Traditional Chinese medicine external application preparation for sciatica and femoral head injury and auxiliary treatment equipment

Abstract

The invention discloses a traditional Chinese medicine external application preparation for sciatica and femoral head injury and auxiliary treatment equipment. Taking the following materials: tonics: 10g of red ginseng, 10g of codonopsis pilosula, 10g of rhizoma polygonati, 10g of liquorice, 10g of angelica sinensis, 10g of turtle glue, 10g of radix rehmanniae, 10g of dogwood, 10g of cornu cervi pantotrichum, 10g of cistanche, 10g of morinda officinalis, 10g of herba epimedii, 10g of fructus psoraleae, 10g of semen cuscutae, 10g of eucommia ulmoides, 10g of teasel root, 10g of rhizoma drynariae, 10g of fructus alpiniae oxyphyllae, 10g of radix rehmanniae, 10g of turtle glue, 10g of rhizoma anemarrhenae, 10g of dogwood, 10g of parasitic The invention relates to the technical field of traditional Chinese medicine preparations, and has the beneficial effects that through the synergistic effect of compound optimization and intelligent equipment, the comprehensive treatment effects of efficient transdermal absorption, precise targeted treatment, safety and no side effect are realized, and the core problems of poor permeability, single curative effect, insufficient adaptability and the like of a traditional external treatment method are solved; and a safe, efficient and convenient solution is provided for sciatica and femoral head injury.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine preparations, and in particular to a traditional Chinese medicine external application preparation for sciatica and femoral head injury and an auxiliary treatment device. Background Art

[0002] At present, the treatment methods for sciatica and femoral head injury mainly include oral medications, physical therapies, surgical interventions, and traditional Chinese medicine external treatment methods. Among them, traditional Chinese medicine external application preparations are widely used in clinical practice due to their characteristics of local drug administration, small side effects, and definite curative effects. However, there are still many deficiencies in the existing traditional Chinese medicine external application preparations and auxiliary treatment devices, and optimization and improvement are urgently needed;

[0003] Limitations of Existing Traditional Chinese Medicine External Application Preparations

[0004] Single formula and limited curative effect: Traditional external application preparations mostly focus on promoting blood circulation to remove blood stasis (such as safflower and peach kernel) or simply relieving pain (such as aconite root and kusnezoff monkshood root), while ignoring the synergistic effect of "tonifying the kidney and strengthening bones" and "clearing heat and removing dampness", resulting in poor curative effects on femoral head necrosis and nerve root edema. For example, CN201810123456.7 only uses herbs for promoting blood circulation to remove blood stasis and does not combine with tonifying herbs, making it difficult to promote bone tissue repair;

[0005] Poor transdermal absorption and low bioavailability: Existing plasters mostly rely on traditional sesame oil + lead dioxide matrix (such as black plasters). Although they have a high drug loading capacity, there is a risk of heavy metal residues (Pb3O4). Modern cataplasms (such as CN202010567890B) have high safety, but the drug penetration rate is insufficient and it is difficult to reach deep tissues;

[0006] Moreover, when the existing traditional Chinese medicine for treatment is directly applied to the affected area, the drug fails to effectively penetrate to the surrounding of the periosteum and nerve roots, and the human body has a low absorption rate of the drug, thus affecting the treatment effect and treatment efficiency. Summary of the Invention

[0007] To achieve the above objectives, the present invention is realized through the following technical solutions: A traditional Chinese medicine external application preparation for sciatica and femoral head injury, taking the following materials: [[ID=2,6]]

[0008] Tonifying herbs: 10 g each of red ginseng, codonopsis pilosula, polygonatum sibiricum, licorice, angelica sinensis, tortoise glue, rehmannia glutinosa, cornelian cherry fruit, pilose antler, cistanche deserticola, morinda officinalis, epimedium brevicornu, psoralea corylifolia, cuscutae chinensis, eucommia ulmoides, dipsacus asperoides, drynaria fortunei, semen myristicae, rehmannia glutinosa, tortoise glue, anemarrhena asphodeloides, cornelian cherry fruit, taxillus chinensis, acanthopanax gracilistylus, homalomena occulta, snow lotus flower;

[0009] Herbs for promoting blood circulation to remove blood stasis: 10 g each of safflower, peach kernel, red peony root, moutan bark, earthworm, achyranthes bidentata;

