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Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof

A technology of implants and magnesium alloys, applied in prosthetics, medical science, coatings, etc., to achieve the effects of promoting tissue healing, inhibiting bone resorption, and promoting osteogenesis

Inactive Publication Date: 2012-07-18
浙江海圣医疗器械股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are no literatures and patents at home and abroad to propose that Mg-Sr alloys be used as biomedical materials.

Method used

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  • Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof
  • Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof
  • Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0059] The test raw materials are pure Mg (99.95wt.%) and Mg-Sr master alloy, prepared according to Mg-xSr (nominal composition Sr: 1%-4%), in CO 2 +SF 6 Melting under the protection of atmosphere. First melt the pure magnesium ingot in a resistance furnace, and when the temperature rises to 750°C, add the Mg-Sr intermediate alloy. 2 +SF 6 Gravity casting is performed by pouring under the protection of mixed gas, and the mold is preheated to 200°C. Adopt the as-cast Mg-xSr alloy microstructure that the present invention obtains as figure 1 , figure 2 , image 3 , Figure 4 shown.

Embodiment 2

[0061] The alloy smelting process is the same as in Example 1. The Mg-xSr alloy ingot is processed into a 6mm thick plate, sanded until there are no obvious defects, and kept at 400°C for 3 hours before rolling. Furnace for 10 minutes, and finally rolled to a 1.2mm thick sheet. The as-rolled Mg-xSr alloy is processed into a tensile standard sample, and the tensile test at room temperature is carried out at a tensile speed of 1mm / min. The XRD spectrum of the as-rolled Mg-xSr alloy that adopts the present invention to obtain is as Figure 5 As shown, the room temperature tensile properties are as Figure 6 shown.

Embodiment 3

[0063] The as-rolled Mg-xSr alloy in embodiment 2 was prepared by wire cutting to 10×10×2mm 3 Sample piece, sanded with water sandpaper to 2000 # Afterwards, wash with acetone, absolute ethanol, and ultrasonic for 5 minutes each, dry, soak in Hank's simulated body fluid, and keep warm at 37°C. The samples were taken out after soaking for different time by X-ray diffraction (XRD) and scanning electron microscope (SEM) to detect the corrosion products on the alloy surface. The SEM morphology and XRD pattern of the alloy soaked for 10 days are as follows: Figure 7 , Figure 8 , Figure 9 , Figure 10 , Figure 11 , Figure 12 .

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Abstract

The invention relates to a medical degradable and absorbable Mg-Sr system magnesium alloy implant and a preparation method thereof. The medical implant is made of Mg-Sr system alloy, and the Mg-Sr system alloy comprises the following elements in percentage by weight: 0 to 5 percent of strontium (except for 0 percent), a small amount of trace elements, namely one or more of manganese, zirconium, stannum, rare earth and yttrium and the balance of magnesium, wherein the total content of the trace elements is less than 3 percent. In-vivo and in-vitro experiments prove that the Mg-Sr system magnesium alloy implant does not have toxicity, has high histocompatibility, and is a reliable biological medical implant material.

Description

technical field [0001] The invention relates to a degradable and absorbable Mg-Sr alloy medical implant and a preparation method thereof. The degradable absorbable Mg-Sr alloy design is non-toxic and has good tissue compatibility, adjustable mechanical properties and degradation speed, and is suitable as a degradable orthopedic implant device. Background technique [0002] At present, biodegradable materials for medical use are mainly degradable polymer materials and degradable ceramic materials. Degradable polymer materials include polyglycolic acid (PGA), polylactic acid (PLA), polylactone (PCL) and their copolymers. , natural polysaccharide materials (cellulose, chitin) and natural protein materials (collagen, fibrin), etc.; widely used degradable ceramics include hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate and phosphoric acid Oxytetracalcium. Although degradable polymer materials can be completely absorbed by the human body, they have low strength an...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/32A61L27/34C22C23/00C22C23/06C22C1/08C22F1/06
Inventor 郑玉峰顾雪楠王利明黄海生李坚
Owner 浙江海圣医疗器械股份有限公司
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