Fudosteine solution preparation for atomization inhalation, and preparation method thereof

Abstract

The invention provides a fudosteine solution preparation for atomization inhalation, and a preparation method thereof. A single dose of the fudosteine solution preparation for atomization inhalation comprises the following components: 20-120 mg of fudosteine or a salt and / or a hydrate thereof (based on free fudosteine), 0.5-2 mg of a metal complexing agent, an appropriate amount of a pH regulatorand water for injection. The prepared fudosteine solution preparation for atomization inhalation has the characteristics of high efficiency, low toxicity, good stability and high safety, and is used for treatment of sputum stickiness, expectoration difficulty and phlegm obstruction of trachea and other diseases caused by chronic bronchitis, bronchial asthma and other diseases.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a fudosteine ​​atomized solution preparation for inhalation and a preparation method thereof. Background technique [0002] Due to factors such as dense population, large number of smokers and environmental pollution, the morbidity and mortality of respiratory diseases have remained high in recent years. The cause of death (excluding tumors) rose from 10th in 1970 to 4th (chronic obstructive pulmonary disease) and 8th (pneumonia, influenza and upper respiratory tract infection) in 1991, while respiratory diseases in my country The incidence rate of the disease all accounts for the first of many diseases in any age group. This problem has attracted people's attention day by day, so the development of drugs for treating respiratory diseases (respiratory drugs for short) has also become an important research and development field of drug research. [0003] Cough and expect...

AI Technical Summary

Problems solved by technology

However, when it is used together with fillers often used in solid preparations, such as various sugars, cellulose, and sugar alcohols, it will change color, which not only affects the appearance of the sample, but sometimes causes a decrease in the content

[0005] At present, only tablets, granules, and capsules are on the market in China, and most of them are oral preparations, which have poor fluidity and are easy to absorb moisture, which affects the long-term stability of the preparation, and will cause certain damage to the gastrointestinal mucosa when taking them.

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