Artificial skin prepared from purely natural materials and having gradient hole structure and property

Abstract

The invention relates to artificial skin prepared from purely natural materials and having gradient hole structure and property and a preparation method thereof. The artificial skin comprises an epidermal layer and an enderonic layer, wherein the epidermal layer and the enderonic layer both have the gradient in the structure and the property simultaneously and the thicknesses of the epidermal layer and the enderonic layer are between 0.5 millimeters and 1.5 millimeters and can be regulated as required; the epidermal layer is a thin film which has the functions of water prevention, air permeation and enderon protection and has compacter structure, and the dimensions of holes are smaller than 5 micrometers; the epidermal layer has degradability, degrading period between four months and six months and good elasticity and ductility; the enderonic layer of the artificial skin is prepared from collagen and polysaccharide in a simulating way, in a sponge shape, porous and mutually communicated, the dimensions and the distribution of the holes are in gradient distribution from top to bottom, and apertures are increased from 20 micrometers to 300 micrometers; the enderonic layer has different degrading periods from top to bottom and is also in the gradient distribution, degrading speed is increased from top to bottom, and the degrading periods are accelerated from four months to two weeks; and the dimensions and the distribution of the holes and the gradient of degradation are controlled by the component transformation and a multi-layer overlying processing technology.

Description

technical field

[0001] The invention belongs to the field of medical equipment. More precisely, the present invention relates to an artificial skin bionically prepared from pure natural raw materials. technical background

[0002] The skin covers the surface of the human body and is in direct contact with the external environment, which not only protects the human body from the invasion of dirt or bacteria, but also keeps the moisture in the human body from escaping. As an important tissue and organ covering and protecting the body surface, the skin is very vulnerable to defects caused by factors such as external damage and disease. When a large area of ​​skin is severely burned or damaged, the damage can be fatal, and the skin cannot repair itself, and superficial skin from other parts of the body is usually grafted onto the wound.

[0003] Since there is no alternative source of skin, autologous skin grafting is often used in treatment, that is, doctors need to remove a ...