15 results about "Apparent permeability" patented technology

The invention discloses a preparation method of a cochlear organ chip integrated with a blood labyrinth barrier, and belongs to the field of biomedical engineering. The preparation method of the simulated blood labyrinth barrier comprises the following steps: constructing an endothelial cell culture cavity and a pericyte culture cavity, and separating the endothelial cell culture cavity and the pericyte culture cavity through a simulated basement membrane; and respectively inoculating percutaneous cells and endothelial cells into a percutaneous cell culture cavity and an endothelial cell culture cavity, and culturing to obtain the simulated blood lost barrier. The chip can effectively simulate the structure and the function of the BLB, and the barrier integrity of the BLB is evaluated through TEER (trans-epithelial electrical resistance) measurement and an apparent permeability coefficient. The invention also relates to application of the chip in NIHL drug screening, in particular to drug evaluation for oxidative stress induced inner ear organ injury. Through the platform, the protection effect of the candidate drugs on the TBHP-induced oxidative stress injury of the inner ear organs can be evaluated, and a new tool and thought are provided for developing novel NIHL treatment drugs.

The present application relates to the technical field of oil production engineering, and particularly relates to a numerical simulation method for extra-low permeability reservoirs, comprising: sequentially determining the relationship between apparent permeability and throat size, the relationship between apparent permeability and air permeability, and the relationship between the radius of the bulk phase fluid and the pressure gradient, to obtain the relationship between permeability and apparent permeability under the condition of a definite solution; correction of oil-water relative permeability; water injection development is carried out by using a reverse nine-spot well pattern, and simulation is carried out by using Darcy seepage and low-speed non-Darcy equivalent seepage respectively with a month as a time step; fixed liquid production is carried out, and the indicators of the whole region are fitted. The present application analyzes and compares Darcy seepage and non-Darcy seepage by using the numerical simulation method for extra-low permeability reservoirs, obtains the seepage characteristics of the extra-low permeability reservoirs, and provides a guiding role for exploitation and other work.

The invention belongs to the technical field of petroleum and natural gas engineering, and particularly relates to a shale gas reservoir multi-component seepage apparent permeability calculation method which comprises the steps that S1, shale gas reservoir micro-nano pores are equivalent to a channel formed by connecting a plurality of organic pore sections and inorganic pore sections in series, and a seepage physical model is constructed; s2, considering shale gas multi-component composition, and constructing a multi-component gas average molecular free path calculation model; s3, establishing a first apparent permeability calculation equation for inorganic pores; s4, for the organic pores, establishing a second apparent permeability calculation equation; and S5, respectively carrying out scale upgrading on the first apparent permeability and the second apparent permeability, and obtaining the shale multi-component seepage apparent permeability according to the proportion of the organic pores. According to the method, factors such as multi-component gas migration, pore size dynamic change, organic matter multi-component gas competitive adsorption and the like are comprehensively considered, and the shale gas reservoir apparent permeability calculation method integrating the factors is established.

This invention discloses a p-EDFM-based method for evaluating the productivity of marine-continental transitional shale gas. Addressing the vertical heterogeneity of marine-continental transitional shale, the matrix grid is layered, and physical property parameters and corresponding apparent permeability models for different rocks are introduced. The fracture surface is dimensionality-reduced based on artificial fracture parameters, and the crossflow coefficient is used to characterize the pressure exchange between grids. Further calculations of flow exchange between different grids are performed, and the productivity of each lithology can be obtained through stratigraphic tracing. The combination of a multiple continuous medium model and an embedded discrete fracture model overcomes the shortcomings of their respective models, better reflecting the widely distributed microfractures, large-scale artificial fractures, and heterogeneous stratigraphic characteristics of transitional shale gas reservoirs. In addition to evaluating the productivity of marine-continental transitional shale gas, the method proposed in this invention can also be extended to the productivity calculation of unconventional oil and gas reservoirs, demonstrating significant application value.

The present application belongs to the technical field of petroleum engineering, and discloses a multi-factor synergistic shale gas apparent permeability prediction method coupled with molecular dynamics and a related device. Initial parameters are obtained, and the initial parameters are used to calculate the effective pore radius under the action of stress, the pore radius change amount caused by the pressure sensitivity effect, the gas coverage, the equivalent pore radius occupied by the adsorbed gas molecules, and the pore radius change amount considering the temperature influence. The equivalent pore radius, the Knudsen number considering the pressure sensitivity effect and the temperature influence on the shale gas adsorption process are considered, and finally the apparent permeability considering the pressure sensitivity effect, the temperature influence on the shale gas adsorption process, and the movement characteristics of the gas molecules in the nanometer pore is obtained. The present application can more comprehensively consider the pressure sensitivity effect, the temperature change, and the movement characteristics of the gas molecules in the nanometer pore, and can more accurately realize the prediction of the permeability.

