104 results about "Avascular necrosis bone" patented technology

The invention provides a method of correcting numerous bone abnormalities including bone tumors and cysts, avascular necrosis of the femoral head, tibial plateau fractures and compression fractures of the spine. The abnormality may be corrected by first accessing and boring into the damaged tissue or bone and reaming out the damaged and / or diseased area using any of the presently accepted procedures or the damaged area may be prepared by expanding a bag within the damaged bone to compact cancellous bone. After removal and / or compaction of the damaged tissue the bone must be stabilized.

Methods and devices are described for the regulation of bone morphogenetic protein gene expression in bone cells via the application of fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured bone. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone tissue that include generating specific and selective electric and electromagnetic signals that generate fields optimized for increase of bone morphogenetic protein gene expression and exposing bone to the fields generated by specific and selective signals so as to regulate bone morphogenetic protein gene expression in such bone tissue. The resulting methods and devices are useful for the targeted treatment of bone fractures, fractures at risk, delayed unions, nonunion of fractures, bone defects, spine fusions, osteonecrosis or avascular necrosis, as an adjunct to other therapies in the treatment of one or all of the above, and in the treatment of osteoporosis.

One embodiment of the present invention relates to an ankle prosthesis. Another embodiment of the present invention relates to a total ankle replacement prosthesis. Another embodiment of the present invention relates to an ankle replacement (partial or total) which is adapted, for example: (a) to treat arthritis of the ankle (e.g., ankle arthritis of any cause: after precious trauma; primary; malalignment induced; after hindfoot fusion; from recurrent ankle instability; rheumatoid or inflammatory arthritis; gout; local growth; dysplasia; growth plate arrest; avascular necrosis; hemophilia; distant septic event); (b) to revise a fused ankle; and / or (c) to treat trauma. The ankle replacement may be carried out by replacing one or more joint surfaces of an ankle joint. Another embodiment of the present invention relates to a method for inserting an ankle prosthesis.

The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate it's implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased new blood vessel growth and density in the avascular necrotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.

A method of treating avascular necrosis (“AVN”) comprising administering one or more osteoinductive formulations to the site of AVN disease progression. The method involves the combination of a core decompression technique, followed by the introduction of one or more osteoinductive formulations into the decompression core, and concluding with capping of the lateral aspect of the decompression core with a femoral core cap. The osteoinductive formulations of the invention comprise one or more osteoinductive agents and suitable carrier molecules. The femoral core cap retains the osteoinductive formulation within the decompression core, thereby preventing leakage of the osteoinductive formulation from the decompression core. The method of the invention optionally comprises introduction of autograft or allograft with the osteoinductive formulations of the invention. The method of the invention further optionally comprises incorporation of sustained release compositions to provide extended periods of osteogenesis.

Methods and devices are described for the regulation of Transforming Growth actor (TGF)-β1, β2, and / or β3 protein gene expression in bone cells and other tissues via the capacitive coupling or inductive coupling of specific and selective electric fields to the bone cells or other tissues, where the specific and selective electric fields are generated by application of specific and selective electric and electromagnetic signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective electric and electromagnetic signals that generate fields in the target tissue optimized for increase of TGF-β1, β2, and / or β3 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate TGF-β1, β2, and / or β3 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of bone fractures, fractures at risk, delayed unions, nonunion of fractures, bone defects, spine fusions, osteonecrosis or avascular necrosis, as an adjunct to other therapies in the treatment of one or all of the above, in the treatment of osteoporosis, and in other conditions in which TGF-β1, β2, and / or β3 protein may be implicated.

Disclosed therein is a big femoral head and femoral head surface replacement, which are used for hip osteoarthritis and vascular necrosis of femoral head. As a person get older and aged, the weight bearing hip joint is indispensably changed to osteoarthritis and sometimes showed avascular necrosis of the femoral head with unknown etiology. The deformed femoral head and hip joint should be replaced with the THA. Till now, the total hip replacement is performed in such a way that the necrosed femoral head and a healthy femoral neck are all removed and a femoral stem is inserted into the marrow cavity, and in this case, a small femoral head causes a reduction of a range of motion and dislocation of the hip joint occasionally, and osteolysis due to abrasion of plastic acetabular liner. In case of a conventional femoral head surface replacement (hereinafter, called “conventional FHSR”), a complication of femoral neck fracture and could not combined use with conventional THA. Recently, hard bearing system such as metal on metal THA or ceramic on ceramic THA without using plastic has been introduced to solve the problem of osteolysis due to abraded plastic particles generated when the THA is worn out as time goes. But there also have many problems as a limited range of motion, resected normal femoral neck and difficulties of rereplacement of the femoral stem. Because of the big femoral head or the FHSR can increase the range of motion and lower dislocation rate these devices are gradually widespread in young active person and Asian peoples. This invented design of the modularity gives the convenience to the surgeon and economically lower burden to patients to use of the FHSR and big femoral head system. The related accessory showed initial stability of the FHSR during operation and prevent from femoral neck fracture in follow-up periods.