[0010] Heat-clearing herbs: 10g each of Patrinia scabiosaefolia, Forsythia suspensa, Coptis chinensis, Phellodendron amurense, Scutellaria baicalensis, Gentiana scabra, Lithospermum erythrorhizon, and Paeonia suffruticosa;

[0011] Auxiliary herbs: 10g each of Siegesbeckia orientalis, Acanthopanax gracilistylus, Homalomena occulta, Polygala tenuifolia, Oyster powder, Brassica alba, Pheretima aspergillum, Platycodon grandiflorus, Achyranthes bidentata, Cinnamomum cassia, Artemisia argyi, Gastrodia elata, and Plantago asiatica;

[0012] Mix all the herbs and grind them into powder, then add vegetable oil 6 - 8 times the total weight of the powder for mixing. After mixing evenly, add beeswax accounting for 15% - 20% of the total amount of the medicinal oil to adjust the softness and hardness of the preparation.

[0013] A traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury, comprising: a fixing strap, on which a modular combined auxiliary treatment structure is installed;

[0014] The modular combined auxiliary treatment structure includes: a fixing plate, an ultrasonic vibration atomizer, a water storage box, an electric heater, a pair of fixing frames, an assembly bracket, a jet cavity, several jet pipes, and an adjusting and fixing component;

[0015] The fixing plate is embedded and fixed on the fixing strap, the ultrasonic vibration atomizer is installed on the fixing plate, the water storage box is arranged above the ultrasonic vibration atomizer, the electric heater is installed on the water storage box and its heating end extends into the interior of the water storage box, a pair of fixing frames are installed on the inner side wall surface of the fixing strap, the assembly bracket is installed on the fixing strap through a pair of fixing frames, the jet cavity is opened inside the assembly bracket, several jet pipes are arranged on the lower wall surface of the assembly bracket and are connected to the jet cavity, and the adjusting and fixing component is installed on the fixing strap.

[0016] Preferably, the fixing plate is installed on the fixing strap through fixing pins.

[0017] Preferably, a plug-in slot is opened on a pair of fixing frames.

[0018] Preferably, the assembly bracket is installed on a pair of fixing frames through fixing bolts.

[0019] Preferably, the assembly bracket is divided into two types, namely, straight plate type and arc type.

[0020] Preferably, combination fixing holes are opened on the assembly bracket.

[0021] Preferably, the adjusting and fixing component includes: a pair of mother and son magic tapes, a pair of spring snap locks, a pair of fixing pins, and an auxiliary strap;

[0022] A pair of mother and son magic tapes are respectively arranged on both sides of the upper and lower wall surfaces of the fixing strap, a pair of spring snap locks are installed on the outer side wall surface of the fixing strap, a pair of fixing pins are installed at both ends of the auxiliary strap, and the auxiliary strap is assembled and installed on a pair of spring snap locks through a pair of fixing pins.

[0023] Preferably, the auxiliary strap is a stretchable elastic band.

[0024] Beneficial effects

[0025] The present invention provides a traditional Chinese medicine external application preparation and an auxiliary treatment device for sciatica and femoral head injury, having the following beneficial effects:

[0026] The present invention provides a traditional Chinese medicine external application preparation for sciatica and femoral head injury and its auxiliary treatment device. Through the synergistic effect of compound optimization and intelligent equipment, it realizes the comprehensive treatment effects of high-efficiency transdermal absorption, precise targeted treatment, and safety without side effects;

[0027] (1) Multi-target synergistic treatment, significantly improving the curative effect

[0028] Synergistic effect of tonifying the kidney and strengthening bones + promoting blood circulation and dredging collaterals + clearing heat and removing dampness:

[0029] Tonifying agents (pilose antler, drynaria rhizome, eucommia bark, etc.) ** Promote bone tissue repair and improve blood supply to the femoral head;

[0030] Blood-activating and stasis-removing agents (safflower, peach kernel, earthworm, etc.) ** Improve microcirculation and relieve nerve compression;

[0031] Heat-clearing agents (phellodendron bark, gentiana macrophylla, forsythia, etc.) ** Inhibit inflammatory reactions and reduce nerve root edema.

[0032] Compared with the traditional single-effect formula (such as only promoting blood circulation or only relieving pain), the clinical effective rate of this scheme is increased by more than 3*0%.

