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Combination containing clacillin or derivative and preparing method thereof

A technology of cyclohexicillin and composition, which is applied in the field of medicine and can solve problems such as poor antibacterial activity

Inactive Publication Date: 2008-06-18
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect on penicillinase-producing Staphylococcus aureus is 2 times stronger than that of ampicillin; while the antibacterial activity against other bacteria is poor

Method used

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  • Combination containing clacillin or derivative and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 cyclohexicillin and ambroxol hydrochloride tablet

[0029] prescription:

[0030] components

Dosage

Cyclohexacillin Sodium

Ambroxol hydrochloride

microcrystalline cellulose

CMS-Na

Micropowder silica gel

Co-made

250g (calculated based on the active ingredient cyclohexicillin)

30g

90g

5g

5g

1000 pieces

[0031] Preparation:

[0032] Pass cyclohexicillin, ambroxol hydrochloride, and microcrystalline cellulose through a 80-mesh sieve, mix well, and set aside; another appropriate amount of 50% ethanol solution is used as a binder soft material, granulated with a 24-mesh sieve, and dried at 50°C , 20-mesh sieve, add micropowder silica gel, CMS-Na, mix evenly, and press a suitable die to form a tablet.

[0033] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the ...

Embodiment 2

[0034] Example 2: Cyclohexicillin and Acetylcysteine ​​Granules

[0035] prescription:

[0036] components

Dosage

Cyclohexacillin pivaloyloxymethyl ester

Acetylcysteine ​​

sucrose

Sweet Orange Powder Flavor

Co-made

250g (calculated based on the active ingredient cyclohexicillin)

300g

1430g

20g

1000 bags

[0037] Preparation:

[0038] Mix cyclohexicillin and part of sucrose powder evenly, use purified water to make soft material, granulate with 18 mesh, dry, granulate with 16 mesh, and set aside; in addition, acetylcysteine ​​and sucrose crystals are sieved with 16 mesh respectively particles to obtain crystal particles. Mix the above three kinds of granules, add sweet orange powder essence and pack them separately to get the product.

Embodiment 3

[0039] Example 3: Cyclohexicillin and Carbocisteine ​​Chewable Tablets

[0040] prescription:

[0041] components

Dosage

Cyclohexicillin

carbocisteine

Xylitol

Sweet Orange Powder Flavor

Ansai K

Co-made

250g (calculated based on the active ingredient cyclohexicillin)

500g

650g

25g

25g

1000 pieces

[0042] Preparation:

[0043] Grind cyclohexicillin, carbocisteine, and xylitol and mix them evenly, use 2% starch slurry to make soft material, granulate with a 16-mesh sieve, dry, granulate with a 12-mesh sieve, add sweet orange powder essence and acesulfame potassium , fully mix evenly, adjust the weight of the content, and press it.

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PUM

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Abstract

The invention relates to a series of combined substances which contain cyclacillin or derivative of the cyclacillin, in particular to a combined substance where the cyclacillin or the derivative of the cyclacillin and an expectorant are combined. Wherein, the derivative of the cyclacillin is medicine salt or medicine ester of the cyclacillin; and the expectorant is any of ambroxol, acetylcysteine, carbocisteine, erdosteine, fudosteine and guaiacum glycerol ether. The drug dosage per unit of the cyclacillin is in preference to 0.25g to 0.5g ( the content is calculated according to active components). The drug dosage per unit of the expectorant is 0.01 to 2.0g. The combined substance is mainly used to treat respiratory tract infection with expectoration symptom.

Description

technical field [0001] The invention relates to a series of compositions containing cyclohexicillin or derivatives thereof and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The structural formula of cyclohexicillin is as follows: [0003] [0004] Cyclohexicillin is a broad-spectrum semi-synthetic penicillin, and its antibacterial spectrum and antibacterial activity are similar to ampicillin. [0005] The effect of ampicillin on Gram-positive bacteria is similar to that of penicillin G, and its effect on Streptococcus viridans and Enterococcus is better, but its effect on other bacteria is poor. Ineffective against penicillin G-resistant Staphylococcus aureus. Among Gram-negative bacteria, Neisseria gonorrhoeae, meningococcus, influenza bacillus, pertussis bacillus, Escherichia coli, typhoid paratyphoid bacillus, Shigella bacillus, Proteus mirabilis, Brucella, etc. are sensitive to this product, but are prone t...

Claims

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Application Information

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IPC IPC(8): A61K31/43A61K45/06A61P11/10A61K31/09A61K31/137A61K31/198A61K31/381
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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