Senso fat-soluble extract dry powder inhalation, preparation method and application thereof

The technology of dry powder inhaler and dry powder inhaler is applied in the application field of preparing drugs for treating lung tumors, can solve problems such as no reports, and achieve the effects of improving drug concentration, fast onset of effect and convenient application.

Active Publication Date: 2011-10-12
南通海睿知新信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the study of dry powder inhalation of the fat-soluble extract of toadseye with anti-lung tumor effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Preparation of toad venom fat-soluble extract: take toad venom and wash it, add 10 times the amount of 95% (W / W) ethanol, reflux twice for 1.5 hours each time, combine the filtrate after filtration, recover ethanol, concentrate to a thick paste, Dry at 60°C to obtain the fat-soluble extract of Bufoni.

[0025] 2. Preparation of the inhalant: the fat-soluble extract of Buad Phae is pulverized to D 50 Below 6 microns, mix with lactose with a particle size of 50-80 microns at a mass ratio of 1:12, pack the drug powder into capsules or blisters or dry powder inhalers to obtain inhalants.

Embodiment 2

[0027] 1. Preparation of toad venom fat-soluble extract: take toad venom and wash it, add 12 times the amount of 95% (W / W) ethanol, reflux twice for 2 hours each time, combine the extracts and filter, concentrate the filtrate and spray dry , to obtain the fat-soluble extract powder of Bufoni, powder D 50 Below 5 microns.

[0028] 2. Preparation of the inhalant: Mix the fat-soluble extract powder of Bufoni Bubani, lactose with a particle size of 80-125 microns, and leucine with a particle size of 30-50 microns in a mass ratio of 9:100:1, and pack Inhalers are obtained in capsules or blisters or dry powder inhalers.

Embodiment 3

[0030] 1. Preparation of the fat-soluble extract of toad venom: take toad venom and wash it, add 30 times the amount of 70% (W / W) ethanol, microwave-assisted extraction 3 times, each time for 1 hour, combine the extracts and filter, concentrate the filtrate and carry out Spray drying to obtain the fat-soluble extract powder of Bufoni, powder D 50 Below 5 microns.

[0031] 2. Preparation of the inhaler: packing the powder of the fat-soluble extract of toadseye into capsules, blisters or dry powder inhalers to obtain the inhaler.

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Abstract

The invention relates to dry powder inhalation, in particular to the dry powder inhalation prepared by senso fat-soluble extract, a preparation method of the dry powder inhalation and application in preparing a medicament for treating lung tumors. The senso fat-soluble extract dry powder inhalation is characterized by consisting of senso fat-soluble extract and pharmaceutically acceptable auxiliaries in the mass ratio of 1:0-1:100. The senso fat-soluble extract is made into the dry powder inhalation, and can directly act on a lung focus to reduce occurrence of toxic and side effects and improve the bioavailability of the medicament, so that the defects of slow response, first pass effect of hepar and systemic toxic and side effect, low bioavailability and the like of oral preparations canbe overcome, and the problems of inconvenient use of injection, poor patient compliance and the like can be solved.

Description

Technical field: [0001] The invention relates to a dry powder inhaler, in particular to a dry powder inhaler made of venom fat-soluble extract, a preparation method of the dry powder inhaler and an application in the preparation of a drug for treating lung tumors. Background technique: [0002] Toad Su is the secretion of the epidermal glands of Bufobufo gargarizans Cantor, an animal of the Bufonidae family. It has multiple functions such as detoxification, analgesia, resuscitation, and anti-tumor. It is used for middle and late stage tumors, chronic hepatitis B and other diseases. . Bufotoxins and their hydrolysis products, bufageins and bufoteinines, have anti-tumor effects in toad venom. At present, the oral liquid and tablet containing toad venom extract have been used clinically, and have good curative effects on liver cancer, lung cancer, gastric cancer, etc., and have synergistic effects on chemotherapy and radiotherapy. Although the fat-soluble extract of toadseye ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/14A61K47/26A61K47/34A61K47/36A61K47/42A61P35/00A61K35/65
Inventor 陈彦张振海贾晓斌吴青青周蕾
Owner 南通海睿知新信息科技有限公司
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