A multi-channel conductive nerve repair catheter with fluorescent properties and its preparation method

A technology of fluorescence characteristics and nerve repair, which is applied in the directions of pharmaceutical formulations, prostheses, drug delivery, etc., can solve the problems of limited carbon nanotubes and non-degradable carbon nanotubes, and achieve the effects of improving dispersion, not easy to collapse, and ensuring electrical conductivity

Active Publication Date: 2021-04-06
BEIJING UNIV OF CHEM TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, carbon nanotubes are non-degradable in the body. During the regeneration and repair of nerves, when biodegradable materials degrade over time, carbon nanotubes will still form non-degradable fragments. , and the whereabouts in the body have become a matter of great concern to everyone
Establishing an in situ dynamic tracing technique for carbon nanotubes in vivo along with nerve regeneration is an effective means to study whether conductive biodegradable polymer composite carbon nanotube nerve conduits can be applied in vivo. Reports of in situ tracking in repair are limited, therefore, nerve conduits with in vivo imaging properties have become a research hotspot in this field

Method used

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  • A multi-channel conductive nerve repair catheter with fluorescent properties and its preparation method
  • A multi-channel conductive nerve repair catheter with fluorescent properties and its preparation method
  • A multi-channel conductive nerve repair catheter with fluorescent properties and its preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Add 2g of carboxylated MWCNTs, 98ml of absolute ethanol, 2ml of silane coupling agent KH550, and 2ml of acetic acid into a round bottom flask, and react at 50°C for 24h. The product was washed with absolute ethanol, collected by vacuum filtration, and dried in a vacuum oven at 40°C for 24 hours to obtain MWCNTs-NH 2 .

[0035] (2) Add 0.8g MWCNTs-NH to the round bottom flask 2 , 25ml tetrahydrofuran and 3ml triethylamine, put the device in an ice bath, slowly add 6ml tetrahydrofuran and 3ml α-bromoisobutyryl bromide BIBB dropwise. After dropping, react at 40°C for 72h. The product was washed with absolute ethanol until the liquid became colorless and transparent, the product was collected by vacuum filtration, and dried in a vacuum oven at 40° C. for 24 hours to obtain MWCNTs-Br.

[0036] (3) Add 0.2g MWCNTs-Br, 15ml dimethylformamide, 3ml glycidyl methacrylate monomer GMA into a round bottom flask, and after nitrogen gas for 30min, add 0.027g CuBr, 0.08ml pentam...

Embodiment 2

[0048] (1) Add 2g of carboxylated MWCNTs, 98ml of absolute ethanol, 2ml of silane coupling agent KH550, and 2ml of acetic acid into a round bottom flask, and react at 50°C for 24h. The product was washed with absolute ethanol, collected by vacuum filtration, and dried in a vacuum oven at 40°C for 24 hours to obtain MWCNTs-NH 2 .

[0049] (2) Add 0.8g MWCNTs-NH to the round bottom flask 2 , 25ml tetrahydrofuran and 3ml triethylamine, put the device in an ice bath, slowly add 6ml tetrahydrofuran and 3ml α-bromoisobutyryl bromide BIBB dropwise. After dropping, react at 40°C for 72h. The product was washed with absolute ethanol until the liquid became colorless and transparent, the product was collected by vacuum filtration, and dried in a vacuum oven at 40° C. for 24 hours to obtain MWCNTs-Br.

[0050] (3) Add 0.2g MWCNTs-Br, 15ml dimethylformamide, 3ml glycidyl methacrylate monomer GMA into a round bottom flask, and after nitrogen gas for 30min, add 0.027g CuBr, 0.08ml pentam...

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Abstract

The present invention relates to a multi-channel conductive nerve repair catheter with fluorescence characteristics and a preparation method thereof. The arrayed nanofibers are biodegradable aliphatic polyester nanofibers containing carbon nanotubes with fluorescent properties. The catheter prepared by the invention has photoluminescent properties and electrical conductivity, can be imaged in vivo, and can be used for nerve regeneration and repair. The parallel multi-channel structure of the catheter provides a certain mechanical strength, the oriented conductive fibers can promote the proliferation and differentiation of nerve cells, and the fluorescent carbon nanotubes provide an effective characterization of its existence and whereabouts in the regenerative nerve. means.

Description

technical field [0001] The invention relates to the field of biological materials, and relates to a nerve repair catheter and a preparation method thereof, in particular to a multi-channel conductive nerve repair catheter with fluorescence characteristics and a preparation method thereof. Background technique [0002] Peripheral nerve injuries from mechanical, physical, ischemic, and metabolic causes are common. Peripheral nerve injury often causes sensory, motor, and autonomic dysfunction in its innervated area, seriously affecting the quality of life of patients. How to promote the regeneration and functional reconstruction of injured peripheral nerves has always been a hot and difficult research topic in the field of neuroscience at home and abroad. The current gold standard for repairing peripheral nerve injuries is autologous nerve transplantation, but this practice has disadvantages such as insufficient donors, complications, multiple operations, and immunosuppression...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/16A61L27/08A61L27/50A61L27/58
CPCA61L27/08A61L27/16A61L27/50A61L27/58A61L2400/12A61L2400/18A61L2430/32C08L33/10
Inventor 蔡晴黄子容贾晓龙景伟陈国强王林杨小平
Owner BEIJING UNIV OF CHEM TECH
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