Automatic dilution split charging instrument of radionuclide liquid medicine and dilution split charging method thereof

Abstract

The invention discloses radioactive nuclide liquid medicine automatic dilution diluting and dividing system and the diluting and dividing method, which belongs to the radiopharmaceutical drug application field. The structure comprises a PLC controller, a peristaltic pump, a pneumatic control device, a product bottle, an activity meter measurement barrel and diluting and dividing pipelines. The peristaltic pump, the pneumatic control device and the activity meter measurement barrel are separately connected with the PLC controller by electricity; the product bottle is arranged in the activity meter measurement barrel and the diluting and dividing pipelines are connected with the pneumatic control device. The diluting and dividing system works under the control of the procedures, which can not only ensure the correctness and the diluting and dividing accuracy but also have good protection. The invention is characterized by reasonable design, easy manufacture, flexible and convenient operation, good protective performance, high diluting and dividing accuracy and good repetitiveness.

Description

technical field [0001] The invention relates to the application field of radiopharmaceuticals, in particular to an automatic dilution and packaging apparatus for radionuclide liquid medicine and a dilution and packaging method thereof. Background technique [0002] At present, the radiopharmaceuticals needed by PET centers at home and abroad, such as choline [C-11]-HOLINE, 2-[F-18]-fluoro-2-deoxyglucose (FDG), etc., are all produced by cyclotrons, and the finished drugs are finally It is stored in a sterile vial for use. From the end of production to the next 9 hours, the staff need to manually extract a certain dose of radiopharmaceuticals each time and inject them into the examinee. The dose varies from 5 to 15mci. The dose size required for inspection is relatively strict. There are three disadvantages in manual extraction: one is that the predetermined amount cannot be accurately extracted, and the other is poor repeatability. The syringe cannot extract a suitable volume...

AI Technical Summary

Problems solved by technology

The dose size required for inspection is relatively strict. There are three disadvantages in manual extraction: one is that the predetermined amount cannot be accurately extracted, and the other is poor repeatability. The syringe cannot extract a suitable volume of liquid medicine every time. Quickly and accurately extract a predetermined single dose from a vial with a volume of about 350-1200mci. It is also necessary to put the extracted drug into an activity meter (an instrument for measuring the radioactivity of nuclides) to measure the dose of this extraction. If not When the predetermined value is reached, it must be extracted again, which makes the staff accept too much radiation; the third is that it is inconvenient to dilute, especially when the drug has just been produced, the specific activity is very high. If it is not diluted, when the liquid medicine dispensed into the syringe When the volume is small, the residual activity in the syringe after the injection to the patient is very high, and the actual amount of medicine injected into the human body is reduced

The inaccuracy, poor repeatability and exposure to too much radiation of manual dispensing are the three main defects of traditional dispensing methods

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