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Fudosteine inhalant composition

A technology for dry powder and inhalation of fodosteine, which is applied in the field of medicine, can solve the problem of no fodosteine ​​inhalation drug being marketed and other problems, and achieves the effect of improving the fluidity, good fluidity and smooth surface of the powder.

Inactive Publication Date: 2018-05-29
DISHA PHARMA GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, no fodosteine ​​inhalation drug product is marketed

Method used

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  • Fudosteine inhalant composition
  • Fudosteine inhalant composition
  • Fudosteine inhalant composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] In this embodiment, the HLSH2-6A wet mixing granulator of AVIC Beijing Aeronautical Manufacturing Engineering Research Institute is used.

[0027] Put 10 g of fudosteine ​​with a D90 of 2 μm and 30 g of lactose with a D90 of 50 μm in a high-shear mixer granulator, and mix evenly with a stirring blade at a speed of 300 rpm and a chopping knife at a speed of 900 rpm. Mix for 300 s to prepare fudosteine ​​dry powder inhaler, fill the spray-dried powder into No. 5 capsules to make 400 servings, each containing 80 mg fudosteine ​​dry powder inhaler.

Embodiment 2

[0029] In this embodiment, the HLSH2-6A wet mixing granulator of AVIC Beijing Aeronautical Manufacturing Engineering Research Institute is used.

[0030] Put 13.2 g of fudosteine ​​with a D90 of 3.5 μm and 26.8 g of lactose with a D90 of 50 μm in a high-shear mixer granulator and mix evenly. After 300 s, the fudosteine ​​dry powder inhaler was prepared, and the spray-dried powder was filled in No. 5 capsules to prepare 550 servings, each containing 60 mg of fudosteine ​​dry powder inhaler.

Embodiment 3

[0032] In this embodiment, the HLSH2-6A wet mixing granulator of AVIC Beijing Aeronautical Manufacturing Engineering Research Institute is used.

[0033] Put 16 g of fudosteine ​​with a D90 of 5 μm and 24 g of lactose with a D90 of 50 μm in a high-shear mixer granulator, and mix evenly with a stirring blade at 300 rpm and a chopping knife at 900 rpm. After 300 s, the fudosteine ​​dry powder inhaler was prepared, and the spray-dried powder was filled in No. 5 capsules to prepare 600 servings, each containing 50 mg of fudosteine ​​dry powder inhaler.

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Abstract

The invention belongs to the technical field of medicine, and relates to a fudosteine inhalant and a preparation method thereof. The fudosteine inhalant provided by the invention is prepared from 60 to 90 percent of fudosteine and 10 to 40 percent of lactose, wherein the percentage is the mass percentage; the particle diameter D90 of the fudosteine is preferably 2 mu m to 5 mu m. The invention provides a fudosteine dry powder inhalant with high bioavailability.

Description

technical field [0001] The invention relates to a fudosteine ​​inhalation composition, which belongs to the technical field of medicine. Background technique [0002] Respiratory system disease is one of the diseases that people are familiar with. Respiratory system disease accounts for about 1 / 4 of internal medicine patients and brings mental and physical pain to patients. In my country's population statistics, respiratory system disease is the second cause of death , but there are not many drugs to choose from clinically, and the onset is slow. [0003] Coughing up sputum is a common symptom of respiratory diseases. Increased sputum can stimulate the respiratory mucosa and cause coughing. When sputum blocks the bronchioles, it can not only cause asthma, but also cause secondary infection, further damage the respiratory tract, aggravate cough, expectoration and asthma, and in severe cases, it can inhibit breathing or suffocate to death. Excessive secretion of mucus will ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/72A61K9/14A61K31/198A61K47/26A61P11/10
CPCA61K9/0075A61K9/14A61K31/198A61K47/26
Inventor 岳莉杨德斌苏亮周详彪王江涛
Owner DISHA PHARMA GRP
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