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Method for preparing antibacterial coating on surface of titanium implant

A technology of titanium implants and antibacterial coatings, applied in coatings, metal material coating processes, prostheses, etc., can solve problems such as complex preparation techniques, and achieve the effects of simple methods, good antibacterial properties and biocompatibility

Active Publication Date: 2016-06-22
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Zhang Yumei et al. prepared nano-titanium tubes on the titanium surface first, and then attached nano-silver particles to the nano-titanium tubes to enhance the antibacterial properties of the titanium surface. However, the preparation process of this method is complicated, and after the prepared nano-titanium tubes are dried, due to capillary action, Solutions containing silver ions have difficulty getting into nanotubes

Method used

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  • Method for preparing antibacterial coating on surface of titanium implant
  • Method for preparing antibacterial coating on surface of titanium implant
  • Method for preparing antibacterial coating on surface of titanium implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Prepare antibacterial coating on titanium surface according to the preparation steps of titanium surface sterilization and antibacterial coating, the molecular weight of polyethyleneimine is 10000 in step 2; the molecular weight of uric acid is 100000 in step 3, the viscosity of chitosan<200mpa .s, the concentration of chitosan and uric acid aqueous solution is 1mg / L; the number of multilayer film layers in step 4 is 20 layers. The concentration of sodium chloride solution in step 5 is 0.1 mol / liter; the concentration of silver nitrate and ascorbic acid in step 6 is 0.1 mol / liter, and the immersion time is 0.5 hours. The bacteriostatic coating prepared by this method has a bacteriostatic rate of 83% against Streptococcus mutans.

Embodiment 2

[0041] Prepare antibacterial coating on titanium surface according to the preparation steps of titanium surface sterilization and antibacterial coating, the molecular weight of polyethyleneimine is 10000 in step 2; 400mpa.s, chitosan and mass acid aqueous solution concentration are 2mg / L; Multilayer film number of layers is 20 layers in step 4; Sodium chloride solution concentration is 0.2 mol / liter in step 5; Silver nitrate and ascorbic acid in step 6 The concentrations are all 0.2 mol / liter, and the immersion time is all 1 hour. The bacteriostatic coating prepared by this method has a bacteriostatic rate of 87% against Streptococcus mutans.

Embodiment 3

[0043]Prepare antibacterial coating on titanium surface according to the preparation steps of titanium surface sterilization and antibacterial coating, the molecular weight of polyethyleneimine is 70000 in step 2; 400mpa.s, the concentration of chitosan and uric acid aqueous solution is 4mg / L; the number of layers of multilayer film in step 4 is 40 layers. The sodium chloride solution concentration is 0.3 mol / liter among the step 5; The concentration of the silver nitrate solution is 0.2 mol / liter among the step 6, and the immersion time is 1 hour, and the concentration of ascorbic acid is 0.4 mol / liter, and the immersion time is 0.5 hour. The bacteriostatic coating prepared by this method has a bacteriostatic rate of 91% against Streptococcus mutans.

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Abstract

The invention provides a method for preparing an antibacterial coating on the surface of a titanium implant. A silver-loaded polyelectrolyte multilayer film is prepared on the titanium surface with a layer-layer self-assembly method, so that the titanium surface has good biocompatibility and antibacterial performance. The method is simple and particularly suitable for implants in complex shapes; the surface coating adopts natural polymers with good biocompatibility, so that the coating has bacterium killing and inhibiting properties and causes no toxic effect to cells.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a method for preparing an antibacterial coating on the surface of a titanium implant. Background technique [0002] Titanium has excellent mechanical properties and chemical stability in vivo, and is widely used in dental implants. After the titanium implant is implanted in the alveolar bone, its long-term success depends on two main factors, one is the osseointegration of the implant and the bone, and the other is the infection and secondary infection after implant placement. Current studies have proved that titanium implants can form a good combination with bone after implantation, and the failure of implantation is mainly caused by bacterial infection after implantation. Success rate plays an important role. Oral antibiotics and antibiotics adsorbed on the implant surface can effectively prevent the occurrence of infection. However, this antibacterial method has a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/34A61L27/30A61L27/54A61L27/56C23C18/44
CPCA61L27/306A61L27/34A61L27/50A61L27/54A61L27/56A61L2300/104A61L2300/404A61L2400/18A61L2420/08C23C18/44C08L5/08
Inventor 朱肖王浙君王贻宁
Owner WUHAN UNIV
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