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Fudosteine preparation method

A technology of metallic sodium and liquid ammonia, applied in the preparation of sulfide, organic chemistry, etc., can solve the problems of low production efficiency and high cost, and achieve the effects of low cost, convenient and simple preparation

Inactive Publication Date: 2015-07-01
张云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Low production efficiency and high cost due to Fordostan currently in manufacture

Method used

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Embodiment Construction

[0006] Now in conjunction with the present invention for further detailed description.

[0007] A preparation method of fodostan according to the present invention comprises the following specific steps: metal sodium is dissolved in liquid ammonia, cysteine ​​is added, and bromopropanol is added dropwise. The ammonia was evaporated, and the remaining solid was dissolved in 1 mol / L hydrochloric acid, passed through a Dowex50 (H+) column, eluted with 1 mol / L ammonium hydroxide, and obtained after freeze-drying, fordostan.

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Abstract

The invention relates to a fudosteine preparation method. The method concretely comprises the following steps: dissolving metallic sodium in liquefied ammonia, adding cysteine, and adding bromopropyl alcohol in a dropwise manner; and evaporating ammonia, dissolving the residual solid in 1mol / L of hydrochloric acid, allowing the obtained solution to go through a Dowex50 (H+) column, eluting by using 1mol of ammonium hydroxide, and freeze-drying to obtain fudosteine. The fudosteine preparation method has the advantages of convenient and simple preparation, and low cost.

Description

technical field [0001] The invention relates to the field of medicine preparation, in particular to a preparation method of fodostan. Background technique [0002] Fordostan is white or light yellow crystalline powder, odorless. For the treatment of bronchial asthma, bronchiectasis, chronic bronchitis, tuberculosis, pneumoconiosis, emphysema and other chronic respiratory diseases. Production efficiency is low and cost is high due to Fordostan currently in manufacture. Contents of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a preparation method of fodostan is provided. [0004] The technical solution adopted by the present invention to solve the technical problem is: a preparation method of fodostan, the specific steps are as follows: metal sodium is dissolved in liquid ammonia, cysteine ​​is added, and bromopropanol is added dropwise. The ammonia was evaporated, and the remaini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C319/14C07C323/58
Inventor 张云
Owner 张云
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