Method for preparing titanium implant and obtained titanium implant

An implant and matrix technology, applied in the field of medical materials, can solve the problems of unfavorable cell adhesion, proliferation, differentiation and functional expression, compatibility and limited binding ability, etc., to increase compatibility and binding ability, and improve osseointegration ability Effect

Active Publication Date: 2014-04-23
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The present invention aims at the technical problems in the prior art that the titanium implant with a micron structure on the surface has limited compatibility and bonding ability with bone, which is

Method used

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  • Method for preparing titanium implant and obtained titanium implant
  • Method for preparing titanium implant and obtained titanium implant
  • Method for preparing titanium implant and obtained titanium implant

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Step A) Process the implant matrix with pure titanium, polish the surface of the implant matrix, then ultrasonically clean with acetone, absolute ethanol and deionized water for 30 minutes, and dry naturally;

[0023] Step B) Put the implant matrix into the prepared mixed acid solution (HNO 3 : HF volume ratio of 5:1) for 10 minutes of ultrasonic treatment, the outer surface of the implant matrix was corroded into a structural layer with micron roughness, and then ultrasonically cleaned with absolute ethanol and deionized water for 10 minutes, and dried naturally, see figure 1 shown;

[0024] Step C) Using constant voltage direct current anodizing technology to in-situ oxidize the microstructure surface of the implant matrix into a titanium oxide nanotube film, the specific process parameters are: the implant matrix is ​​the anode, the graphite electrode is the cathode, and the electrolyte composition is 1.0 % hydrofluoric acid solution, the working voltage is 20V, the...

Embodiment 2

[0026] Step A) Process the implant matrix with pure titanium, polish the surface of the implant matrix, then ultrasonically clean with acetone, absolute ethanol and deionized water for 30 minutes, and dry naturally;

[0027] Step B) Put the implant matrix into the configured diluted concentration of 40% mixed acid solution (HNO 3 : HF volume ratio is 5:1) for 5 minutes of ultrasonic cleaning, followed by ultrasonic cleaning with absolute ethanol and deionized water for 10 minutes, and natural drying;

[0028] Step C) Using constant voltage direct current anodizing technology to in-situ oxidize the microstructure surface of the implant matrix into a titanium oxide nanotube film, the process parameters of the matrix are: the implant matrix is ​​the anode, the platinum sheet electrode is the cathode, and the electrolyte is composed of 0.5% hydrofluoric acid solution, the working voltage is 25V, the oxidation time is 1.5 hours, and the reaction temperature is room temperature; the...

Embodiment 3

[0030] Step A) Process the implant matrix with pure titanium, polish the surface of the implant matrix, then ultrasonically clean with acetone, absolute ethanol and deionized water for 30 minutes, and dry naturally;

[0031] Step B) Perform mechanical sandblasting on the implant matrix, and grind the outer surface of the implant matrix into a structural layer with micron roughness, see image 3 shown;

[0032] Step C) Using constant voltage direct current anodic oxidation technology, in-situ oxidation of the microstructure surface of the implant matrix into a titanium oxide nanotube film, the specific process parameters are: the implant matrix is ​​the anode, the platinum electrode is the cathode, and the electrolyte is composed of 0.7% hydrofluoric acid solution, the working voltage is 20V, the oxidation time is 1 hour, and the reaction temperature is room temperature; then ultrasonic cleaning with deionized water for 5 minutes and natural drying to obtain a bionic titanium i...

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Abstract

The invention discloses a method for preparing a biomimetic titanium implant with a micro-nano composite structure on a surface and the obtained titanium implant. The method comprises the following steps: A) processing pure titanium or a titanium alloy into an implant substrate, performing surface polishing, performing ultrasonic washing by using acetone, absolute ethanol and deionized water in sequence, and drying; B) processing the surface of the substrate into a micro-nano structure by adopting a mixed acid ultrasonic treatment mode or a mechanical sandblasting treatment mode; C) oxidizing the surface of the micro-nano structure into a titanium oxide nanotube film in situ by adopting a constant-voltage direct-current anodic oxidation technology, so that the biomimetic titanium implant with the micro-nano composite structure on the surface is obtained. The biomimetic titanium implant disclosed by the invention can effectively increase the compatibility and the bonding capacity with bones, and is also favorable to the adhesion, the proliferation, the differentiation and the functional expression of cells, so that the osseointegration capacity and the operation success rate of the implant are improved.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a method for preparing a bionic titanium implant with a micro-nano composite structure on the surface and the obtained bionic titanium implant with a micro-nano composite structure on the surface. Background technique [0002] Titanium and titanium alloys have excellent biocompatibility, corrosion resistance and mechanical properties. As a medical material, they are widely used in the clinical treatment of repairing hard tissue damage and loss. However, titanium and titanium alloys are biologically inert materials, which cannot induce new bone growth after implantation in the body, are weakly combined with bone tissue, and take a long time to heal. [0003] Implant surface modification is an effective method to improve its surface bioactivity and osseointegration ability without changing the specific properties of the matrix. Studies have shown that increas...

Claims

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Application Information

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IPC IPC(8): A61L27/06A61L27/50C25D11/26
Inventor 刘宣勇钱仕
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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