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Modification method for titanium surface with osteogenic performance and antibacterial performance

A surface modification and performance technology, applied in the direction of prosthesis, vacuum evaporation plating, coating, etc., can solve the problem of not being able to achieve both osteogenesis and antibacterial, and achieve easy popularization and application, good controllability, and adhesion and growth-promoting effect

Active Publication Date: 2013-04-03
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention is based on the fact that free silver nanoparticles are easily phagocytized by normal cells and cause biological toxicity, and the single calcium injection process promotes the adhesion, differentiation, proliferation and other behaviors of osteoblasts, but it also promotes the adhesion of bacteria on the surface of the material. Adhesion, proliferation, can not achieve the problem of both osteogenesis and antibacterial properties, proposed the use of plasma immersion ion implantation technology, and simultaneously implanted silver and calcium into the surface of the substrate, and proposed a preparation method for the surface with both osteogenic and antibacterial properties

Method used

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  • Modification method for titanium surface with osteogenic performance and antibacterial performance
  • Modification method for titanium surface with osteogenic performance and antibacterial performance
  • Modification method for titanium surface with osteogenic performance and antibacterial performance

Examples

Experimental program
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Effect test

Embodiment 1

[0042] (a) Use medical pure titanium as the base material, degrease the surface with acetone and install it in the furnace. Use a pulsed arc source, use pure silver and pure calcium as the cathode, and use an ordinary pencil (such as 2B) to coat a complete layer of calcium cathode. The carbon covering layer has a thickness greater than 200 nanometers, and then undergoes co-implantation of silver and calcium plasma immersion ions. Ion implantation adopts an ion implanter with two pulsed arc sources, and the two pulsed arc sources are controlled in linkage. The ion implantation process parameters are: the temperature of the vacuum chamber is 50-60°C, the vacuum degree is 3×E-3-4×E-3Pa, the implantation voltage is 30-40kV, the pulse width is 300-450μs, and the frequency is 5-7Hz. The processing time is 1.0h;

[0043] (b) X-ray photoelectron spectroscopy analysis (the instrument used is PHI 5802 of PE-PHI Company of the United States), shows that after ion implantation, silver an...

Embodiment 2

[0047] (a) Use medical pure titanium as the base material, degrease the surface with acetone and install it in the furnace. Use a pulsed arc source, use pure silver and pure calcium as the cathode, and use an ordinary pencil (such as 2B) to coat a complete layer of calcium cathode. The carbon covering layer has a thickness greater than 200 nanometers, and then undergoes co-implantation of silver and calcium plasma immersion ions. Ion implantation adopts an ion implanter with two pulsed arc sources, and the two pulsed arc sources are controlled in linkage. The ion implantation process parameters are: the temperature of the vacuum chamber is 20-40°C, the vacuum degree is 3×E-3-4×E-3Pa, the implantation voltage is 15-25kV, the pulse width is 500-600μs, and the frequency is 7-9Hz. The processing time is 0.5h;

[0048] (b) Scanning electron microscope observation shows that after ion implantation treatment, silver nanoparticles are formed on the surface of the material ( Figure ...

Embodiment 3

[0052] (a) Use medical pure titanium as the base material, degrease the surface with acetone and install it in the furnace. Use a pulsed arc source, use pure silver and pure calcium as the cathode, and use an ordinary pencil (such as 2B) to coat a complete layer of calcium cathode. The carbon covering layer has a thickness greater than 200 nanometers, and then undergoes co-implantation of silver and calcium plasma immersion ions. Ion implantation adopts an ion implanter with two pulsed arc sources, and the two pulsed arc sources are controlled in linkage. The ion implantation process parameters are: the temperature of the vacuum chamber is 30-50°C, the vacuum degree is 3×E-3-4×E-3Pa, the implantation voltage is 25-30kV, the pulse width is 400-550μs, and the frequency is 6-8Hz. The processing time is 2.0h;

[0053] (b) X-ray photoelectron spectrum analysis (the instrument used is PHI 5802 of PE-PHI Company of the United States), which shows that after ion implantation, silver ...

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Abstract

The invention relates to a modification method for a titanium surface with osteogenic performance and antibacterial performance. The modification method adopts a plasma-immersion ion implantation treatment process to co-implant silver ion and calcium ion to the surface of a titanium base material, wherein the co-implantation simultaneously arouse two cathode impulse arc sources, which respectively adopt pure silver and pure calcium as a cathode, to carry out plasma-immersion ion implantation treatment process. The silver-calcium co-implantation method provided by the invention can be used for improving the osteogenic performance and antibacterial performance of the surface (for example an artificial bone, an artificial joint and a dental implant) which can be implanted to medical equipment. The prepared modified material has a remarkable inhibitory effect to the escherichia coli and staphylococcus aureus, and a remarkable promotion to adhesion and proliferation of relevant osteoblast (BMSCs, MG63 cells).

Description

technical field [0001] The invention relates to a method for preparing an osteogenic and antibacterial surface on the surface of a medical device, more precisely, it relates to a silver and calcium co-implantation process that can be used on the surface of artificial bones, artificial joints and dental implants. A surface modification method to endow it with both osteogenic and antimicrobial properties. The invention belongs to the field of surface modification of medical materials. Background technique [0002] In recent years, with the continuous improvement and development of material surface coating preparation theory and technology, the surface modification technology of Ti implants has developed rapidly, which further improves the biocompatibility of Ti implants. However, as mentioned above, long-term clinical follow-up and research have found that there are two main reasons for implant failure at this stage [Biomacromolecules, 2009, 10: 1603-1611; Tissue Engineering:...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/48A61L27/30A61L27/54
Inventor 曹辉亮刘宣勇
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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