Medicine of erdosteine composition capsule for treating airway inflammation

A technology of erdosteine ​​and a composition is applied in the field of drug erdosteine ​​composition capsules for treating respiratory tract inflammation, and can solve the problems of drug absorption speed or degree, poor water solubility of erdosteine, and low effective bioavailability and other problems, to achieve the effect of suitable for clinical application, good stability and high stability

Inactive Publication Date: 2015-12-02
杨献美
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Erdosteine ​​has poor water solubility and low effective bioavailability in the human body, and the absorption rate of the drug in the body is often determined by the speed of dissolution. The drug in the solid preparation must be disintegrated and dissolved before being absorbed. Then the process of turning into a solution, if the drug is not easily released from the formulation or the drug dis

Method used

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  • Medicine of erdosteine composition capsule for treating airway inflammation
  • Medicine of erdosteine composition capsule for treating airway inflammation
  • Medicine of erdosteine composition capsule for treating airway inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1: Preparation of Erdosteine ​​Crystals

[0032] (1) Take erdosteine ​​raw material, add it into deionized water at 50°C, and the volume of deionized water is 5 times the mass of erdosteine;

[0033] (2) Stir until completely dissolved;

[0034] (3) Add activated carbon for decolorization and filter to obtain a clear solution;

[0035] (4) Move the clarified solution into a pressure vessel, add isopropanol dropwise at 5°C under the condition of controlling the pressure in the pressure vessel at 1.0Mpa and stirring, the stirring speed is 35rmp, and the volume of isopropanol is deionized 5 times the volume of water;

[0036] (5) Release the pressure after the dropwise addition, cool the solution to -5°C at a rate of 10°C / min, let it stand for 2 hours, filter, wash, and dry under reduced pressure to obtain erdosteine ​​crystals.

[0037] The X-ray powder diffraction pattern obtained by measuring the obtained erdosteine ​​crystal using Cu-Kα ray is as follows: ...

Embodiment 2

[0038] Example 2: Preparation of Erdosteine ​​Capsules

[0039] Prescription: 1.5 parts by weight of the erdosteine ​​crystal compound prepared in Example 1, 1.5 parts by weight of starch, 0.08 parts by weight of nordihydroguaiaretic acid, 0.7 parts by weight of 95% ethanol, 0.04 parts by weight The talcum powder of povidone K30, 0.03 parts by weight.

[0040] Preparation:

[0041] (1) Processing of raw and auxiliary materials: sieve erdosteine ​​and nordihydroguaiaretic acid to 80 mesh;

[0042] (2) Weighing: Weighing according to the prescription;

[0043] (3) Adhesive preparation: dissolve the prescribed amount of povidone K30 in 95% ethanol and set aside;

[0044] (4) Granulation: add erdosteine, starch, and nordihydroguaiaretic acid into the wet mixing granulator, and dry mix for 10 minutes; add the prepared binder and wet mix and cut 2- 3min, 18 mesh granulation soft material;

[0045] (5) Drying: Spread the wet granules obtained from granulation evenly on the bak...

Embodiment 3

[0049] Example 3: Preparation of Erdosteine ​​Capsules

[0050] Prescription: 1.5 parts by weight of the erdosteine ​​crystal compound prepared in Example 1, 1.6 parts by weight of starch, 0.1 parts by weight of nordihydroguaiaretic acid, 0.8 parts by weight of 95% ethanol, 0.05 parts by weight The talcum powder of povidone K30, 0.04 parts by weight.

[0051] Preparation:

[0052](1) Processing of raw and auxiliary materials: sieve erdosteine ​​and nordihydroguaiaretic acid to 80 mesh;

[0053] (2) Weighing: Weighing according to the prescription;

[0054] (3) Adhesive preparation: dissolve the prescribed amount of povidone K30 in 95% ethanol and set aside;

[0055] (4) Granulation: add erdosteine, starch, and nordihydroguaiaretic acid into the wet mixing granulator, and dry mix for 10 minutes; add the prepared binder and wet mix and cut 2- 3min, 18 mesh granulation soft material;

[0056] (5) Drying: Spread the wet granules obtained from granulation evenly on the bakin...

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Abstract

The invention discloses medicine of an erdosteine composition capsule for treating airway inflammation, and belongs to the technical field of medicine. The erdosteine composition capsule is prepared from erdosteine, starch, nordihydroguaiaretic acid, 95-percent ethanol, polyvidone K30 and talcum. The erdosteine is a novel crystal form compound; an X-ray powder diffraction pattern obtained through Cu-Ka ray measurement is shown as a Figure 1; the medicine belongs to the erdosteine different from that reported in the prior art. Experiments show that the erdosteine novel crystal form compound has better solubility and higher stability; the prepared capsule has high dissolution rate and good stability, and is very suitable for clinic application.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a capsule of erdosteine ​​composition for treating respiratory inflammation. Background technique [0002] Phlegm is the product of respiratory inflammation, which can irritate the respiratory mucosa, cause cough and asthma, and aggravate infection. When patients with acute and chronic bronchitis or chronic lung disease have respiratory failure, if the patient's sputum is too viscous or forms sputum plugs, it can block the airway and cause suffocation. Therefore, it is of great significance to use mucus sputum regulators to dissolve mucus sputum, make it thinner, lower its viscosity, accelerate the movement of mucous membranes and cilia in the respiratory tract, and improve the transport function. [0003] The currently marketed mucus regulators, such as bromhexine, sodium thioethanesulfonate, and carbocysteine, all have varying degrees of mucus regulation, but they have some pha...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/381C07D333/36A61P11/12A61P11/00A61P39/06A61K47/36
Inventor 杨献美
Owner 杨献美
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