The application discloses a kind of deep unconventional compact reservoir permeability effective stress coefficient precision determination and multi-mechanism decoupling method.The present application relates to the technical field of unconventional compact natural gas development, and the method comprises the following steps: non-adsorptive and adsorptive gas is respectively introduced into rock sample, and the first and second apparent permeability is obtained under different confining pressure and pore pressure;By permeability continuous evolution surface modeling, the permeability rebound boundary is identified, and the pressure space is divided into the main control area of slippage effect and the main control area of effective stress;The effective stress coefficient and the first slippage factor are inverted in the main control area of slippage, and the stress sensitivity coefficient of adsorptive gas is inverted in the main control area of effective stress, and the inherent permeability of adsorptive gas is calculated according to the first slippage factor and the second apparent permeability;Based on the inherent permeability model, the internal expansion coefficient is inverted;Finally, the contribution proportion of slippage effect, stress effect and adsorption deformation effect is calculated, so as to divide the main control stage of reservoir extraction period.

The invention relates to an anisotropic shale matrix apparent permeability calculation method, which comprises the following steps: directionally sampling a rock core sample in parallel bedding / vertical bedding directions, and obtaining anisotropic characteristic parameters such as TOC, aperture, surface diffusion coefficient, stress sensitivity coefficient and the like through experiments; according to the method, high-pressure mercury injection and nuclear magnetic resonance experiments are combined to represent multi-scale pore distribution and connectivity, an atomic force microscope is adopted to measure pore surface roughness, and a cone roughness element is taken as a physical model to represent roughness fractal dimension; on the basis of a three-dimensional fractal theory, factors such as multi-scale pore size distribution, connectivity, roughness, a water film, stress sensitivity and a real gas effect are integrated, transmission mechanisms such as viscous flow, Knudsen diffusion, surface diffusion and a desorption effect are coupled, and the anisotropic multi-scale micro-nano pore mass transfer model of the shale is established. Compared with a prediction model in the prior art, the anisotropic shale matrix apparent permeability calculation method provided by the invention is higher in accuracy.

The invention discloses a shale gas reservoir apparent permeability calculation method based on a fuzzy theory, and belongs to the field of petroleum and natural gas engineering, and the shale gas reservoir apparent permeability calculation method comprises the following steps: S1, establishing a concentration cloud model of free gas and adsorbed gas, S2, establishing a flux model of a shale gas reservoir, S3, calculating the membership degree of each flow mechanism, and S4, deducing the apparent permeability. The fuzzy theory and the multi-mechanism flow model are creatively fused, the limitation of a traditional calculation method under the complex reservoir condition is effectively broken through, the accuracy and reliability of apparent permeability calculation are improved, the adaptability of the method to different geological conditions is enhanced, and the method has good application prospects. According to the method, more scientific theoretical support and technical guarantee are provided for efficient exploration and development of shale gas reservoirs, meanwhile, fuzzy features of multi-mechanism flow are accurately described, the calculation precision is improved, different geological conditions are dynamically adapted, the applicability of the method is enhanced, the multi-mechanism contribution proportion is quantified, and a basis is provided for optimization of a development scheme.

The invention discloses an in-vitro permeability evaluation method of an insoluble compound and application of poloxamer 407 in in-vitro permeability evaluation of the insoluble compound. The evaluation method comprises the following steps: S1, carrying out correlation analysis on the oral absorption percentage of a known medicine in a human body and the apparent permeability coefficient of the known medicine in an in-vitro permeability evaluation system containing poloxamer 407, and establishing an in-vitro permeability evaluation standard; s2, adding poloxamer 407 into the in-vitro permeability evaluation system containing the indissolvable compound, and determining the apparent permeability coefficient of the indissolvable compound; s3, comparing the apparent permeability coefficient measured in the step S2 with the in-vitro permeability evaluation standard established in the step S1, and evaluating the permeability of the indissolvable compound. According to the in-vitro permeability evaluation method for the indissolvable compound, the absorption and pharmacokinetic characteristics of the indissolvable compound in a human body can be more accurately predicted, important support is provided for drug screening and development, and the efficiency and success rate of new drug research and development are improved.

The invention is suitable for the technical field of hydraulic engineering, and provides an earth and rockfill dam seepage safety state evaluation method, terminal equipment and a storage medium, and the earth and rockfill dam seepage safety state evaluation method comprises the following steps: constructing an earth and rockfill dam seepage-proofing body standardization model; based on the earth and rockfill dam anti-seepage body standardized model, calculating the theoretical seepage flow of the earth and rockfill dam anti-seepage body; the actual seepage flow of the earth and rockfill dam is obtained through measurement, the apparent permeability coefficient is calculated, and the apparent permeability coefficient is the ratio of the actual seepage flow to the theoretical seepage capacity; calculating the defect coefficient of the anti-seepage system, wherein the defect coefficient of the anti-seepage system is the ratio of the apparent permeability coefficient to the permeability coefficient test value; and according to the numerical value of the defect coefficient of the anti-seepage system, evaluating the seepage safety state of the earth and rockfill dam. The seepage safety state of the earth and rockfill dam can be rapidly evaluated through the defect coefficient of the seepage-proofing system, so that the construction quality of a dam project is inspected, and seepage damage outburst can be rapidly early warned and handled.

