Preparation method of biological piezoelectric coating on surface of titanium-based material

A titanium-based and coating technology, which is applied in the field of surface modification of biomedical materials, can solve the problems of poor biological activity, drug loading, and drug release performance that cannot meet the needs of clinical controllable long-term treatment, so as to promote osseointegration, The effect of reducing the risk of loosening and complications and shortening the bone repair process

Active Publication Date: 2021-09-28
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a method for preparing a bio-piezoelectric coating on the surface of titanium-based materials, which solves the problem of the poor biological activity of existing titanium and titanium alloy bone implant materials, and the inability to meet clinical requirements in terms of drug loading and drug release. The problem of controlling the need for long-acting treatment

Method used

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  • Preparation method of biological piezoelectric coating on surface of titanium-based material
  • Preparation method of biological piezoelectric coating on surface of titanium-based material
  • Preparation method of biological piezoelectric coating on surface of titanium-based material

Examples

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Effect test

Embodiment 1

[0053] Preparation of Ba on the surface of pure titanium 0.85 Ca 0.15 Zr 0.10 Ti 0.90 o 3 Specific nanotube piezoelectric coating, specifically implemented according to the following steps:

[0054] Step 1, use SiC sandpaper to polish pure titanium until the surface is smooth, then immerse in the prepared acidic lotion for chemical polishing, pickle until no bubbles are generated, then ultrasonically clean with absolute ethanol and deionized water, and dry for backup use.

[0055] Step 2, add ammonium fluoride and deionized water to ethylene glycol at 0.5wt%, 2vol%, and stir evenly to obtain an electrolyte; use the platinum sheet as the cathode, and the pure titanium treated in step 1 as the anode, and fix the anode and the cathode. The distance between them is 5mm, the voltage of primary anodic oxidation is 60V, the time is 1h, the voltage of secondary anodic oxidation is 60V, and the time is 0.5h, so that the titanium sheet undergoes anodic oxidation reaction. Ultrason...

Embodiment 2

[0059] Preparation of Ba on the surface of titanium nails 0.85 Ca 0.15 Zr 0.10 Ti 0.90 o 3 Specific nanotube piezoelectric coating, specifically implemented according to the following steps:

[0060] Step 1, use SiC sandpaper to polish the titanium nails until the surface is smooth, then immerse in the prepared acidic lotion for chemical polishing, pickle until no bubbles are generated, then ultrasonically clean with absolute ethanol and deionized water, and dry for backup use.

[0061] Step 2, add ammonium fluoride and deionized water to ethylene glycol at 0.2wt%, 10vol%, and stir evenly to obtain an electrolyte; use the platinum sheet as the cathode, and the titanium nail treated in step 1 as the anode, and fix the anode and the cathode. The distance between them is 30mm, the voltage of the first anodization is 40V, the time is 4h, the voltage of the second anodization is 40V, the time is 1h, so that the anodization reaction occurs on the titanium nail, and the titanium...

Embodiment 3

[0065] Preparation of Ba on the surface of titanium alloy stent 0.85 Ca 0.15 Zr 0.10 Ti 0.90 o 3 Specific nanotube piezoelectric coating, specifically implemented according to the following steps:

[0066]Step 1, use SiC sandpaper to polish the titanium alloy bracket until the surface is smooth, then immerse in the prepared acidic lotion for chemical polishing, pickle until no bubbles are generated, then ultrasonically clean with absolute ethanol and deionized water, and dry Backup.

[0067] Step 2, add ammonium fluoride and deionized water at 0.6wt%, 5vol% to ethylene glycol and stir evenly to obtain an electrolyte; use the platinum sheet as the cathode, and the titanium alloy bracket treated in step 1 as the anode, and fix the anode and cathode The distance between them is 20mm, the voltage of primary anodic oxidation is 60V, the time is 1h, the voltage of secondary anodic oxidation is 60V, and the time is 0.5h, so that the anodic oxidation reaction of titanium alloy br...

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Abstract

The invention discloses a preparation method of a biological piezoelectric coating on the surface of a titanium-based material. The preparation method specifically comprises the following steps: preparing a titanium dioxide nanotube coating on the surface of the titanium-based material by adopting an anodic oxidation method, and carrying out ultrasonic treatment by using hydrochloric acid; then adding the product into an alkaline hydrothermal solution for hydrothermal reaction; and finally, cleaning and drying to form the biological piezoelectric coating on the surface of the titanium-based material. According to the method, the biological piezoelectric coating is formed on the surface of the titanium alloy, the biological piezoelectric coating has a nano structure, and a piezoelectric nanotube grows on the surface of the titanium-based material in situ and has good combination and nano effects with a matrix; meanwhile, the nanotube has a specific in-tube structure, has unique advantages in the aspects of medicine carrying and long-acting slow release, is beneficial to further treatment of bone injury parts, and accelerates the bone repair process. The piezoelectric property and the nano structure of the coating can promote the implant and nearby tissues to form effective bony combination, and the occurrence risk of looseness and complications is reduced.

Description

technical field [0001] The invention belongs to the technical field of surface modification of biomedical materials, and in particular relates to a preparation method of a bio-piezoelectric coating on the surface of a titanium-based material. Background technique [0002] Titanium and titanium alloy materials are currently the most widely used bone graft materials in the clinical treatment of bone defects. They are biologically inert and do not osseointegrate with surrounding tissues after implantation in the human body. They are easy to loosen, have many complications, and have a long cycle of new bone growth. and other insurmountable defects. Studies have found that human bone tissue has piezoelectric properties, that is, the force of human bone will cause the electron displacement of the local electric field to generate bioelectricity, which can act on the generation of growth factors and extracellular matrix, regulate bone growth, and shape and tissue reconstruction. P...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D11/26C23C26/00A61L27/06A61L27/30A61L27/50A61L27/54B82Y40/00
CPCC25D11/26C23C26/00A61L27/06A61L27/306A61L27/50A61L27/54B82Y40/00A61L2430/02A61L2300/602A61L2400/12
Inventor 赵康颜显懿汤玉斐朴钰程军华吴聪
Owner XIAN UNIV OF TECH
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