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Preparation method of helical flexible pressure-resistance nerve conduit

A nerve conduit and helical technology, applied in the direction of catheters, devices with human tubular structures, etc., can solve the problems of impaired function, limited nerve sources, and it is difficult to avoid wrong nerve bundles, so as to improve speed and quality, and repair peripheral nerves. Effects of nerve damage

Inactive Publication Date: 2009-08-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these repair methods have certain defects. It is difficult to avoid the wrong alignment of nerve bundles, curling and escape of nerve stumps, and hyperplasia of connective tissue at the anastomosis. Autologous nerve transplantation is bound to be accompanied by functional impairment of the donor site. , and the sources of nerves available for transplantation are limited

Method used

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  • Preparation method of helical flexible pressure-resistance nerve conduit
  • Preparation method of helical flexible pressure-resistance nerve conduit
  • Preparation method of helical flexible pressure-resistance nerve conduit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 0.6g of polylactic acid-caprolactone P(LLA-CL)[75:25] with an electronic balance, dissolve it in 10mL of dichloromethane, stir and oscillate until completely dissolved. The micron fiber bundles are wound on a stainless steel tube with a diameter of 4 mm, and the distance between the fiber bundles on the stainless steel tube is 0.5 cm. Electrospinning was performed on the solution, the applied voltage was 20kv, the receiving distance was 15cm, the spinning speed was 1.0mL / h, the diameter of the spinneret was 0.9mm, and the rotational speed of the receiving shaft was 1000r / m. P(LLA-CL) nerve guides are available in a 4mm diameter helix.

example 2

[0028] Weigh 0.8 g of collagen with an electronic balance, dissolve it in 10 mL of hexafluoroisopropanol, stir and oscillate until completely dissolved. The micron fiber bundles are wound on a stainless steel tube with a diameter of 4 mm, and the distance between the fiber bundles on the stainless steel tube is 0.3 cm. Electrospinning was performed on the solution, the applied voltage was 18kv, the receiving distance was 15cm, the spinning speed was 1.0mL / h, the diameter of the spinneret was 0.9mm, and the rotational speed of the receiving shaft was 1500r / m. Collagen nerve guides are available in a helical shape with a diameter of 4 mm.

example 3

[0030] Weigh 0.6 g of polylactic acid PLLA with an electronic balance, dissolve it in 10 mL of trifluoroethanol, stir and oscillate until completely dissolved. The micron fiber bundles are wound on a stainless steel tube with a diameter of 3 mm, and the distance between the fiber bundles on the stainless steel tube is 0.3 cm. Electrospinning was performed on the solution, the applied voltage was 17kv, the receiving distance was 12cm, the spinning speed was 1.0mL / h, the diameter of the spinneret was 0.9mm, and the rotational speed of the receiving shaft was 1000r / m. PLLA nerve guides are available in helical shapes with a diameter of 3 mm.

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Abstract

The invention relates to a method for preparing spiral flexible anti-pressure nerve conduits. The method comprises the following steps that: (1) a receiving device is prepared by winding a micron fiber bundle on a stainless steel tube at intervals of between 0.2 and 0.8 centimeter; (2) a polymer is dissolved in an organic solvent and prepared into a uniform spinning solution of which the concentration is between 0.03 and 0.12 gram / milliliter; and (3) the spinning solution is subjected to electrostatic spinning, and the spiral nerve conduits are obtained by use of the receiving device in a step (1). The method has the advantages of finding a combination point of the electrostatic spinning technology and the nerve regeneration field, making great breakthrough in the aspects of regenerating and repairing peripheral nerves and promoting the development of regeneration medicine. The prepared nerve conduits are easy to bend and resistant to pressure, are used for repairing peripheral injured nerves, and raise the speed and quality of nerve regeneration.

Description

technical field [0001] The invention belongs to the field of nerve guide preparation, and in particular relates to a preparation method of a spiral flexible and pressure-resistant nerve guide. Background technique [0002] With the improvement of industrial production mechanization and the development of transportation, the incidence of peripheral nerve injury is on the rise. In our country, there are about 2 million cases of this kind of nerve injury every year. Nowadays, microsurgical techniques are usually used to suture end-to-end adventitia of short-distance peripheral nerve defect to restore the function of nerve. The application of autologous nerve transplantation or other nerve substitutes can solve the problem of nerve defect. However, these repair methods have certain defects. It is difficult to avoid the wrong alignment of nerve bundles, curling and escape of nerve stumps, and hyperplasia of connective tissue at the anastomosis. Autologous nerve transplantation is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/06A61L29/04A61L29/12A61F2/04
Inventor 莫秀梅苏艳李晓强
Owner DONGHUA UNIV
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