The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

Methods and devices are described for the regulation of Transforming Growth actor (TGF)-β1, β2, and / or β3 protein gene expression in bone cells and other tissues via the capacitive coupling or inductive coupling of specific and selective electric fields to the bone cells or other tissues, where the specific and selective electric fields are generated by application of specific and selective electric and electromagnetic signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective electric and electromagnetic signals that generate fields in the target tissue optimized for increase of TGF-β1, β2, and / or β3 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate TGF-β1, β2, and / or β3 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of bone fractures, fractures at risk, delayed unions, nonunion of fractures, bone defects, spine fusions, osteonecrosis or avascular necrosis, as an adjunct to other therapies in the treatment of one or all of the above, in the treatment of osteoporosis, and in other conditions in which TGF-β1, β2, and / or β3 protein may be implicated

A system, including catheter apparatus, and related method for performing site specific therapy. The catheter apparatus can include one or more semipermeable microcatheters for use in performing site specific microdialysis. The system and method are particularly suited for use in addressing cerebral edema by affecting the osmolar relationship between fluids making up the brain tissue.Also disclosed is an apparatus having a delivery / recovery mechanism in the form of a pump reservoir and one or more catheters in the form of semipermeable microcatheters, for use in delivering and / or recovering fluid to and / or from a tissue site or for performing tissue engineering outside of the body. The apparatus can be used in a method to perform site specific microtherapy, including for the treatment of avascular necrosis, compartment syndrome, cerebral edema, and to improve skin flap survival in the course of reconstructive surgery.

By providing an elastic form stable material which is capable of being delivered directly to a specific desired location within a living creature and provides increased strength and rigidity to the injected location, disorders of the trabecular bone or subchondral tissue of a living creature are able to be effectively treated. Treatment of necrosis of the bone beneath the cartilage in skeletal joints and other defects in bony or cartilaginous structures is achieved with a variation of the subject material specific to each application. In the preferred method, the elastic form stable material is injected directly into the affected area, thereby achieving the desired result.

A method for manufacturing a spherical cage. The method includes providing a wire braid and inserting a spherical ball inside the wire braid. The wire braid and spherical ball are placed inside a mold. Excess wire braid is trimmed from the mold, creating trimmed ends of the braid. The mold is heat set with the spherical ball and wire braid. The spherical ball and wire braid are removed from the ball and the spherical ball is removed from the wire braid, resulting in a spherical wire cage.

The present invention relates to a prepuce cutting device, which solves the technical problem of the defect of the prior prepuce cutting device which can not expand along with the prepuce erection. The present invention provides an open-loop prepuce cutting device which comprises a cutting ring and a bandage; the external circumference of the cutting ring is provided with an annular groove and the bandage can bind the prepuce in the annular groove; the cutting ring with certain flexibility is provided with a fracture; the bandage can be a retractable flexible bandage and the flexible bandage can select sterilized and disinfected nylon line, suture, flexible rubber ring, etc., so the abundant prepuce of the patient is bound on the cutting ring and the partial prepuce naturally falls off due to avascular necrosis. As the cutting device is the open-loop design, the internal diameter can be automatically adjusted, and when the prepuce erects, the ring can expand, and when the penis weakens, the ring can synchronously shrink, thus greatly reducing the patient pain. The present invention with the advantages of simple structure, convenient use, low cost and less pain is applied in the prepuce cutting operation.

The invention discloses a urine-leakage-prevention and blockage-prevention catheter, which comprises a catheter body and a guide wire, wherein the center of the catheter body is a urine discharging passage; the front section of the catheter body is provided with a self-expansion opening section; the front end of the self-expansion opening section is provided with a cap-shaped front blind end; the middle section of the catheter body is provided with a urine-leakage-prevention air bag; an anti-sliding air bag is arranged between the urine-leakage-prevention air bag and the self-expansion opening section; the urine-leakage-prevention air bag and the anti-sliding air bag are connected to a multi-passage air bag inflating connector arranged at the back section of the catheter body through an inflating passage; the self-expansion opening section is connected with a flushing and medication connector arranged at the back section of the catheter body through a flushing and medication integral passage; the back end of the catheter body is a drainage outlet; and the drainage outlet is provided with an opening sealing cap. The urine-leakage-prevention and blockage-prevention catheter has the advantages that the complete blockage probability of the catheter caliber part is reduced; the injury on the human body is reduced; the retention of harmful urine in the bladder is reduced; and the mucomembranous avascular necrosis injury due to long-time compression of the urethra inner wall tissue by the air bag in the same position is avoided.

