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Artificial skin prepared from purely natural materials and having gradient hole structure and property

An artificial skin and gradient technology, applied in the field of artificial skin, can solve problems such as easy injury and infection, and achieve the effect of promoting wound healing, good waterproofness and good air permeability

Active Publication Date: 2010-06-02
SHENZHEN QIKANG MEDICAL DEVICES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cells of the epidermis are closely connected to each other, so they serve a defensive function against external stimuli, but are also vulnerable to injury and infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Silk fibroin / chitosan skin layer preparation steps are:

[0050] (1), prepare the silk fibroin / chitosan mixed solution, the concentration of the two in the mixed solution is 4% and 0.5% respectively.

[0051] (2) Spray the silk fibroin / chitosan solution on the template, after gradient drying, the temperature gradient ranges from 50 to 80°C, pressurize, and prepare a uniform silk fibroin / chitosan film, which is dense , the size of the pores is less than 5 microns.

[0052] (3) Appropriately pressurize the above-mentioned film under the condition of 80-100° C., then rapidly cool down, repeat several times, and finally solidify with alcohol solution. The prepared epidermis is degradable, the degradation period of the epidermis is between 1 and 2 months, and it also has good elasticity and ductility.

[0053] The steps of continuous processing on the superficial layer to prepare the dermis are as follows:

[0054] (4) Prepare a mixed solution of collagen and hyaluronic aci...

Embodiment 2

[0057] Silk fibroin / chitosan skin layer preparation steps are:

[0058] (1), prepare silk fibroin / chitosan mixed solution, the concentration of the two in mixed solution is respectively 50% and 20%,

[0059] (2) Spray the silk fibroin / chitosan solution on the template, after gradient drying, the temperature gradient ranges from 50 to 80°C, pressurize, and prepare a uniform silk fibroin / chitosan film, which is dense , the size of the pores is less than 5 microns.

[0060] (3) Appropriately pressurize the above-mentioned film under the condition of 80-100° C., then rapidly cool down, repeat several times, and finally solidify with alcohol solution. The prepared epidermis is degradable, the degradation period of the epidermis is between 1 and 2 months, and it also has good elasticity and ductility.

[0061] The steps of continuous processing on the superficial layer to prepare the dermis are as follows:

[0062] (4) Prepare a mixed solution of collagen and hyaluronic acid with...

Embodiment 3

[0065] Silk fibroin / chitosan skin layer preparation steps are:

[0066] (1), prepare silk fibroin / chitosan mixed solution, the concentration of the two in mixed solution is respectively 0.5% and 0.1%,

[0067] (2) Spray the silk fibroin / chitosan solution on the template, after gradient drying, the temperature gradient ranges from 50 to 80°C, pressurize, and prepare a uniform silk fibroin / chitosan film, which is dense , the size of the pores is less than 5 microns.

[0068] (3) Appropriately pressurize the above-mentioned film under the condition of 80-100° C., then rapidly cool down, repeat several times, and finally solidify with alcohol solution. The prepared epidermis is degradable, the degradation period of the epidermis is between 1 and 2 months, and it also has good elasticity and ductility.

[0069] The steps of continuous processing on the superficial layer to prepare the dermis are as follows:

[0070] (6) Prepare a mixed solution of collagen and hyaluronic acid wi...

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Abstract

The invention relates to artificial skin prepared from purely natural materials and having gradient hole structure and property and a preparation method thereof. The artificial skin comprises an epidermal layer and an enderonic layer, wherein the epidermal layer and the enderonic layer both have the gradient in the structure and the property simultaneously and the thicknesses of the epidermal layer and the enderonic layer are between 0.5 millimeters and 1.5 millimeters and can be regulated as required; the epidermal layer is a thin film which has the functions of water prevention, air permeation and enderon protection and has compacter structure, and the dimensions of holes are smaller than 5 micrometers; the epidermal layer has degradability, degrading period between four months and six months and good elasticity and ductility; the enderonic layer of the artificial skin is prepared from collagen and polysaccharide in a simulating way, in a sponge shape, porous and mutually communicated, the dimensions and the distribution of the holes are in gradient distribution from top to bottom, and apertures are increased from 20 micrometers to 300 micrometers; the enderonic layer has different degrading periods from top to bottom and is also in the gradient distribution, degrading speed is increased from top to bottom, and the degrading periods are accelerated from four months to two weeks; and the dimensions and the distribution of the holes and the gradient of degradation are controlled by the component transformation and a multi-layer overlying processing technology.

Description

technical field [0001] The invention belongs to the field of medical equipment. More precisely, the present invention relates to an artificial skin bionically prepared from pure natural raw materials. technical background [0002] The skin covers the surface of the human body and is in direct contact with the external environment, which not only protects the human body from the invasion of dirt or bacteria, but also keeps the moisture in the human body from escaping. As an important tissue and organ covering and protecting the body surface, the skin is very vulnerable to defects caused by factors such as external damage and disease. When a large area of ​​skin is severely burned or damaged, the damage can be fatal, and the skin cannot repair itself, and superficial skin from other parts of the body is usually grafted onto the wound. [0003] Since there is no alternative source of skin, autologous skin grafting is often used in treatment, that is, doctors need to remove a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/60A61L27/56A61F2/10
Inventor 佘振定谭荣伟王明波
Owner SHENZHEN QIKANG MEDICAL DEVICES
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