Biopolymer nano tunica fibrosa material capable of being biological degraded and absorbed, preparing method and uses of the same

A biopolymer and nanofiber membrane technology, applied in fiber processing, textiles, papermaking, catheters, etc., can solve problems such as serious fiber adhesion and uneven fiber thickness

Inactive Publication Date: 2008-05-07
INST OF CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the thickness of the fibers reported in this paper is uneven, most of them are between 1 and 15 microns, and the adhesion between the fibers is serious, forming a dendritic structure.

Method used

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  • Biopolymer nano tunica fibrosa material capable of being biological degraded and absorbed, preparing method and uses of the same
  • Biopolymer nano tunica fibrosa material capable of being biological degraded and absorbed, preparing method and uses of the same
  • Biopolymer nano tunica fibrosa material capable of being biological degraded and absorbed, preparing method and uses of the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] See figure 1 . The high-voltage power supply 2 adopts a negative DC high-voltage output power supply, and the maximum output voltage is 40kV. The high-voltage power supply is connected to the injection end of the spinneret 5 of the syringe 1 through wires; the output mode of the syringe pump 4 adopts output pumps with various output frequencies to drive the syringe. Feeding, the maximum output range is 300 microliters per minute, the syringe pump is connected to the feed end of the spinneret of syringe 1 through a catheter; the material of the spinneret is stainless steel, and the diameter of the spinneret is 0.8mm; the collection device is copper wire parallel Arranged rotating drums 3, the diameter of the drums 3 is 80mm, and the distance between the copper wires is 7.5mm; the electrospinning environment temperature control device adopts infrared lamp heating method, the system is PID control, and the control accuracy is within the range of ±3°C.

[0062] (1) Prepara...

Embodiment 2

[0067] The equipment is the same as in Example 1.

[0068] (1) Preparation of solution: preparation concentration is the ionic liquid 1-allyl of the cellulose of 10wt%, 3-methyl imidazolium acetate solution 10ml, wherein cellulose is the wood pulp cellulose that the degree of polymerization is 800, in above-mentioned An organic solvent dimethylformamide is added to the solution, wherein the mass ratio of dimethylformamide / cellulose solution is 2 / 1, stirred evenly, and placed in a syringe;

[0069] (2) Adjust the electrospinning device: select a single spinneret device, and the rotating drum is used as a collector; adjust the distance between the spinneret and the collecting device to be 15cm; the ambient temperature of spinning is 45 degrees, and the air velocity in the environment Controlled at 0.5~0.8m 3 / hr;

[0070] (3) Set the spinning process parameters: turn on the high-voltage power supply, adjust the voltage to 18KV, the feeding speed of the solution is 60ul / min, th...

Embodiment 3

[0073] The equipment is the same as in Example 1, and the collection device is changed to a rotating drum with copper wires arranged crosswise.

[0074] (1) Preparation of solution: preparation concentration is the ionic liquid 1-allyl of the cellulose of 10wt%, 3-methylclomidazolium salt solution 5ml, wherein cellulose is the wood pulp cellulose that the degree of polymerization is 800, in above-mentioned Add organic solvent dimethyl sulfoxide to the solution, wherein the mass ratio of dimethyl sulfoxide / cellulose solution is 2 / 1, stir evenly, and place in a syringe;

[0075] (2) Adjust the electrospinning device: select a single spinneret device, and the rotating drum is used as a collector; adjust the distance between the spinneret and the collecting device to be 15cm; the ambient temperature of spinning is 25 degrees, and the air velocity in the environment Controlled at 0.5~0.8m 3 / hr;

[0076] (3) Set the spinning process parameters: turn on the high-voltage power supp...

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Abstract

The invention relates to compound millimicron fibrous membrane material of cellulose and cellulose matrix which can perform the biological degradation and the biological absorption and a preparation method thereof and an industry and medical purpose, and belongs to the biological macro-molecule non woven fabric material field which can perform the biological degradation and the biological absorption. Electrostatic spinning equipment is used to obtain the fibrous membrane material which can perform the biological degradation and the biological absorption, the weight of the cellulose is taken as basic reference, the component of the material comprises cellulose more than 0 and less than or equal to 100 weight parts, other biomacromolecule more than and equal to 0 and less than 100 weight parts, 0 to 10 weight parts of curative drug or 0 to 50 weight parts of inorganic catalyzer and / or 0 to 50 weight parts of inorganic strengthening agent. The material of the invention has good biological compatibility, biological degradation property and degradation absorptivity, and can be used for haemostasia material, wound cladding material, organization engineering supporting rack material, the transportation and release of medicine, artificial skin and blood vessel, and postoperation anti blocking material, beauty material and catalyzer carrier, filtering membrane and radiation protection material and so on.

Description

technical field [0001] The invention belongs to the field of biodegradable and bioabsorbable biopolymer non-woven materials, in particular to biodegradable and bioabsorbable cellulose and cellulose-based nanofiber membrane materials and their preparation methods and industrial and medical applications. Background technique [0002] Cellulose is a cheap and easy-to-obtain renewable resource that widely exists in various living and non-living organisms in nature. Wood, cotton, filter paper, etc. all contain a large amount of cellulose, and cellulose is also the basic component of plant cells. It exists in all plants and is one of the most abundant renewable organic resources in the plant kingdom, so it has good biocompatibility and is a natural biodegradable and bioabsorbable resource. Unmodified cellulose is insoluble in water, dilute acid or dilute alkali, and insoluble in general organic solvents due to the strong hydrogen bonds between molecules and molecules, so it has ex...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L27/48A61L27/44A61L29/12A61L31/12D01D5/00
Inventor 韩志超贺爱华许杉杉李军星
Owner INST OF CHEM CHINESE ACAD OF SCI
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