The invention discloses an expression method of Beclin1 and MAP1-LC3 (microtubule-associated protein 1-light chain 3) in steroid-induced avascular necrosis of femoral head of a rabbit, detection of a bone cell apoptosis index of a femoral head tissue of a rabbit SANFH (steroid-induced avascular necrosis of femoral head) model and the MAP1-LC3 expression shows that autophagy-related gene Beclin1 can regulate autophagy activity and also can selectively combine with family members of Bcl-2 (B-cell lymphoma-2) to regulate the cell apoptosis activity. By detection of the expression of the Beclin1 in the SANFH model, the expression method provides a new molecular target for treatment of SANFH. The expression method is simple and convenient in operation, better solves the problem that no study on cell apoptosis and autophagy expression and mutual relation thereof in the SANFH model is found at home and abroad, and fills the blank of the study on cell apoptosis and autophagy expression and the mutual relation thereof in an ANFH (avascular necrosis of femoral head) model.

The invention discloses a comfortable-to-use irritation-reduction trachea cannula, which comprises a main cannula, fixed sleeve bags, a lower absorption sleeve, an air injection tube and a lower absorption tube, wherein the appearance of the main cannula simulates the structure of the respiratory tract; the main cannula is made of flexible materials; at least two fixed sleeve bags are arranged on the main cannula; all of the fixed sleeve bags are communicated; the fixed sleeve bags are connected with the air injection tube; the insertion end of the main insertion tube is provided with the lower absorption sleeve; and the lower absorption sleeve is connected with the lower absorption tube. The comfortable-to-use irritation-reduction trachea cannula has the advantages that the irritation on the trachea is small; and the conditions of tracheal mucosa avascular necrosis and cough cannot easily occur; the insertion end of the main cannula is provided with the lower absorption sleeve; secreta generated on the trachea inner wall near an air flow hole can be absorbed and can be discharged out of the body through the lower absorption tube; secreta in the respiratory tract can be continuously cleared; and the occurrence of the catheter blockage condition is avoided.

This invention is a surgical method to treat a disease called osteonecrosis (Avascular necrosis, Aseptic necrosis) of the femoral head which is caused by interruption of blood supply to the femoral head. This method comprises several surgical techniques including circular incision of hip joint capsule, osteotomy through trochanteric area of the femur without detaching the greater trochanter, rotation of the femoral head and neck portion and internal fixation with screws. The purpose of these procedures is to make the femoral head rotated so that the intact portion of the femoral head can support the pelvis and the necrotic portion of the femoral head can be placed in the non-weight bearing portion.

The present invention relates to methods of treating pulmonary hypertension, facilitating joint fusion, facilitating tendon and ligament repair, reducing the occurrence of secondary fracture, treating avascular necrosis, facilitating cartilage repair, facilitating bone healing after limb transplantation, facilitating liver regeneration, facilitating wound healing, reducing the occurrence of gastric ulceration, treating hypertension, facilitating the growth of tooth enamel or finger or toe nails, treating glaucoma, treating ocular hypertension, and repairing damage caused by metastatic bone disease using an EP2 selective receptor agonist.

The invention relates to a circumcision device, which belongs to the field of medical instruments. The circumcision device comprises a supporting structure and a blocking structure, wherein the supporting structure and the blocking structure are matched together to finish circumcision. The circumcision device ensures that foreskin tissues to be removed generate avascular necrosis and fall off by blocking off blood supply, so a complete and smooth excision surface can be formed without bleeding and with little pain.

