outline of the Innovation and Development Plan of Traditional Chinese Medicine (2006-2020) pointed out that the devel...

Claims

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Application Information

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IPC IPC(8): A61K36/9064A61P1/14
Inventor 黎晓敏杨建省罗永煌王健张哲操武能杨怡田朋鑫
Owner SOUTHWEST UNIVERSITY
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