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High-artificial tissue engineering nerve repair material NGCS and preparation method thereof

A nerve repair and tissue engineering technology, applied in medical science, prosthesis, etc., can solve the problems of affecting the effect of treatment or experiment, unfavorable directional growth of regenerative fibers, unable to maintain physical structure, etc., to achieve beneficial regeneration and improve mechanical properties. , Axial parallel arrangement height simulation effect

Active Publication Date: 2009-07-08
SHENZHEN YINGPULAN MEDICAL DEVICE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, because the internal structure of the previous composite bridging carrier materials has no certain rules (in terms of pore size and direction), the ideal physical structure cannot be maintained in the body, which is not conducive to the directional growth of regenerated fibers in spinal cord or peripheral nerve segmental injuries, thus affecting The effect of a treatment or experiment
Preparation of collagen-chitosan bridging materials with simulated structural features of axis-oriented microtubule matrix arrangement, there is no similar report in the world

Method used

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  • High-artificial tissue engineering nerve repair material NGCS and preparation method thereof
  • High-artificial tissue engineering nerve repair material NGCS and preparation method thereof
  • High-artificial tissue engineering nerve repair material NGCS and preparation method thereof

Examples

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Effect test

Embodiment 1

[0046] Embodiment 1: (according to type I collagen: chitosan: the ratio of gelatin is 280:70:70):

[0047] According to technical scheme of the present invention, taking collagen protein, gelatin and chitosan as example, its preparation method is carried out as follows:

[0048] 1). Weigh the above-mentioned type I collagen in parts by weight, put it into 3 mg / ml acetic acid solution at a concentration of 28 mg / ml, and dissolve it for 24 hours;

[0049] 2). Stir at 15000r / min for 90min in a constant temperature environment at 4°C to make a suspension;

[0050] 3). In addition, weigh chitosan and gelatin in the above weight ratio according to the ratio and add them to 3 mg / ml acetic acid solution to dissolve for 24 hours;

[0051] 4).Stir at 4°C and stir at 15000r / min for 90min to make a suspension;

[0052] 5). Mix the two suspensions and keep the constant temperature at 4°C, stir at 15000r / min for 90 minutes to make a suspension of collagen and chitosan, and leave it for 12...

Embodiment 2

[0060] Embodiment 2: adopt collagen (type I), chitosan and gelatin as raw material, its weight is respectively 280mg, 280mg, 280mg, implementation process is the same as example 1.

Embodiment 3

[0061] Embodiment 3: adopt collagen (type I), chitosan and gelatin as raw material, its weight is respectively 280mg, 28mg, 28mg, implementation process is the same as example 1.

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Abstract

The invention relates to a high simulation tissue engineering nerve repairing material NGCS and a preparing method thereof which is characterized in that the NGCS material comprises one, two or three raw materials of type I collagen, chitosan and gelatin. The NGCS material is made of the following raw materials by weight portions: 1-10 portions of type I collagen, 1 portion of chitosan and 1 portion of gelatin. The NGCS can be applied to both the basic research of the nerve injury repairing and the bridge repairing of clinical human spinal and peripheral nerve injuries or defects. The NGCS material is beneficial for the growth of nerve regenerated fiber and can be applied to the repairing of spinal and peripheral nerve injuries.

Description

technical field [0001] The invention relates to various biological raw materials such as collagen, gelatin and chitosan, as well as their processing techniques and production methods, and more precisely, is a highly simulated tissue engineering nerve repair material NGCS and a preparation method thereof. Background technique [0002] The repair of nerve damage is a worldwide problem. In recent years, the application of tissue engineering technology to prepare repair scaffold materials and assemble tissue engineering substitutes to repair nerve injuries has become a research hotspot. Compatibility and degradability studies; (2) Combined application of scaffolds, extracellular matrix and neurotrophic factors; (3) Introduction of seed cells. Among them, the scaffold is used as the carrier of seed cells and neurotrophic factors, and as the main body of the microenvironment for repairing nerve damage. The research on its construction and performance improvement has become the ke...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/22A61L27/20A61L27/56
Inventor 罗卓荆胡学昱黄景辉
Owner SHENZHEN YINGPULAN MEDICAL DEVICE
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