Fluoro comzole coordination polymer, preparation method and use

A coordination polymer, fluconazole technology, applied in the preparation of organic compounds, organic compounds/hydrides/coordination complex catalysts, copper organic compounds, etc., can solve the difficulty of catalyst recovery, poor selectivity of diol, Solvent pollution of the environment and other problems, to achieve potential economic benefits, good selectivity, good selectivity

Inactive Publication Date: 2005-03-23
ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In order to solve a series of problems such as poor selectivity, low yield, difficult catalyst recovery, and solvent pollution of the environment generated by the hydroxylation of phenol, the present invention provides a nitrogen-containing organic compound fluconaz

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0031] Example 1:

[0032] Preparation of fluconazole coordination polymer: add 15ml fluconazole methanol solution (0.04mmol.ml -1 ) Add dropwise to 6ml FeCl 2 .4H 2 O in methanol solution (0.05mmol.ml-1 ), stir evenly, and stand still at room temperature. After one month, yellow crystals are formed to obtain fluconazole iron coordination polymer with a yield of 73%. After X-single crystal diffractometer analysis, it is a coordination polymer with a two-dimensional network structure. The molecular formula is: (C 28 H 32 Cl 2 F 4 FeN 12 O 4 ) n .

[0033] Used as a catalyst: add 0.5g of phenol to the container, add 15ml of water as solvent, stir and add 10mg of fluconazole iron coordination polymer (as catalyst), and when heated to 40℃ under stirring, add H 2 O 2 (30%) 0.5ml starts timing, and stops the reaction after 1 hour. The reaction product was detected by high performance liquid chromatography. The result showed that the conversion rate of phenol was 62%, the content of cate...

Example Embodiment

[0034] Example 2:

[0035] The methanol solution of 20ml fluconazole (0.04mmol.ml -1 ) Add dropwise to 8mlCdCl 2 .2.5 H 2 O in methanol solution (0.05mmol.ml -1 ), stir uniformly, and stand still at room temperature. After 3 days, a colorless single crystal is formed to obtain a fluconazole cadmium coordination polymer with a yield of 79%. After X-single crystal diffractometer analysis, it is a two-dimensional network structure coordination polymer, the molecular formula is: (C 28 H 32 Cl 2 F 4 CdN 12 O 4 ) n .

[0036] Add 0.5g of phenol to the container, add 15ml of water as solvent, stir and add 10mg of fluconazole cadmium coordination polymer (as catalyst), and when heated to 60℃ under stirring, add H 2 O 2 (30%) 0.5ml started timing, and the reaction was stopped after 1 hour, and there was almost no conversion of phenol.

Example Embodiment

[0037] Example 3:

[0038] The methanol solution of 15ml fluconazole (0.02mmol.ml -1 ) Add dropwise to 3mlCuCl 2 ·2H 2 O aqueous solution (0.05mmol.ml -1 ), shake well and stand still at room temperature. After 3 days, a blue single crystal appears to obtain fluconazole copper coordination polymer with a yield of 77%. X-single crystal diffractometer analysis and characterization, it is a coordination polymer with a two-dimensional network structure, the molecular formula is (C 28 H 32 Cl 2 F 4 CuN 12 O 4 ) n .

[0039] Add 0.5g of phenol into the container, add 15ml of water as solvent, stir and add 15mg of fluconazole copper coordination polymer (as catalyst), and when heated to 50℃ under stirring, add H 2 O 2 (30%) 0.5ml starts timing, and stops the reaction after 1 hour. The reaction product was separated by filtration, and the reaction product was detected by high performance liquid chromatography. The result: the conversion rate of phenol was 78%, the content of catechol in t...

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Abstract

A fluorofurfurlazole cooling polymer used as the catalyst for preparing pyrocatechol by the hydroxylation reaction between phenol and H2O2 with high selectivity is prepared from fluorofurfurylazole and the chloride of transition metal through self assembling and culturing.

Description

Technical field: [0001] The invention relates to a coordination polymer produced by a nitrogen-containing ligand and a transition metal, a preparation method and an application thereof. Background technique: [0002] In recent years, the research of supramolecular chemistry has developed rapidly, and the construction of supramolecules by crystal engineering is one of the main goals of supramolecular chemistry research, especially the coordination polymers with topological structure, which have received unprecedented attention. Coordination polymers are formed through the self-assembly of transition metals and organic ligands under mild conditions. They combine the characteristics of composite polymers and coordination compounds, and have many forms such as chains, grids, trapezoids, and cages. Coordination polymers with this structure have been synthesized. Because of their structural diversity, they exhibit unique properties and have broad application prospects in nonlinear...

Claims

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Application Information

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IPC IPC(8): B01J31/16C07C37/60C07C39/08C07F1/08C07F15/00C08G83/00
Inventor 侯红卫韩华云樊耀亭孟祥茹牛云垠
Owner ZHENGZHOU UNIV
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