The invention discloses an experimental method of effects of DNA oxidative damage and bone cell apoptosis on avascular necrosis, the method comprises the following steps: experimental grouping and establishment of an animal model, preparation of specimens, histomorphology observation under a light microscope, observation by a transmission electron microscope, bone cell apoptosis situation detection by TUNEL (terminal dexynucleotidyl transferase(TdT)-mediated dUTP nick end labeling) method, bone marrow hematopoietic cell DNA oxidative damage detection by monoclonal antibody N45.1 immunohistochemistry method, and statistical analysis. According to the method, experiment animals are respectively killed in the second week and the fourth week after the last time of administration, and five animals are killed for each time in each group; bilateral femoral heads are taken for conventional fixed decalcification for stand-by testing, the number of vacant bone lacunas is counted by HE (hematoxylin-eosin) staining, the bone cell morphological change is observed by the electron microscope, the bone cell apoptosis situation is detected by the TUNEL method, the bone marrow hematopoietic cell DNA oxidative damage is detected by the immunohistochemistry method, and the relationship between SANFH ((steroid-induced avascular necrosis of femoral head)) and the bone marrow hematopoietic cell DNA oxidative damage and the bone cell apoptosis is explored, and provides new ideas for the further study of pathogenesis of the steroid induced avascular necrosis of femoral head.

An umbrella shaped memory alloy support in femoral head comprises an umbrella shaped support and a support sleeve, wherein the lower end of the umbrella shaped support is in sleeve joint with the support sleeve by an umbrella handle; the umbrella shaped support is formed by eight supporting ribs; the support sleeve is formed by rolling plates; blood supply holes are distributed on the wall of the support sleeve; and withdrawal preventing pawls are arranged on the outer surface of the support sleeve. The support not only plays a powerful supporting role in femoral head, but also can assist in revascularization of femoral head, prevent further collapse of femoral head, alleviate more pains of the patients, shorten the operation time and simplify the operation, is safe and reliable in supporting and has obvious effect on treating collapse of femoral head caused by adult avascular necrosis of femoral head. The support has simple process and shape, is easy to deform and insert, is stable in installation after complex, is convenient to use in operation and is secure and reliable in fixation.

The invention provides a biological packed agent to treat early avascular necrosis of femur head, which is mainly composed of fibrinogen, prothrombin and the bone marrow stromal stem cells of the transferred HGF gene. The reagents are injected into the rabbit femoral necrosis through the decompression tunnel with the duplex injector by the core decompression technology. The fibrinogen forms a three-dimensional network structure gel and then becomes the stent for transfer HFG gene bone marrow stromal cells and controls the cell secretion HFC slow release to prevent the loss of the transplanted transgenic bone marrow stromal cell under the effect of the prothrombin. In this way, the agent can keep HGF partial effect density and improve the blood vessel regeneration and bone reconstruction in the necrosis area.

In general, various embodiments of the present invention comprise an external fixation device, an internal fixation device, and a lower extremity stabilizer. The external fixation device is connected to the lower extremity stabilizer and the external fixation device is adjustably connected to the internal fixation device. The internal fixation device is capable of being attached to at least one bone in a patient's foot, ankle, and / or lower extremity. The system is capable of simultaneously compressing and stabilizing at least one bone for treating Charcot neuroarthropathy, fractures, revisional foot and ankle surgery including but not limited to malunions, nonunions, delayed unions, fibrous unions, avascular necrosis, resected osteomyelitis, incorporated autogenous and / or allogenic bone grafts for arthrodesis procedures, pseudoarthrosis and bones with decreased mineral density and cortical stiffness, and / or the like for any reconstructive and / or elective foot and ankle surgery where a compression arthrodesis is needed. The external fixation device and / or lower extremity stabilizer can be removed after a certain period of time, leaving the internal fixation system within the body for prolonged stabilization and maintenance of the arthrodesis site(s).

Devices, systems and methods for performing arthroscopic evaluations and procedures in and near the hip joint are provided. An arthroscopic probe having a Doppler probe disposed on a movable tip portion is useful for determining blood flow and for identifying vascular structures. An arthroscopic probe having a Doppler probe and a radiofrequency (RF) source disposed on a movable tip portion provides further useful features including the ability to perform cauterization, tissue ablation, and other RF procedures. The devices, systems, and methods are effective to assist an operating surgeon in the assessment of femoral head blood supply before, during, and after procedures involving the hip joint and optionally to provide for RF procedures in concert with such assessments of blood flow. The devices, systems, and methods of the present invention aid in arthroscopic procedures, and are useful in reducing the risk of iatrogenic hip joint avascular necrosis (AVN).

The invention relates to the field of medical instruments and provides a combined stent. The combined stent comprises a bone support (1), a proximal connector (2) and a distal connector (3), and pore channels (12) are formed in the bone support (1); the proximal connector (2) is connected to the tail of the bone support (1), and pore channels (12) are formed in the proximal connector (2); the distal connector (3) is connected to the tail of the proximal connector (2), pore channels (12) are formed in the distal connector (3), and after the bone support (1), the proximal connector (2) and the distal connector (3) form the stent by connection, the pore channels (12) therein are communication with one another. The combined stent can realize treatment of avascular necrosis of the femoral head by means of combined transplantation of blood vessels.

