Bone repair scaffold and preparation method thereof

Abstract

The invention belongs to the technical field of biomedicine materials, and particularly relates to a bone repair scaffold and a preparation method thereof. The bone repair scaffold is of a porous structure of the size matched with the size of a bone defect part of a patient. The preparation method of the bone repair scaffold comprises the steps that firstly, a design entity of the scaffold is built through three-dimensional design software; secondly, a three-dimensional model of a construction unit of a porous matrix structure is constructed; thirdly, the design entity is filled with the construction unit of the three-dimensional model through the three-dimensional design software, and the design entity is manufactured into the porous matrix structure; fourthly, the porous matrix structureis printed through a 3D printer, and a printed piece is obtained. The scaffold can be used for repairing bone defects, the osteogenesis and angiogenesis capacity can be improved, the scaffold can beimplanted into a large-segment bone defect or a cavity formed after the lesions of early femoral head ischemic necrosis are removed, and a biomechanical supporting effect and the effect of promoting the ingrowth of blood vessels and bone tissue are achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a bone repair bracket and a preparation method thereof. Background technique [0002] Large bone defects caused by trauma, infection, tumors and other diseases are still a great problem in clinical treatment. One of the reasons for the poor treatment effect is the avascularity of bone grafts or bone substitute materials: while the availability of oxygen and nutrients in the body Diffusion distance is only 200um. Most traditional bone grafts and tissue engineering bone substitutes do not have a microcirculatory system. The central area of ​​the graft does not receive the oxygen and nutrients it needs, which can lead to failure of the graft to heal. [0003] Necrosis of the femoral head is a common and refractory disease in the field of orthopedics. Without effective treatment, about 80% of patients will have femoral head collapse within 4 years, seconda...

AI Technical Summary

Problems solved by technology

Stem cell therapy, artificial bone filling materials, and scaffold therapy have been used in previous material research, but satisfactory therapeutic effects have not been achieved.

Because the important cause of femoral head necrosis is the damage or interruption of the blood supply in the lesion area, although these materials have good support or promote osteogenesis, it is difficult to rebuild the microcirculation system in the lesion area, so they cannot be the injection of stem cells or newborns. The bone tissue provides the necessary nutrition and removes metabolic waste, so that the ideal therapeutic effect cannot be obtained

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