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Drug preparations

A compound preparation and drug technology, which is applied in the direction of drug combination, pill delivery, medical formula, etc., can solve the problems of insufficient curative effect, limited content, unsatisfactory antitussive effect, etc.

Inactive Publication Date: 2004-08-25
SS PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, since the content of ingredients having antitussive effect and ingredients having an expectorant effect contained in commercially available compound preparations of cold medicines is limited, the efficacy of the preparations in antitussive and expectorant effects is insufficient
Commercially available expectorant and antitussive drugs are also not sufficiently effective, especially their antitussive effects are not satisfactory

Method used

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  • Drug preparations

Examples

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preparation example Construction

[0035] The preparation of the drug compound preparation of the present invention is by properly combining the above-mentioned ingredients and pharmaceutically acceptable additives, and making it into oral solid preparations, semi-solid preparations or liquid preparations such as tablets, granules, and microparticles according to conventional methods. formulations, powders, hard capsules, soft capsules, pills, lozenges, drops, suspensions, emulsions, liquid preparations for internal administration, syrups, dry syrups, inhalants or oral patch preparations, etc. Before preparing the above-mentioned preparations, the pharmaceutical ingredients can also be made into microparticles such as microcapsules, nanocapsules, microspheres or nanospheres.

[0036] There is no particular limitation on the method of preparing the drug composite preparation of the present invention. Various methods can be used. For example, when it is necessary to prepare a granular powder for the manufacture ...

Embodiment 1

[0072] tablet:

[0073] Fudosteine ​​(1200 g), dextromethorphan hydrobromide (60 g), corn starch (38 g), talc (1 g) and magnesium stearate (1 g) were prepared into a powder for tableting by a conventional method. The resulting powder was tableted using a rotary tablet machine to prepare tablets each having a diameter of 8.5 mm and a weight of 250 mg.

Embodiment 2

[0075] Liquid formulations:

[0076] Fudosteine ​​(8 g), dextromethorphan hydrobromide (400 mg), erythritol (20 g), caramel (100 mg), sodium benzoate (70 mg) and fragrance (100 mg) were dissolved in purified water. An appropriate amount of phosphoric acid was added to the resulting mixture to adjust its pH, and then pure water was added to the mixture so that the total amount became 100 ml, whereby a liquid preparation was prepared.

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Abstract

Drug preparations characterized by containing fudosteine and an antitussive. These preparations are drugs to be used for common cold, etc. which have improved antitussive and sputum-removal effects.

Description

technical field [0001] The present invention relates to a drug compound preparation, more specifically, relates to a drug compound preparation with antitussive and expectorant effects, and the drug compound preparation can be advantageously used as an antitussive and expectorant drug and other medicaments. Background technique [0002] Since common cold and other diseases are often accompanied by cough and phlegm, ingredients with antitussive effect and ingredients with expectorant effect are usually added to compound preparations for cold medicine in the past. A number of antitussive and expectorant drugs, primarily used for antitussive and expectorant purposes, have also been commercialized. [0003] However, since the content of ingredients having antitussive effect and ingredients having expectorant effect contained in the commercially available compound preparation of cold medicine is limited, the curative effect of the preparation on antitussive and expectorant is insu...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/198A61K31/439A61P11/10A61P11/14
CPCA61K9/1652A61K31/198A61K9/0095A61K9/2059A61K31/439A61P11/10A61P11/14A61K2300/00
Inventor 小贯洋一冈田实坂井裕贵神户英芳水野博之今森胜美
Owner SS PHARMA CO LTD
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