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Pharmaceutical composition taking cefixime and erdosteine as active component as well as preparation method and usage thereof

A technology of cefixime and active ingredients, which is applied in the field of medicine, and can solve the problems of compound cefixime and erdosteine ​​related literature and patent reports, etc.

Inactive Publication Date: 2008-05-21
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Through the search, there are no related literature and patent reports about compound cefixime and erdosteine

Method used

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  • Pharmaceutical composition taking cefixime and erdosteine as active component as well as preparation method and usage thereof
  • Pharmaceutical composition taking cefixime and erdosteine as active component as well as preparation method and usage thereof
  • Pharmaceutical composition taking cefixime and erdosteine as active component as well as preparation method and usage thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Cefixime and Erdosteine ​​Tablets

[0015] prescription:

[0016]

[0017] Preparation:

[0018] Pass erdosteine ​​and microcrystalline cellulose through 80-mesh sieve respectively, mix evenly, add 50% ethanol solution to the mixed powder, make soft material, granulate with 24-mesh sieve, dry, granulate with 20-mesh sieve, add micropowder silica gel , CMS-Na, after mixing evenly, use a suitable die to compress the tablet, that is to say.

[0019] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the like.

Embodiment 2

[0020] Embodiment 2: Cefixime and Erdosteine ​​Capsules

[0021] prescription:

[0022]

[0023] Preparation:

[0024] Pass erdosteine ​​and cefixime through an 80-mesh sieve, and after mixing evenly, add magnesium stearate, mix evenly, and pack separately to obtain the product.

[0025] The used capsule shell can be a common capsule or an enteric-coated capsule.

Embodiment 3

[0026] Example 3: Cefixime and Erdosteine ​​Chewable Tablets

[0027] prescription:

[0028]

[0029] Preparation:

[0030] Pass erdosteine, cefixime, xylitol, mannitol and other raw and auxiliary materials through a 80-mesh sieve respectively, and mix them uniformly by using an equal-volume increasing method. granules, dried, sieved through a 20-mesh sieve, added other flavoring agents, sweeteners, and glidants, mixed evenly, and compressed into tablets.

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PUM

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Abstract

The invention relates to a pharmaceutical composition which takes cefixime and erdosteine as active ingredients, the preparation method and the usage. The invention takes cefixime and erdosteine as the pharmaceutical active ingredients, pharmaceutically acceptable excipients are mixed to form the pharmaceutical composition, and the invention can be used for the treatment of chronic bronchitis with cough, sputum and other clinical symptoms. The contents of the invention take cefixime and erdosteine as raw materials, certain specific type and proportion of excipients are added, the invention is prepared and developed into tablets, capsules, granules, dispersion tablets, chew tablets, buccal tablets, effervescent tablets, effervescent granules and other various oral preparations according to the technical means which is illustrated by the invention.

Description

technical field [0001] The invention relates to a pharmaceutical composition with cefixime and erdosteine ​​as active components, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] The antibacterial mechanism of cefixime is similar to that of other third-generation cephalosporins. By binding to one or more penicillin-binding proteins (PBPs), it inhibits the cell wall synthesis of bacterial dividing cells and makes bacteria form defective cell walls that are unstable to osmotic pressure. , thereby playing an antibacterial effect. Its antibacterial spectrum includes Streptococcus, Streptococcus pneumoniae, Neisseria gonorrhoeae, Escherichia coli, Klebsiella, Brahamella catarrhalis, Serratia, Citrobacter, Enterobacter cloacae, Enterobacter aerogenes, Haemophilus influenzae Bacillus, etc., can be used for respiratory infections caused by sensitive bacteria, such as pneumonia, bronchitis, etc. [0003] Erd...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K9/20A61K9/46A61K9/48A61P11/10A61P11/14A61K31/381
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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