Fudosteine preparation method

A technology of metallic sodium and liquid ammonia, applied in the preparation of sulfide, organic chemistry, etc., can solve the problems of low production efficiency and high cost, and achieve the effects of low cost, convenient and simple preparation

Inactive Publication Date: 2015-07-01
张云
View PDF0 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low production efficiency and high cost due to Fordostan currently in manufacture

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] Now in conjunction with the present invention for further detailed description.

[0007] A preparation method of fodostan according to the present invention comprises the following specific steps: metal sodium is dissolved in liquid ammonia, cysteine ​​is added, and bromopropanol is added dropwise. The ammonia was evaporated, and the remaining solid was dissolved in 1 mol / L hydrochloric acid, passed through a Dowex50 (H+) column, eluted with 1 mol / L ammonium hydroxide, and obtained after freeze-drying, fordostan.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a fudosteine preparation method. The method concretely comprises the following steps: dissolving metallic sodium in liquefied ammonia, adding cysteine, and adding bromopropyl alcohol in a dropwise manner; and evaporating ammonia, dissolving the residual solid in 1mol/L of hydrochloric acid, allowing the obtained solution to go through a Dowex50 (H+) column, eluting by using 1mol of ammonium hydroxide, and freeze-drying to obtain fudosteine. The fudosteine preparation method has the advantages of convenient and simple preparation, and low cost.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a preparation method of fodostan. Background technique [0002] Fordostan is white or light yellow crystalline powder, odorless. For the treatment of bronchial asthma, bronchiectasis, chronic bronchitis, tuberculosis, pneumoconiosis, emphysema and other chronic respiratory diseases. Production efficiency is low and cost is high due to Fordostan currently in manufacture. Contents of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a preparation method of fodostan is provided. [0004] The technical solution adopted by the present invention to solve the technical problem is: a preparation method of fodostan, the specific steps are as follows: metal sodium is dissolved in liquid ammonia, cysteine ​​is added, and bromopropanol is added dropwise. The ammonia was evaporated, and the remaini...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C07C319/14C07C323/58
Inventor 张云
Owner 张云
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap