Orientated nano fiber bionic nerve conduit and manufacturing method thereof

A nerve conduit and nanofiber technology, applied in the field of nerve repair conduit and its production, can solve the problems of poor application effect and poor nerve regeneration effect, and achieve accelerated nerve regeneration speed, excellent tensile strength and shape maintenance ability, The effect of high fiber orientation
CN102525689AActive Publication Date: 2012-07-04SHANGHAI SIXTH PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI SIXTH PEOPLES HOSPITAL
Publication Date
2012-07-04

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Abstract

The invention provides an orientated nano fiber bionic nerve conduit and a manufacturing method thereof. A nano fiber membrane with orientation degree larger than or equal to 75% is prepared by means of coaxial electrostatic spinning, and then is curved to form the nerve conduit, NGF (nerve growth factor) is added into fibers so that the bionic nerve conduit is combined with various factors promoting nerve regeneration, such as 'nano bionics', 'contact guiding', 'drug release' and the like, and the bionic nerve conduit can effective promote nerve regeneration as proved by animal experiments.
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Description

technical field

[0001] The invention relates to a nerve repair conduit and a manufacturing method thereof, in particular to a nerve conduit capable of rapidly promoting nerve growth and a manufacturing method thereof. Background technique

[0002] The nervous system controls the sensory and motor functions of the human body. Once a nerve is damaged, it means the loss of sensory and motor functions in certain parts, which brings great pain to patients. Therefore, nerve repair and regeneration have become the focus of attention. Autologous nerve transplantation is the most classic method of clinically repairing nerve injury, but this method needs to cut out the patient's self-reported healthy nerve, which not only increases the surgical site, but may also cause dysfunction in the innervation area; while allogeneic nerve transplantation requires combined application of immune Inhibitors have a lower transplant success rate. Therefore, the repair of peripheral nerve injuries ha...

Claims

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