The invention relates to a traditional Chinese medicine compound for curing glucoticorticoid-induced avascular necrosis of the femoral head (SANFH) and aims at the problem of the SANFH that the obstacle of blood circulation causes the caput femoris ischaemia and the caput femoris vein backflow obstruction causes the increasing of the inner pressure of the caput femoris. The compound is prepared by using medicines which tonify Qi and blood, promote blood circulation, remove obstruction in channels, eliminate the blood stasis, enrich kidney essence and lubricate joint. The medicines particularly contain Astragalus mongholicus, the root of red-rooted salvia, fructus psoraleae, rhizoma alismatis, the root of bidentate achyranthes, fleece-flower root, tortoise plastron and daemonorops draco. The medicine compound of the invention solves the problem that the caput femoris vein backflow obstruction causes the increasing of the inner pressure of the caput femoris and has good effect on SANFH caused by other reasons.

The invention relates to a plaster for treating femoral head necrosis. Each serving of the plaster for treating avascular necrosis comprises the following raw materials by weight: 7-9g of centipede, 25-30g of lumbricus, 5-10g of long-noded pit viper, 15-20g of baiyao, 25-30g of malt, 15-20g of bighead atractylodes rhizome, 15-20g of borneol, 25-30g of root of three-nerved spicebush, 10-15g of pseudo-ginseng, 5-10g of myrrh, 5-10g of musk and 0.5-0.6kg of liquor. The plaster for treating femoral head necrosis is convenient to use, and has obvious effect.

A pin guide for the surgical operation of an avascular necrosis of a femoral head includes a guide body having a central pin guide hole extending along a centerline of the guide body and a plurality of side pin guide holes formed so as to make a specified angle with the central pin guide hole. The side pin guide holes are radially arranged around the central pin guide hole at a front side of the guide body and joined to the central pin guide hole at a rear side of the guide body.

The invention discloses a method for researching the effects of Dickkopf-1 and cell apoptosis in steroid-induced avascular necrosis of femoral head (SANFH). The method comprises the following steps: by taking the femoral head sample of SANFH taken through total hip replacement as an experiment group and taking the sample after the hip replacement for fracture of neck of femur as a contrast group, cutting the femoral head sample, fixing and decalcifying the cut femoral head sample to prepare slices, observing the morphologic change of osteocytes by an electronic microscope, observing the pathological change of the osteocytes by a light microscope, counting the vacant bone lacuna, detecting the expression of Dickkopf-1 by an immunohistochemical staining technique, thus exploring the effects of Dickkopf-1 and cell apoptosis in SANFH. The method can be used for providing assistance for early diagnosis and curing of SANFH and also providing a theoretical basis for clinical prevention and curing of SANFH in future.

The invention discloses a Chinese herbal medicine preparation used for treating avascular necrosis of femoral head. The preparation is prepared from 10-15 parts of ligusticum, 3-9 parts of incised notopterygium rhizome and root, 10-25 parts of dragon's blood, 2-3 parts of common monkshood mother-root, 6-10 parts of Chinese quince, 6-12 parts of angelica dahurica, 5-10 parts of weeping forsythia fruit, 5-10 parts of fourstamen stephania root, 3-6 parts of safflower, 5-10 parts of drynaria, 6-10 parts of radix dipsaci, 3-5 parts of bamboo-living shiraia stroma, 2-3 parts of catechu, 4-8 parts of native copper, 2-6 parts of myrrh, 5-10 parts of frankincense, 3-6 parts of achyranthes bidentata, 5-10 parts of Chinese ephedra herb, 2-3 parts of kusnezoff monkshood mother-root, 5-10 parts of cucumber seed, 3-6 parts of rheum, 2-4 parts of saposhnikovia divaricata, 1-3 parts of borneol, 6-12 parts of lumbricus, 2-4 parts of heterophyllous wingseedtree root or stem, 2-4 parts of justicia procumbens, 4-6 parts of giantleaf ardisia rhizome, and 3-9 parts of gynura rhizome. The Chinese herbal medicines are decocted into a thick solution. The solution is filtered, recovered, bottled, sterilized, and preserved for later use. The Chinese herbal medicine preparation provided by the invention is advantaged in simple production technology, easy operation, convenient application, safe administration, and no toxic or side-effect.