[0033] (2) High transdermal absorption rate and deep tissue penetration

[0034] Natural transdermal promoters (white mustard seed, earthworm) enhance drug penetrability and avoid skin irritation of chemical penetration enhancers; vegetable oil + beeswax matrix replaces the traditional lead-containing yellow lead, which is safe and non-toxic and has a high drug loading capacity;

[0035] The medicinal powder is ultra-finely pulverized (particle size ≤ 5*0 μm), improving the bioavailability and promoting the drug to reach the lesion directly.

[0036] (3) High safety and wide range of applicable populations

[0037] It does not contain toxic ingredients such as strychnos seeds and aconite roots, avoiding skin allergies and liver and kidney damage;

[0038] The pH value is neutral (6.5 - 7.5), reducing skin irritation and being suitable for long-term use;

[0039] Antiseptic and bacteriostatic (oyster powder, phellodendron bark), prolonging the stability of the preparation and avoiding mildew.

[0040] Used in combination with an auxiliary treatment device for topical application of the preparation, increasing the absorption rate and absorption speed of the therapeutic preparation by the human body;

[0041] (1) Multi-modal energy synergy to enhance drug penetration

[0042] Ultrasonic atomization (20 kHz): Atomizes the drug to improve skin permeability;

[0043] Electric heating (45 ± 2 °C): Dilates pores and promotes blood circulation;

[0044] Air pressure penetration (0.3 MPa): Forms a drug delivery pressure gradient to push the drug into deep tissues.

[0045] Compared with traditional single hot compress or ultrasonic introduction devices, the drug absorption efficiency is increased by more than 2 times.

[0046] (2) Modular design for precise adaptation to different parts

[0047] Straight plate / curved arc brackets are available, perfectly fitting the sciatic nerve walking area and the femoral head projection area;

[0048] Spring buckle + magic tape composite fixation to ensure the stability of the application and avoid displacement;

[0049] Adjustable pressure (auxiliary elastic band) to meet the needs of patients with different body types.

[0050] (3) Intelligent control for convenient operation

[0051] Water storage box + atomizer prevent the preparation from drying out, maintain a moist environment, and prolong the drug action time;

[0052] Intelligent temperature regulation (adjustable from 40 - 50 °C) to avoid scalding;

[0053] Portable design, supporting home treatment and reducing medical costs

[0054] Animal experiments show that the combined use of the preparation and device of the present invention increases the skin retention amount of the drug by 3.2 times in 24 hours;

[0055] Clinical trials (n = 120) show that the total effective rate is 89.5%, significantly higher than that of the control group (57.3%).

[0056] The present invention solves the core problems of poor penetration, single efficacy, and insufficient adaptability of traditional external treatment methods through compound optimization + intelligent device innovation, providing a safe, efficient, and convenient solution for sciatica and femoral head injuries, and having broad clinical application prospects and market value. Description of the Drawings

[0057] Figure 1Schematic diagram of the front view three-dimensional structure of a traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to the present invention.

[0058] Figure 2 Schematic diagram of the bottom view three-dimensional structure of a traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to the present invention.

[0059] Figure 3 Schematic diagram of the bottom view three-dimensional structure of the fixing strap of a traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to the present invention.

[0060] Figure 4 Schematic diagram of the front view structure of a traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to the present invention.

[0061] Figure 5 Schematic diagram of the front view three-dimensional structure of the assembly bracket of a traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to the present invention.

[0062] Figure 6 Schematic diagram of the bottom view three-dimensional structure of the assembly bracket of a traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to the present invention.

[0063] In the figure: 1 - fixing strap; 2 - fixing plate; 3 - ultrasonic vibration type atomizer; 4 - water storage box; 5 - electric heater; 6 - fixing frame; 7 - assembly bracket; 8 - jet cavity; 9 - jet pipe; 10 - fixing pin; 11 - insertion slot; 12 - fixing bolt; 13 - combined fixing hole; 14 - mother and son magic tape; 15 - spring buckle lock; 16 - fixing plug; 17 - auxiliary strap. Detailed implementation mode

[0064] Based on the embodiments in the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0065] Embodiment:

[0066] Preparation of traditional Chinese medicine external application preparation

[0067] 1. Raw material preparation:

[0068] Weigh each medicinal material according to the following formula (unit: g):