This invention relates to the field of oilfield development technology, specifically to a method, apparatus, and electronic equipment for inverting the apparent permeability of shale reservoirs based on gradient-enhanced PINN. The method includes the following steps: S1, establishing the basic differential equation of the target shale reservoir, and constructing various heterogeneous models of shale reservoir permeability based on the basic differential equation; S2, obtaining the basic parameters required for the basic differential equation and generating datasets for each of the various heterogeneous models through numerical simulation; S3, constructing an inversion model based on a neural network, inputting the datasets into the inversion model, and comparing the parameters inverted from each of the various heterogeneous models with the actual parameter values. If the relative error between the two does not exceed a set threshold, the inversion model is considered valid; otherwise, it is invalid. The technical solution of this invention can be applied to the prediction of apparent permeability of shale reservoirs, has stronger information integration capabilities, and high prediction accuracy.

The invention discloses a controllable source electromagnetic apparent parameter extraction method and system based on an optimization algorithm. The method comprises the following steps: acquiring a first type of apparent parameter of controllable source electromagnetic highest frequency; wherein the first apparent parameter is apparent resistivity or apparent permeability, and the other apparent parameter is a second apparent parameter; fixing a first apparent parameter of the highest frequency, and calculating a second apparent parameter of the highest frequency by adopting a uniform half-space formula considering the influence of underground resistivity and magnetic conductivity and an optimization algorithm based on measuring each electromagnetic field component of the highest frequency as an observed quantity; according to the sequence of frequencies from high to low, taking the two apparent parameters of the previous frequency point as the initial value of the next frequency point in sequence, taking each electromagnetic field component measured at the next frequency point as the observed quantity, and adopting a uniform half-space formula considering the influence of underground resistivity and magnetic conductivity and an optimization algorithm to calculate the electromagnetic field component of the next frequency point; and calculating two visual parameters of the next frequency point. According to the method, the apparent resistivity and apparent permeability parameters can be efficiently and accurately extracted.

The invention belongs to the technical field of geophysical logging and oil-gas field development, and discloses a deep coal reservoir in-situ apparent permeability calculation method applied to nuclear magnetic logging. The method comprises the following steps: acquiring a deep coal reservoir in-situ nuclear magnetic resonance spectrum; calculating the accumulated signal amplitude of the spectrum; fitting the relationship under a double logarithmic coordinate system, and solving fractal dimensions representing the heterogeneity of the pore structure; the fractal absolute permeability is calculated according to the Lisdarcy law; and finally, in combination with a Klinkenberg equation, establishing a complete model for predicting the apparent permeability under any pore pressure. The permeability result calculated through the method is highly consistent with the in-situ real flow capacity, if the relative error in the embodiment is only 1.34%, the technical problem that an existing model loses the actual guiding significance for productivity prediction due to result distortion is solved.

The application is suitable for the technical field of water conservancy projects, and provides an evaluation method for the seepage safety state of an earth-rock dam, a terminal device and a storage medium. The evaluation method for the seepage safety state of the earth-rock dam comprises the following steps: constructing an earth-rock dam anti-seepage body standardization model; calculating the theoretical seepage flow of the earth-rock dam anti-seepage body based on the earth-rock dam anti-seepage body standardization model; measuring the actual seepage flow of the earth-rock dam to calculate an apparent permeability coefficient, the apparent permeability coefficient being the ratio of the actual seepage flow to the theoretical seepage flow; calculating an anti-seepage system defect coefficient, the anti-seepage system defect coefficient being the ratio of the apparent permeability coefficient to a permeability coefficient test value; and evaluating the seepage safety state of the earth-rock dam according to the numerical value of the anti-seepage system defect coefficient. The anti-seepage system defect coefficient can be used to quickly evaluate the seepage safety state of the earth-rock dam, so as to test the construction quality of the dam project, and to make a quick warning and disposal for seepage damage and breach.

The invention discloses a multi-stage fractured horizontal well three-area coupling productivity calculation method and related equipment, and relates to the technical field of unconventional natural gas exploration and development, and the method comprises the steps: obtaining the apparent permeability of a gas reservoir non-transformation area, the equivalent permeability of a micro-fracture network of a gas reservoir fractured transformation area, and a hydraulic fracture area pressure drop matrix; on the basis of the apparent permeability, the infinite space point sink function and the box type closed space point sink function, a non-transformation area pressure drop matrix is constructed; constructing a transformation area pressure drop matrix based on the equivalent permeability and a box type closed space point convergence function; and a total pressure drop matrix is constructed based on the hydraulic fracture area pressure drop matrix, the non-transformation area pressure drop matrix and the transformation area pressure drop matrix, a yield matrix equation is solved according to the total pressure drop matrix and a matrix iteration method, and the horizontal well yield is obtained.