Piezoelectric stent composition capable of realizing self-generating electricity stimulation as well as preparation method and application thereof

Abstract

The invention, which relates to the technical field of biomedicine, provides a piezoelectric stent composition capable of realizing self-generating electricity stimulation as well as a preparation method and application thereof. The composition is composed of a biodegradable metabolic material and a piezoelectric material. With a 3D printing, jetting, pouring, extruding, die forming or electrostatic spinning method, the co-melt of the biodegradable material and the piezoelectric material or an organic solvent is formed into various biomedical application stents, especially nerve conduit stents. According to the invention, the mechanical energy in an in-vivo environment can be into electrical stimulation to promote regeneration, proliferation and differentiation of nerves, muscles, bones, blood vessels and the like without implantation of an external power supply or an electrode. The piezoelectric stent composition has advantages of being simple to prepare, low in cost, easy to controlin quality, wide in application range and the like. Rat in-vivo experiments show that the piezoelectric catheter stent has functions of promoting nerve regeneration and angiogenesis, relieving muscleatrophy and the like and has the broad clinical application prospects.

Description

technical field [0001] The invention relates to the field of biomedical technology, in particular to a piezoelectric scaffold composition capable of spontaneous electrical stimulation, a preparation method and application thereof. Background technique [0002] Peripheral nerve injury is a common disease worldwide. Traffic accidents, industrial injuries, natural disasters, wars, and cancers can all cause peripheral nerve damage. Large nerve defects cannot be sutured, and must be repaired by nerve transplantation or artificial nerve guides; nerve guides have certain strength, elasticity, and hardness, and can guide nerves. growth, provide mechanical support, and provide a good microenvironment for nerve regeneration; because the speed of nerve regeneration is usually very slow, it has been found through research that electrical stimulation can promote nerve regeneration, so people have studied a variety of conductive nerve guides, which are comparable to electrical stimulation...

AI Technical Summary

Problems solved by technology

[0004] This method uses glucose and oxygen in the body to generate energy for spontaneous electrical stimulation in the nerve conduit. However, since the conduit is not degradable, if the conduit is not treated after the nerve regeneration is completed, it may cause tissue fibrosis, inflammation and other toxic side effects, and After the treatment, a second operation to remove the implant is required, causing secondary harm to the patient

[0005] Moreover, clinical trials have proved that inflammation and glial hyperplasia are easily caused by the invasion of implanted electrodes; the clinical application effect is not very ideal

At present, various biodegradable materials have been developed to prepare various biomedical stents or catheters, such as collagen, polylactic acid, etc., but there are still some problems when using these materials alone, such as: unsuitable strength, material degradation rate and tissue regeneration speed Disadvantages such as mismatch and toxic side effects

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