Preparation method for extracting flavone from purslane and uses thereof

A technology of purslane and flavonoids is applied in the field of medicine to achieve the effects of lowering blood lipids, lowering the level of lipid peroxides, and having a wide range of raw material sources.

Inactive Publication Date: 2009-04-08
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, after searching, so far, there is no report of purslane extract resisting cisplatin-induced kidney injury.

Method used

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  • Preparation method for extracting flavone from purslane and uses thereof
  • Preparation method for extracting flavone from purslane and uses thereof

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0042] One, a kind of flow process that extracts total flavonoids from purslane is:

[0043] Fresh purslane processing → reflux extraction → suction filtration → supernatant → concentration → purification

[0044] Specific steps are as follows:

[0045] 1. Wash the fresh purslane with clean water, remove its leaves and roots, drain the water and hang it in a dark and ventilated place until the surface moisture is completely removed. The time is controlled at 20 or 21 or 22 or 23 or 24 hours.

[0046] 2. Cut the dried purslane stems into 0.8 or 0.9 or 1 or 1.1 or 1.2 cm short sticks.

[0047]3. Add 6 times the volume of 70% ethanol (mass ratio) to the purslane, reflux in a water bath at 78 or 79 or 80 or 81 or 82°C for 1 or 2 or 3 hours, and reflux for 4 or 3 or 2 times.

[0048] 4. Suction filter the solution obtained after reflux, leave the filtrate, discard impurities, and then mix the liquid obtained by reflux and suction filtration three times.

[0049] 5. Temperature ...

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Abstract

The invention discloses a preparation method for extracting flavone from purslane and application thereof. The medicine is characterized by a purslane alcohol extract. The preparation method comprises the following steps: 1. cleaning and drying the purslane; 2. cutting the purslane into short sticks; 3. extracting the flavone in the purslane by the reflux of alcohol; 4. performing the pumping filtration on the extracting solution; and 5. concentrating the liquid obtained after pumping filtration. The application method of the extract comprises the following steps: 1. inoculating tumor cells; 2. randomly dividing mice into four groups; 3. performing the group treatment; 4. sampling the blood, and weighing tumor; 5. obtaining blood serum; 6. measuring the content of blood urea nitrogen; and 7. measuring the content of serum creatinine. Animal tests prove that the extract can effectively resist kidney damage caused by the anticancer drug cisplatin; moreover, the extract has the advantages of convenient drug application, good effect and no toxic and side effects; and the purslane is wide in source, and low in price, so that the extract also has the advantages of low price and good quality.

Description

technical field [0001] The invention relates to the technical field of medicine, more specifically to a preparation method for extracting total flavonoids from purslane, and also relates to the application of total flavonoids from purslane. Background technique [0002] 1. Antineoplastic drugs can easily cause kidney damage [0003] Although the application of antitumor drugs is of great help to the control of tumors, its damage to the kidneys is a problem that cannot be ignored. The mechanism of antineoplastic drugs on kidney damage is as follows: [0004] First of all, the concentration of the original urine makes the drug concentration in the urine much higher than the blood drug concentration, which is easy to produce crystals and block the renal tubules. At the same time, the weight of the kidneys accounts for only 0.4% of the body weight, while the blood flow accounts for about 25% of the cardiac blood volume. Therefore, when antineoplastic drugs and their metabolit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P13/12
Inventor 杨静郑茗丹胡敏郑永法孙慧英
Owner WUHAN UNIV
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