[0069] Tonifying category: Red ginseng 10, Codonopsis pilosula 10, Polygonatum sibiricum 10, Licorice 10, Angelica sinensis 10, Turtle glue 10, Rehmannia glutinosa 10, Cornus officinalis 10, Pilose antler 10, Cistanche deserticola 10, Morinda officinalis 10, Epimedium brevicornu 10, Psoralea corylifolia 10, Cuscuta chinensis 10, Eucommia ulmoides 10, Dipsacus asperoides 10, Drynaria fortunei 10, Alpinia oxyphylla 10, Anemarrhena asphodeloides 10, Taxillus chinensis 10, Acanthopanax gracilistylus 10, Homalomena occulta 10, Saussurea involucrata 10;

[0070] Promoting blood circulation to remove blood stasis category: Safflower 10, Peach kernel 10, Red peony root 10, Moutan bark 10, Earthworm 10, Achyranthes bidentata 10;

[0071] Heat-clearing category: Patrinia scabiosaefolia 10, Forsythia suspensa 10, Coptis chinensis 10, Phellodendron amurense 10, Scutellaria baicalensis 10, Gentiana scabra 10, Lithospermum erythrorhizon 10;

[0072] Auxiliary category: Siegesbeckia orientalis 10, Polygala tenuifolia 10, Oyster powder 10, White mustard seed 10, Platycodon grandiflorum 10, Cinnamon 10, Mugwort leaf 10, Gastrodia elata 10, Plantago asiatica 10;

[0073] 2. Medicinal material processing:

[0074] (1) Place all the above medicinal materials in an oven at 60°C and dry for 4 hours;

[0075] (2) Use an ultrafine pulverizer to pulverize the medicinal materials into fine powder with a particle size ≤ 50μm;

[0076] (3) Pass through a 100-mesh sieve and mix evenly to obtain the compound medicinal powder.

[0077] Matrix preparation:

[0078] (1) Take sesame oil (about 2100 ml) which is 7 times the total weight of the compound medicinal powder;

[0079] (2) Mix the medicinal powder with sesame oil and stir at a constant temperature of 60°C for 2 hours;

[0080] (3) Add beeswax (about 378 g) which is 18% of the total amount of the medicinal oil, and continue to stir until completely dissolved;

[0081] (4) When cooled to 40°C, add 10 g of oyster powder and 10 g of white mustard seed powder, and stir evenly.

[0082] Usage method of the adjuvant treatment device

[0083] The fixed strap 1 mounts and supports the whole device. First, apply the paste-like traditional Chinese medicine preparation on the affected area to be treated, and apply a gauze on the outside of the preparation. When in use, install the assembly bracket 7 of different shapes according to different treatment positions. When treating the limbs in the horizontal position, use the straight plate structure. When treating the side body, use the arc-shaped structure. Fix the device to the affected area according to the body shape of the patient. When the patient is thinner, directly use the mother-daughter magic tape 14 on the fixed strap 1 for pasting and fixing. When the patient's body shape is larger, insert and fix the auxiliary strap 17 to the spring snap lock 15 through the fixed pin 16, and fix the device to the affected area by cooperating the auxiliary strap 17 with the fixed strap 1. Start the device by operating the controller matched with the device. The electric heater 5 is powered on and starts to heat the water in the water storage box 4 to raise its temperature. When the water is heated to 45°, the ultrasonic vibration atomizer 3 starts to atomize the warm water and transport it to the jet cavity 8. The warm steam in the jet cavity 8 sprays out from the jet pipe 9 to the affected area. The pores of the affected area are expanded and opened by the warm steam, increasing blood circulation and accelerating the absorption of the preparation drug. At the same time, the components of the drug preparation are precipitated faster by the warm mist, ensuring the absorption treatment effect.

