Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof

A technology of implants and magnesium alloys, applied in prosthetics, medical science, coatings, etc., to achieve the effects of promoting tissue healing, inhibiting bone resorption, and promoting osteogenesis

Inactive Publication Date: 2012-07-18
浙江海圣医疗器械股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] At present, there are no literatures and patents at home and

Method used

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  • Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof
  • Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof
  • Medical degradable and absorbable Mg-Sr system magnesium alloy implant and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0058] Example 1

[0059] The raw materials used in the test are pure Mg (99.95wt.%) and Mg-Sr master alloy, prepared according to Mg-xSr (nominal composition Sr: 1%-4%). 2 +SF 6 Smelting under atmosphere protection. First melt the pure magnesium ingot in a resistance furnace, add Mg-Sr master alloy when the temperature rises to 750℃, wait until the test material is fully melted and kept for 30min, 720℃ in CO 2 +SF 6 Gravity casting is performed by pouring under the protection of mixed gas, and the mold is preheated to 200°C. The as-cast Mg-xSr alloy microstructure obtained by the present invention is as figure 1 , figure 2 , image 3 , Figure 4 Shown.

Example Embodiment

[0060] Example 2

[0061] The alloy smelting process is the same as that in Example 1. The Mg-xSr alloy ingot is processed into a 6mm thick plate, sanded with sandpaper until there is no obvious defect, and is kept at 400°C for 3 hours before rolling. Each pass has a reduction of 0.2mm, and each pass Furnace for 10 minutes, and finally rolled to 1.2mm thick sheet. The rolled Mg-xSr alloy was processed into a tensile standard sample, and the tensile test was carried out at room temperature with a tensile speed of 1 mm / min. The XRD pattern of the rolled Mg-xSr alloy obtained by the present invention is as follows Figure 5 As shown, the room temperature tensile properties are as Image 6 Shown.

Example Embodiment

[0062] Example 3

[0063] Wire the rolled Mg-xSr alloy in Example 2 to prepare 10×10×2mm 3 Sample piece, polished with water sandpaper to 2000 # After washing with acetone, absolute ethanol, and ultrasonic for 5 minutes, after drying, soak in Hank’s simulated body fluid and keep at 37°C. Samples were taken out after soaking for different time, X-ray diffraction (XRD) and scanning electron microscope (SEM) were used to detect corrosion products on the alloy surface. The SEM morphology and XRD pattern of the alloy after soaking for 10 days are as follows Figure 7 , Figure 8 , Picture 9 , Picture 10 , Picture 11 , Picture 12 .

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Abstract

The invention relates to a medical degradable and absorbable Mg-Sr system magnesium alloy implant and a preparation method thereof. The medical implant is made of Mg-Sr system alloy, and the Mg-Sr system alloy comprises the following elements in percentage by weight: 0 to 5 percent of strontium (except for 0 percent), a small amount of trace elements, namely one or more of manganese, zirconium, stannum, rare earth and yttrium and the balance of magnesium, wherein the total content of the trace elements is less than 3 percent. In-vivo and in-vitro experiments prove that the Mg-Sr system magnesium alloy implant does not have toxicity, has high histocompatibility, and is a reliable biological medical implant material.

Description

technical field [0001] The invention relates to a degradable and absorbable Mg-Sr alloy medical implant and a preparation method thereof. The degradable absorbable Mg-Sr alloy design is non-toxic and has good tissue compatibility, adjustable mechanical properties and degradation speed, and is suitable as a degradable orthopedic implant device. Background technique [0002] At present, biodegradable materials for medical use are mainly degradable polymer materials and degradable ceramic materials. Degradable polymer materials include polyglycolic acid (PGA), polylactic acid (PLA), polylactone (PCL) and their copolymers. , natural polysaccharide materials (cellulose, chitin) and natural protein materials (collagen, fibrin), etc.; widely used degradable ceramics include hydroxyapatite, α-tricalcium phosphate, β-tricalcium phosphate and phosphoric acid Oxytetracalcium. Although degradable polymer materials can be completely absorbed by the human body, they have low strength an...

Claims

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Application Information

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IPC IPC(8): A61L27/04A61L27/32A61L27/34C22C23/00C22C23/06C22C1/08C22F1/06
Inventor 郑玉峰顾雪楠王利明黄海生李坚
Owner 浙江海圣医疗器械股份有限公司
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