Antidepressant

Abstract

A PKB (Akt) activating agent comprising a compound represented by the formula (I): wherein R1 and R2: H, a hydrocarbon group or a heterocyclic group or R1 and R2 form a ring in cooperation with the adjacent carbon atom; R3: H, a hydrocarbon group or a heterocyclic group; W: represents a group represented by the formulas: wherein ring A: an optionally substituted benzene ring; ring B: an optionally substituted 5- to 7-membered nitrogen-containing heterocycle; R4: an aliphatic hydrocarbon group substituted with an aromatic group and further optionally substituted, or an acyl group containing an aromatic group; R5: H, C1-6 alkyl or acyl; R4c: an aromatic group, an aliphatic hydrocarbon group or acyl; and X:O or S; Y:O, S or NH; and ring C: an optionally substituted benzene ring, or a salt or a prodrug thereof, and use of the activating agent in prevention or treatment of depression, anxiety, manic-depressive psychosis or PTSD are provided.

Description

TECHNICAL FIELD [0001] The present invention relates to protein kinase B (hereinafter, referred to as PKB in some cases) activating agents and use of these PKB activating agents for preventing or treating depression, PTSD, Parkinson's disease, Alzheimer's diseases, and the like. BACKGROUND ART [0002] Protein kinase B (PKB) is also referred to as Akt, is one of protein phosphorylases, transmits stimuli from the extracellular to the inside of a cell, and is known to be involved in response of a cell to these stimuli. In particular, it is suggested that a signal transduction from phosphatidylinositol-3 (hereinafter, referred to as PI-3) is involved in nerve cell survival, nerve regeneration or nerve differentiation. Further, a method of treating diseases such as diabetes with an inhibitor of glycogen synthase kinase-3β (hereinafter, referred to as GSK in some cases) which is one of substrates of PKB is also known. However, PKB activation and effects of treating neurodegenerative diseas...

AI Technical Summary

Benefits of technology

[0008] In order to achieve the above objects, the present inventors intensively studied drugs which exert actions or effects of nerve regeneration, nerve neogenesis, and nerve survival maintenance together with clarification of action of mechanism and, as the result, found that the compound represented by the following formula (I) has excellent PKB activating activity, and further found out that compounds having the PKB activating activity can be a useful drug for preventing or treating Parkinson's diseases, by promoting nerve regeneration, and maintaining / protecting survival of a nerve cell, including nerve neogenesis.

Problems solved by technology

However, PKB activation and effects of treating neurodegenerative diseases such as Parkinson's disease are not necessarily confirmed in vitro.

However, those replacement therapeutic agent and symptomatic therapeutic agent do not suppress progression of neurodegeneration, and effects are gradually lost with disease progression.

Further, in neurodegenerative diseases, it is considered that a majority of nerve cells are degenerated at sideration, and it is thought that only degeneration suppression or promotion of regeneration of nerve ending can not regenerate sufficient function.

Previously, it has been thought that when neurodegeneration occurs in a central nervous system, recovery of function is difficult since nerve is not newly produced and replenished.

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