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Surface mount method of mineralized collagen gradient coating for medical titanium implant

A technology of mineralized collagen and gradient coating, which is applied in the direction of electrolytic inorganic material coating, etc., can solve the problems of coating shedding, low bonding strength, and inability to play the role of coating, so as to achieve uniform coating distribution and accelerate early healing speed , good biocompatibility and bioresponsiveness

Inactive Publication Date: 2011-03-09
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Especially the latter, if the bonding strength is not high, the friction between the implant and the receptor will cause the coating to fall off during the process of implanting the implant into the receptor, so that the coating cannot play its role

Method used

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  • Surface mount method of mineralized collagen gradient coating for medical titanium implant
  • Surface mount method of mineralized collagen gradient coating for medical titanium implant
  • Surface mount method of mineralized collagen gradient coating for medical titanium implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1) The titanium substrate was ultrasonically cleaned in water and ethanol in sequence, and then cleaned with HF and HNO 3 The mixed acid solution corrosion, the concentration of HF in the mixed acid solution is 2.7M, HNO 3 The concentration is 3.9M, corroded for 2 minutes, and then kept in a 5M NaOH solution at 50°C for 24 hours, taken out and ultrasonically cleaned with a 1M HCl solution for 3 minutes, and finally heat-treated at 600°C for 2 hours to obtain Titanium substrate with a porous oxide layer on the surface (see figure 1 );

[0027] 2) Calcium nitrate is dissolved in water to prepare a calcium-containing aqueous solution with a calcium concentration of 40 mM, and ammonium dihydrogen phosphate is dissolved in water to prepare a phosphorus-containing aqueous solution with a phosphorus concentration of 80 mM, and the calcium-containing aqueous solution and the phosphorus-containing aqueous solution are stirred and mixed , to obtain A solution;

[0028] 3) Diss...

Embodiment 2

[0034] 1) The titanium substrate was ultrasonically cleaned in water and ethanol in sequence, and then cleaned with HF and HNO 3 The mixed acid solution corrosion, the concentration of HF in the mixed acid solution is 2.2M, HNO 3The concentration is 4.1M, corroded for 3 minutes, and then kept in a 5M NaOH solution at 50°C for 24 hours, taken out and ultrasonically cleaned with a 1M HCl solution for 2 minutes, and finally heat-treated at 600°C for 2 hours to obtain A titanium substrate with a porous oxide layer on the surface;

[0035] 2) Dissolve calcium chloride in water to prepare a calcium-containing aqueous solution with a calcium concentration of 60 mM, dissolve sodium dihydrogen phosphate in water to prepare a phosphorus-containing aqueous solution with a phosphorus concentration of 120 mM, and stir the calcium-containing aqueous solution and the phosphorus-containing aqueous solution Mix to obtain A solution;

[0036] 3) Dissolving the collagen in an acetic acid solut...

Embodiment 3

[0042] 1) The titanium substrate was ultrasonically cleaned in water and ethanol in sequence, and then cleaned with HF and HNO 3 The mixed acid solution corrosion, the concentration of HF in the mixed acid solution is 2.5M, HNO 3 The concentration is 4.5M, corroded for 2 minutes, and then kept in a 5M NaOH solution at 50°C for 24 hours, taken out and ultrasonically cleaned with a 1M HCl solution for 5 minutes, and finally heat-treated at 600°C for 2 hours to obtain A titanium substrate with a porous oxide layer on the surface;

[0043] 2) Calcium nitrate is dissolved in water to prepare a calcium-containing aqueous solution with a calcium concentration of 80 mM, and ammonium dihydrogen phosphate is dissolved in water to prepare a phosphorus-containing aqueous solution with a phosphorus concentration of 160 mM, and the calcium-containing aqueous solution and the phosphorus-containing aqueous solution are stirred and mixed , to obtain A solution;

[0044] 3) Dissolving the col...

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Abstract

The invention relates to a surface mount method of mineralized collagen gradient coating for medical titanium implant. Based on the effect of voltage and electrolyte composition on in-situ biomineralization self-assembly of collagen in electrolyte, permineralized calcium phosphate layer, mineralized collagen layer and unmineralized pure collagen layer are assembled from the titanium substrate upward in profile by electrochemical codeposition technology. The components and structure of the above product are similar to those of natural bones. The product of good biocompatibility and biological responsiveness can accelerate the osteointegration of implanted area and shorten the period of treatment. The strong binding force between the coating and the titanium substrate prevents the occurrence of coating shedding due to friction stress during the process of implantation. The coating provided by the invention is applicable to clinical applications.

Description

technical field [0001] The invention relates to a mineralized collagen gradient coating assembled on the surface of a medical titanium implant and a preparation method thereof. Background technique [0002] Titanium and its alloys are widely used as alternative materials in orthopedics and dentistry due to their good strength, toughness, hardness, biocompatibility and corrosion resistance, but the biological inertness and low biological activity of their metal implants limit their applications. . Bioglass and bioceramics are often used as second-generation biomaterials due to their good biological activity, but their mechanical properties are poor and difficult to meet the requirements of the human body. Therefore, biochemical modification of the surface of titanium substrates has gained great potential. focus on. Osteocytes are composed of HA (hydroxyapatite) crystals and collagen fibers on the molecular scale. HA can promote osseointegration because the bonding strength ...

Claims

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Application Information

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IPC IPC(8): C25D9/08
Inventor 翁文剑屠俊君程逵宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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