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Multi-component bone bonding material and a method of using the same

A kind of adhesive material and multi-component technology, applied in the field of medical materials, can solve the problems of surrounding tissue damage, inhibit the growth of new bone in the section, change the reaction ratio of components, etc., so as to facilitate the growth and regeneration of broken bones, overcome negative effects, The effect of high mechanical strength

Active Publication Date: 2019-01-25
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these traditional PMMA-based organic bone adhesives have the following disadvantages: During the curing process of bone bonding, the adhesive layer releases a large amount of heat that may cause damage to surrounding tissues; PMMA is generally not easy to degrade or be absorbed by the body, which may cause Inflammation at the site, which increases the risk of infection and may also inhibit the growth of new bone in the fractured area
In addition, a large amount of blood and tissue fluid often appear on the injured wound surface of the human body, and this watery environment has a great negative impact on the performance of polyurethane materials
Because a large amount of water will consume isocyanate groups and generate a large number of urea bonds. On the one hand, it will affect the adhesive strength of the material, and on the other hand, it will change the reaction ratio of the components, thus affecting the final adhesive performance of the material.

Method used

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  • Multi-component bone bonding material and a method of using the same
  • Multi-component bone bonding material and a method of using the same
  • Multi-component bone bonding material and a method of using the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] In a 150ml three-necked bottle equipped with nitrogen and a stirrer, heat up POLYCIN D290 (castor oil diol) and vacuumize and remove water for 2 hours, then add MDI with a molar ratio of 7 / 3 according to the molar ratio NCO / OH=1.05 (4,4'-diphenylmethane diisocyanate) and M20S (poly MDI), and then heated to 80 ° C, nitrogen protection reaction for 3 hours, to obtain light brown transparent polyurethane prepolymer. After the synthesis reaction of the polyurethane prepolymer is finished, samples are taken for titration, and the mass fraction of isocyanate is calculated.

[0060] Add 0.5wt.% catalyst F and pentamethyldiethylenetriamine (mass ratio 9 / 1) mixture to POLYCIN T400, and 1wt.% pure water, all calculated on the basis of POLYCINT400 weight, mix well and set aside to obtain ternary alcohol composition.

[0061] Test of bone adhesion performance in vitro: According to the formula of Example 1 in Table 1, add calcium carbonate powder, polyurethane prepolymer and trihy...

Embodiment 2

[0070] Compared with Example 1, except that calcium carbonate is replaced by β-tricalcium phosphate, other formulation processes remain unchanged. Likewise, in vitro bone adhesion experiments were performed in Environment 1.

Embodiment 3

[0072] Compared with Example 1, except that calcium carbonate is replaced by hydroxyapatite, other formulation processes remain unchanged. Likewise, in vitro bone adhesion experiments were performed in Environment 1.

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Abstract

The invention provides a multi-component bone bonding material, which relates to the field of medical materials, comprising an isocyanate composition, a castor oil polyol composition, a catalyst, anda particle size of 10-100um, and the inorganic particles contain a water-absorbent sulfate and a poorly soluble calcium salt, wherein the water-absorbent sulfate is distributed on the surface of the inorganic particles. The invention also provides a use method of a multi-component bone bonding material, wherein the obtained bonding material has the advantages of high bone bonding strength, no hindrance to the growth of broken bones and the like, in particular, is suitable for use in a human body temperature environment, and overcomes the negative influence on the performance of the bonding material under the environment with water.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a multi-component bone adhesive material and a use method. Background technique [0002] Medical bone cement is a new type of fracture fixation material, which is often used to attach small bone fragments and artificial implants to living bones, or for small area repair and reconstruction of bones. It has the advantages of convenient operation and strong applicability. , can overcome the problems of complex external fixation or metal internal fixation, easy secondary injury and easy infection. [0003] In recent years, commonly used medical bone adhesives (also known as bone adhesives) are divided into organic bone adhesives and inorganic bone adhesives. Among them, the organic bone adhesive is mostly formed by polymethyl methacrylate (PMMA) and its mixture. This polymer is made of acrylic monomers, such as methyl methacrylate (MMA), polymerized at room temperature in the presen...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/02A61L24/00
CPCA61L24/00A61L24/0005A61L24/02A61L24/046A61L2300/412
Inventor 郑震肖海军朱祺王新灵
Owner SHANGHAI JIAO TONG UNIV
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