A method for constructing inorganic microflower chimeric metal-organic composite nanocluster modified functional layer on the surface of biodegradable zinc

A technology of nano-clusters and micro-flowers, applied in the field of surface modification of biomedical materials, can solve the problem that it is difficult to take into account corrosion degradation control and biological functionality at the same time, and achieves the advantages of promoting adhesion and proliferation, enhancing hydrophilicity and improving biological activity. Effect

Active Publication Date: 2021-05-18
SOUTHWEST JIAOTONG UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a method for constructing inorganic micron flower chimeric metal-organic coatings on the surface of biodegradable zinc to solve the problem that it is difficult to take into account both corrosion degradation control and biological functionality in the modification of a single coating in the prior art. Method for modifying functional layer by composite nanocluster

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for constructing inorganic microflower chimeric metal-organic composite nanocluster modified functional layer on the surface of biodegradable zinc
  • A method for constructing inorganic microflower chimeric metal-organic composite nanocluster modified functional layer on the surface of biodegradable zinc
  • A method for constructing inorganic microflower chimeric metal-organic composite nanocluster modified functional layer on the surface of biodegradable zinc

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A preferred embodiment of the present invention provides a method for constructing an inorganic micron flower chimeric metal-organic composite nano-cluster modified functional layer on the surface of biodegradable zinc. The specific steps are as follows:

[0048] a. Preparation of metal-organic composite nanoclusters: 20g / L Zn(NO 3 ) 2 ˙6H 2 O and 2g / L ZA solution, adjust the pH to 4 with NaOH solution, fully stir the reaction in a water bath at 40°C for 12h, filter to obtain a white solid, wash with deionized water and absolute ethanol three times in turn, and then in 60°C Dry for 24h. Prepare a 2 g / L HEDP solution with pH=4, and ultrasonically disperse the dry white solid obtained above into this solution to prepare a 1.2 g / L metal-organic composite nanocluster suspension for later use.

[0049] b. Polish the pure zinc to 2000# with sandpaper, wash it with absolute ethanol three times under ultrasonic conditions, each time for 5 minutes, and dry it for later use. ...

Embodiment 2

[0054] A preferred embodiment of the present invention provides a method for constructing an inorganic micron flower chimeric metal-organic composite nano-cluster modified functional layer on the surface of biodegradable zinc. The specific steps are as follows:

[0055] a. Preparation of metal-organic composite nanoclusters: 18g / L Zn(NO 3 ) 2 ˙6H 2 O and 1.5g / L ZA solution, using NaOH solution to adjust the pH to 4, fully stirred and reacted in a water bath at 40°C for 12h, filtered to obtain a white solid, washed with deionized water and absolute ethanol for 3 times, and then heated at 60°C Dry for 24 hours. Prepare a 2 g / L HEDP solution with pH=4, and ultrasonically disperse the dry white solid obtained above into this solution to prepare a 1.3 g / L metal-organic composite nanocluster suspension for later use.

[0056] b. Polish the pure zinc to 2000# with sandpaper, wash it with absolute ethanol three times under ultrasonic conditions, each time for 5 minutes, and dry it ...

Embodiment 3

[0060] A preferred embodiment of the present invention provides a method for constructing an inorganic micron flower chimeric metal-organic composite nano-cluster modified functional layer on the surface of biodegradable zinc. The specific steps are as follows:

[0061] a. Preparation of metal-organic composite nanoclusters: 23g / L Zn(NO 3 ) 2 ˙6H 2 O and 2.5g / L ZA solution, adjust the pH to 4 with NaOH solution, fully stir the reaction in a 40°C water bath for 12h, filter to obtain a white solid, wash with deionized water and absolute ethanol three times in turn, and then in 60°C Dry for 24 hours. Prepare a 2 g / L HEDP solution with pH=4, and ultrasonically disperse the dry white solid obtained above into this solution to prepare a 1.1 g / L metal-organic composite nanocluster suspension for later use.

[0062] b. Polish the pure zinc to 2000# with sandpaper, wash it with absolute ethanol three times under ultrasonic conditions, each time for 5 minutes, and dry it for later us...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a method for constructing a modified functional layer of inorganic micron flowers embedded metal-organic composite nano-clusters on the surface of biodegradable zinc. Preparation of inorganic microflower chimeric metal-organic composite nanocluster modified functional coating on zinc metal surface. On the one hand, the present invention constructs the modified functional layer of inorganic microflower chimeric metal-organic composite nano-clusters, which not only delays the degradation rate of metals, but also promotes the activity of osteoblasts. On the other hand, the present invention provides a new method for embedding zinc-organic composite nano-clusters on the surface of the coating, that is, using chemical coordination to drive the binding of the binder to the active sites on the substrate and the surface of the particles to achieve particle fixed load.

Description

technical field [0001] The invention belongs to the technical field of surface modification of biomedical materials, and in particular relates to a method for constructing an inorganic micron flower chimeric metal-organic composite nano-cluster modified functional layer on the surface of biodegradable zinc. Background technique [0002] As the third-generation degradable metal, zinc has attracted wide attention because of its moderate corrosion rate and zinc is an important trace element in the human body. The biodegradable zinc alloy will neither corrode too slowly like stainless steel nor too fast like magnesium alloy in the human body, so it can be used as a medical degradable metal material with better effect to solve the problem of iron-based and magnesium-based medical problems. The problems faced by degrading metal materials. In addition, while having a controllable corrosion rate, zinc alloys also have good biocompatibility. [0003] However, degradable zinc-based ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/22C23C22/17A61L31/02A61L31/08A61L31/14A61L31/16
CPCA61L31/022A61L31/08A61L31/14A61L31/148A61L31/16A61L2300/112A61L2300/412A61L2300/606A61L2400/18A61L2420/04C23C22/17C23C22/22
Inventor 万国江曾培杰钱军余张文泰莫小山沈岗黄楠
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap