The invention relates to the technical field of chemical plant safety, in particular to a chemical plant online safety diagnosis and accident disposal guidance method and system, and the method comprises the following steps: A), building and storing a monitoring table and a plan, and entering a step B if an alarm is given; b) if the trigger condition is not satisfied, closing the alarm, otherwise,triggering the plan and the update table to update the corresponding alarm condition, and displaying the accident handling content; c) reading the monitoring data of the chemical plant in a period T,if the monitoring data meets an alarm condition, giving an alarm, improving the accident level by one level, and displaying the accident grading disposal content of the corresponding level; and D) ifthe monitoring data meets the release condition, releasing the alarm, and returning to the step A. The invention has the substantive effects of assisting the disposal of the accident, displaying thesub-region state of the chemical plant for the operator on duty, making a personnel evacuation scheme in a targeted manner, reducing the accident loss, and improving the personnel safety in the accident.