Porous active artificial bone and preparation method thereof

An artificial bone and active technology, applied in the field of preparation of porous active artificial bone, can solve the problems of low mechanical strength, lack of radial pores and porous structure, unfavorable growth of osteoblasts, circulation of body fluid and vascularization, etc. Effects of high mechanical strength, versatility, good osteoconductivity and biocompatibility

Active Publication Date: 2013-07-03
SHENZHEN LANDO BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main technical problem solved by the present invention is to provide a porous active artificial bone material and its preparation method, so as to solve the problem that the bone repair material in the prior art does not have radial channels and porous structure, and its mechanical strength is low, which is not conducive to the formation of osteoblasts. Growth, fluid circulation, and vascularization problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0060] The artificial bone in this example is a kind of drug-loaded artificial bone with small holes, dense parts and directional hole channels. Radial channels for cell nutrients, metabolites, and body fluids. Among them, the dense layer wall thickness of artificial bone is about 100~300μm, the pore size is 200~600μm, the porosity is 30~70%, the radial channel diameter is 40~70μm, the compressive strength is 10~20MPa, and the composition is super Pure β-TCP, its phase content exceeds 99%. The concentration of loaded alendronate sodium is 0.1-10 μg / ml, and the actual drug loading is determined by the ultraviolet spectrophotometer test.

[0061] The preparation process of the artificial bone of the present embodiment comprises the following steps:

[0062] Step 1: preparing calcium phosphate precursor powder;

[0063] Step 2: Prepare a ceramic body in a mold from the pore-forming medium and the precursor powder;

[0064] Step 3: high temperature sintering;

[0065] Step 4:...

Embodiment 2

[0082] The artificial bone in this example is an artificial bone with small holes, dense parts and directional hole channels. The main component is calcium phosphate-based bioceramic material, including dense parts and small holes appearing alternately, and radially designed to facilitate the delivery of cell nutrition. The radial channels of fluid, metabolites, and body fluids are then loaded with two bisphosphonates. Among them, the dense layer wall thickness of artificial bone is about 100~200μm, the pore size is 200~400μm, the porosity is 50~70%, the radial channel diameter is 40~60μm, the compressive strength is 10~20MPa, and the composition is β-TCP And HA, in which the phase β-TCP content is about 80%, and the HA content is about 20%. The concentration of the mixed solution of alendronate sodium and risedronate sodium is 2-8 μg / ml.

[0083] The preparation process of the artificial bone of the present embodiment comprises the following steps:

[0084] Step 1: preparin...

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Abstract

The invention relates to a porous active artificial bone. In the porous active artificial bone, a calcium phosphate-based biological ceramic material is used as a matrix, and the porous active artificial bone comprises small pores, dense parts and directional pore channels and chelates with diphosphonate. A preparation method of the porous active artificial bone comprises the steps of preparing calcium phosphate precursor powder, compression molding a ceramic blank by using a pore-foaming agent, polyester fiber and the precursor powder, high temperature sintering into a calcium phosphate-based ceramic sintered body and forming the dense parts, the small pores distributed alternately; and immersing calcium phosphate-based ceramic sintered body in a diphosphonate solution to chelate with the diphosphonate so as to obtain the drug-loaded porous active artificial bone. The artificial bone provided by the invention has longitudinal directional pores and a porous structure suitable for osteoblast migration, propagation and growth metabolism, can slowly release small molecular drugs capable of promoting the growth of the osteoblast and inhibiting osteoclast, and is particularly suitable for the fields of treating bone defects of osteoporosis patients, dental restoration, and the like.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to a preparation method of a porous active artificial bone with radial channels. Background technique [0002] In the modern medical field, the repair of bone defects caused by trauma, infection, tumor resection and osteomyelitis has always been one of the difficult problems in the field of plastic surgery and orthopedics. [0003] At present, artificial bone or bone particle materials are commonly used to fill small-sized defects, but for large-scale bone defects, autologous bone or allogeneic bone is often used to transplant the defect in the patient's body. The reason why artificial bone is rarely used clinically Large-sized bone defects are mainly due to the fact that it is difficult to meet the requirements in terms of mechanical properties and pore structure, and the repair effect of artificial bone is still slightly inferior to that of autologous bone. [0004] Cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/56A61L27/54
Inventor 佘振定
Owner SHENZHEN LANDO BIOMATERIALS
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