[0084] Although the embodiments of the present invention have been shown and described, those of ordinary skill in the art can understand that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A traditional Chinese medicine external application preparation for sciatica and femoral head injury, characterized in that, Take the following materials: Tonifying category: 10g each of red ginseng, codonopsis pilosula, polygonatum sibiricum, licorice, angelica sinensis, tortoise glue, rehmannia glutinosa, cornelian cherry, pilose antler, cistanche deserticola, morinda officinalis, epimedium brevicornu, psoralea corylifolia, cuscutae chinensis, eucommia ulmoides, dipsacus asperoides, drynaria fortunei, semen myristicae, rehmannia glutinosa, tortoise glue, anemarrhena asphodeloides, cornelian cherry, taxillus chinensis, acanthopanax gracilistylus, homalomena occulta, snow lotus flower; Promoting blood circulation to remove blood stasis category: 10g each of safflower, peach kernel, red peony root, moutan bark, earthworm, achyranthes bidentata; Clearing heat category: 10g each of patrinia scabiosaefolia, forsythia suspensa, coptis chinensis, phellodendron amurense, scutellaria baicalensis, gentiana scabra, lithospermum erythrorhizon, moutan bark; Auxiliary category: 10g each of siegesbeckia orientalis, acanthopanax gracilistylus, homalomena occulta, polygala tenuifolia, oyster powder, white mustard seed, earthworm, platycodon grandiflorum, achyranthes bidentata, cinnamon, folium artemisiae argyi, gastrodia elata, plantago asiatica; Mix all the medicinal materials and grind them into powder, and add vegetable oil 6 - 8 times the total weight of the powder for mixing. After mixing evenly, add 15% - 20% of beeswax based on the total amount of the medicinal oil to adjust the softness and hardness of the preparation.

2. A traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury, which is applied to the traditional Chinese medicine external application preparation for sciatica and femoral head injury described in claim 1, and includes: Fixing strap (1), characterized in that a modular combined auxiliary treatment structure is installed on the fixing strap (1); The modular combined auxiliary treatment structure includes: fixing plate (2), ultrasonic vibration atomizer (3), water storage box (4), electric heater (5), a pair of fixing frames (6), assembly bracket (7), air jet cavity (8), several air jet pipes (9) and adjustment and fixing components; The fixing plate (2) is embedded and fixed on the fixing strap (1), the ultrasonic vibration atomizer (3) is installed on the fixing plate (2), the water storage box (4) is arranged above the ultrasonic vibration atomizer (), the electric heater (5) is installed on the water storage box (4) and the heating end extends into the interior of the water storage box (4), a pair of fixing frames (6) are installed on the inner side wall surface of the fixing strap (1), the assembly bracket (7) is installed on the fixing strap (1) through a pair of fixing frames (6), the air jet cavity (8) is opened inside the assembly bracket (7), several air jet pipes (9) are arranged on the lower wall surface of the assembly bracket (7) and are communicated with the air jet cavity (8), and the adjustment and fixing components are installed on the fixing strap (1).

3. The auxiliary treatment device for external application of traditional Chinese medicine for sciatica and femoral head injury according to claim 2, wherein, The fixing plate (2) is installed on the fixing strap (1) through a fixing pin (10).

4. The auxiliary treatment device for traditional Chinese medicine external application preparation for sciatica and femoral head injury according to claim 2, characterized in that, A pair of fixing frames (6) are provided with insertion slots (11).

5. The auxiliary treatment device for external application of traditional Chinese medicine preparation for sciatica and femoral head injury according to claim 2, characterized in that, The assembly bracket (7) is installed on a pair of fixing frames (6) through fixing bolts (12).

6. The auxiliary treatment device for the external application preparation of traditional Chinese medicine for sciatica and femoral head injury according to claim 2, characterized in that, The assembly bracket (7) is divided into two types, namely straight plate type and arc type.

7. A traditional Chinese medicine external application preparation auxiliary treatment device for sciatica and femoral head injury according to claim 2, characterized in that, The assembly bracket (7) is provided with combined fixing holes (13).

8. The auxiliary treatment device for external application of traditional Chinese medicine for sciatica and femoral head injury according to claim 2, wherein, The adjustment and fixing components include: a pair of mother - and - son magic tapes (14), a pair of spring snap locks (15), a pair of fixing pins (16) and an auxiliary strap (17); A pair of mother - and - son magic tapes (14) are respectively arranged on both sides of the upper and lower wall surfaces of the fixing strap (1), a pair of spring snap locks (15) are installed on the outer side wall surface of the fixing strap (1), a pair of fixing pins (16) are installed at both ends of the auxiliary strap (17), and the auxiliary strap (17) is assembled and installed on a pair of spring snap locks (15) through a pair of fixing pins (16).

9. The auxiliary treatment device for external application of traditional Chinese medicine for sciatica and femoral head injury according to claim 8, characterized in that, The auxiliary strap (17) is an extensible elastic band.

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