The invention relates to a production technique of fudosteine. The production technique comprises the following steps: dissolving L-cysteine in purified water by stirring, adding potassium persulfate and propenol, and stirring to react for 5+/-1 hours while controlling the temperature at 30+/-2 DEG C; distilling under reduced pressure to remove the solvent; adding ethanol into the residues, stirring for 1.5 hours, and filtering to remove insoluble substances; concentrating the filtrate until a small amount of solid precipitates, and stopping concentrating; cooling, crystallizing by stirring at 30+/-2 DEG C for 3+/-1 hours until abundant white solid appears, and carrying out centrifugal filtration; washing the filter cake with anhydrous ethanol twice, and drying to obtain a fudosteine crude product; and refining and drying to obtain the fudosteine. By using ethanol-water as the solvent, the technique has the advantages of high use safety, low cost, mild reaction conditions and high atom economic benefit, and conforms to the requirements for green chemistry. The product yield is up to 95% or above, the content is up to 99.9%, and the maximum single impurity content is lower than 0.01%. Besides, the technique reduces the occupational hazards for employees, and is more beneficial to mass production.