Composition containing ciclacillin or its derivatives and preparation thereof

A technology of cyclohexycillin and composition, applied in the field of medicine, can solve the problems of poor antibacterial activity and the like

Inactive Publication Date: 2008-07-09
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect on penicillinase-producing Staphylococcus aureus is 2 times stronger than that of ampicillin; while the antibacterial activity against other bacteria is poor

Method used

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  • Composition containing ciclacillin or its derivatives and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 cyclohexicillin and ambroxol hydrochloride tablet

[0025] prescription:

[0026] components

Dosage

Cyclohexacillin Sodium

Ambroxol hydrochloride

microcrystalline cellulose

CMS-Na

Micropowder silica gel

Co-made

250g (calculated based on the active ingredient cyclohexicillin)

30g

90g

5g

5g

1000 pieces

[0027] Preparation:

[0028] Pass cyclohexicillin, ambroxol hydrochloride, and microcrystalline cellulose through a 80-mesh sieve, mix well, and set aside; another appropriate amount of 50% ethanol solution is used as a binder soft material, granulated with a 24-mesh sieve, and dried at 50°C , 20-mesh sieve, add micropowder silica gel, CMS-Na, mix evenly, and press a suitable die to form a tablet.

[0029] If the above-mentioned tablet is coated, a coated tablet can be obtained, which can be a film-coated tablet, an enteric-coated tablet, and the ...

Embodiment 2

[0030] Example 2: Cyclohexicillin and Acetylcysteine ​​Granules

[0031] prescription:

[0032] components

Dosage

Cyclohexacillin pivaloyloxymethyl ester

Acetylcysteine ​​

sucrose

Sweet Orange Powder Flavor

Co-made

250g (calculated based on the active ingredient cyclohexicillin)

300g

1430g

20g

1000 bags

[0033] Preparation:

[0034] Mix cyclohexicillin and part of sucrose powder evenly, use purified water to make soft material, granulate with 18 mesh, dry, granulate with 16 mesh, and set aside; in addition, acetylcysteine ​​and sucrose crystals are sieved with 16 mesh respectively particles to obtain crystal particles. Mix the above three kinds of granules, add sweet orange powder essence and pack them separately to get the product.

Embodiment 3

[0035] Example 3: Cyclohexicillin and Carbocisteine ​​Chewable Tablets

[0036] prescription:

[0037] components

Dosage

Cyclohexicillin

carbocisteine

xylitol

Sweet Orange Powder Flavor

Ansai K

Co-made

250g (calculated based on the active ingredient cyclohexicillin)

500g

650g

25g

25g

1000 pieces

[0038] Preparation:

[0039] Grind cyclohexicillin, carbocisteine, and xylitol and mix them evenly, use 2% starch slurry to make soft material, granulate with a 16-mesh sieve, dry, granulate with a 12-mesh sieve, add sweet orange powder essence and acesulfame potassium , fully mix evenly, adjust the weight of the content, and press it.

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PUM

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Abstract

The present invention provides a series of combination which contains ciclacillin or the derivative of the ciclacillin and is the combination essentially consisting of the ciclacillin or the derivative of the ciclacillin and an expectorant drug, wherein, the derivative of the ciclacillin is the officinal salt or officinal ester of the ciclacillin. The expectorant drug is any one of ambroxol, acetylcysteine, carbocisteine, erdosteine, fudosteine and lignum vitae glycerol ether. The unit medication dosage of the ciclacillin is 0.25g to 0.5g which is preferential (counted by active component), and the unit medication dosage of the expectorant drug is 0.01g to 2.0g. The combination is mainly used for remedying the respiratory tract infection with the symptom of expectoration.

Description

technical field [0001] The invention relates to a series of compositions containing cyclohexicillin or derivatives thereof and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] The structural formula of cyclohexicillin is as follows: [0003] [0004] Cyclohexicillin is a broad-spectrum semi-synthetic penicillin, and its antibacterial spectrum and antibacterial activity are similar to ampicillin. This product is acid and enzyme resistant and can be taken orally. It has antibacterial activity against enterococcus, diphtheria bacillus, bacillus anthracis, proteus, influenza bacillus, peptococcus, bacillus perfringens, meningococcus, gonorrhoeae, legionella, etc., but not strong. It has a strong effect on penicillinase-producing Staphylococcus aureus. Oral absorption of cyclohexicillin is rapid and complete. The effect on penicillinase-producing Staphylococcus aureus is 2 times stronger than that of ampicillin; whil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K45/06A61P11/00A61P31/00A61K31/137A61K31/198A61K31/381
Inventor 陈瑞晶
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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