18 results about "Solid organ" patented technology

The present invention relates to a product derived from allogeneically cultured postnatal thymus tissue for use in a method of inducing thymopoiesis and thereby promoting donor-specific tolerance to an allogeneic solid organ transplant in a recipient requiring a solid organ transplant, such as a heart, lung, liver, or other solid organ or part of a whole solid organ. The product derived from allogeneically cultured postnatal thymus tissue is prepared by subjecting suitable thymus tissue to a conditioning regimen, said conditioning regimen comprising the aseptic processing of the donor thymus tissue in a thymus organ medium and producing sections of donor thymus tissue partially devoid of T cells. The method of preparing the allogeneically cultured postnatal thymus tissue is further disclosed.

This invention provides a pharmaceutical composition for use in a method of preventing antibody-mediated rejection (ABMR) in subjects who have undergone solid organ transplantation by preventing complement activity. [Solution] A pharmaceutical composition comprising an anti-human interleukin-6 (IL-6) antibody or an anti-human IL-6 antibody fragment for use in a method of preventing, stabilizing, or reducing complement activity in a subject who is scheduled to receive, has received, or has received a solid organ transplant, wherein the method comprises administering to a subject a prophylactic or therapeutically effective amount of the antibody or antibody fragment, the pharmaceutical composition comprising a variable light chain polypeptide containing a CDR of a specific sequence, and a variable heavy chain polypeptide containing a CDR of a specific sequence.

The present disclosure provides a Paenibacillus strain, and a hemostatic polysaccharide produced by same and use thereof. In the present disclosure, a Paenibacillus sp. 1229 has a deposit number of CCTCC NO: M 2022553. A produced exopolysaccharide (EPS) Hemoadhican has a hemostatic function, and can be prepared as a hemostatic material in different dosage forms for different types of hemostasis. The hemostatic material has a high hemostatic speed, no need for applying pressures to the wound for a long time, safety and non-toxicity, desirable biocompatibility, and no requirement of removal after use. The material is suitable for the application of hemostasis in irregular bleeding such as solid organs in vitro or in vivo and diffuse bleeding.

B-cell maturation antigen (BCMA) is expressed on plasma cells. The present invention provides methods for desensitizing patients in need of a solid organ transplant to anti-HLA antibodies using bispecific antibodies that bind to both BCMA and CD3 and activate T cells via the CD3 complex in the presence of BCMA-expressing plasma cells. In certain embodiments, the bispecific antibodies of the present invention reduce alloantibody levels and / or reduce calculated panel reactive antibody levels to facilitate solid organ transplantation and / or improve long term graft survival and / or function.

The present invention relates to drugs, dosage regimens, dosing intervals, and methods of administration for treating antibody-mediated rejection using an effective amount of a drug targeting Blys and / or APRIL. The result shows that the provided effective dose of the drug targeting Blys and / or APRIL shows good safety and treatment effect in the process of preventing, treating or relieving antibody-mediated rejection in patients who are about to accept, are receiving or have accepted entity organ transplantation.

1. The name of the design product: navigation trolley (second generation of puncture surgery navigation positioning system). 2. The use of the design product: navigation positioning for puncture surgery of solid organs such as lung and abdomen of patients. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view 1. 5. Other circumstances that need to be explained: the design to be protected does not contain color.

The invention relates to a system (1) for performing an image-guided surgical operation or intervention, comprising at least one preparatory medical imaging device (3). This system is particular in that it comprises: - a module for generating a 3D model (4) of a solid organ (2), - a module for generating a database (8) of synthetic ultrasound signals and / or images generated from said 3D model, simulating acquisitions of ultrasound signals and / or images corresponding to sections of said organ (2) according to several positions and orientations of an ultrasound probe, - at least one main ultrasound probe (9), - a processing module (11) configured to take as input a signal or image corresponding to a section of said organ (2), and to determine in real time the position of the section of the organ (2) corresponding to this signal or image in the 3D model. Figure for the abstract: Fig 4

The invention belongs to the technical field of biomedicine, and particularly relates to application of CD69 + CXCR6 + gamma delta T cells in preparation of a medicine for preventing and / or treating hepatic fibrosis. It is revealed for the first time that the liver resident memory T cell CD69 + CXCR6 + gamma delta T cell subset can kill the HSCs, secretion of Th1 type cytokines IL-2, IFN-gamma and the like is promoted, fibrosis liver can be precisely targeted according to the natural homing characteristic, the survival time of cells after reinfusion and formation of the memory T cells are prolonged, and by inhibiting activation of the HSCs, the effect of killing the HSCs is achieved. The effect of inducing apoptosis to reverse hepatic fibrosis is achieved, and the technical defect that a traditional CAR-T therapy is insufficient in targeting in solid organ diseases is overcome.

Compositions and methods of transplanting cells by grafting strategies into solid organs (especially internal organs) are provided. These methods and compositions can be used to repair diseased organs or to establish models of disease states in experimental hosts. The method involves attachment onto the surface of a tissue or organ, a patch graft, a “bandaid-like” covering, containing epithelial cells with supporting early lineage stage mesenchymal cells. The cells are incorporated into soft gel-forming biomaterials prepared under serum-free, defined conditions comprised of nutrients, lipids, vitamins, and regulatory signals that collectively support stemness of the donor cells. The graft is covered with a biodegradable, biocompatible, bioresorbable backing used to affix the graft to the target site. The cells in the graft migrate into and throughout the tissue such that within a couple of weeks they are uniformly dispersed within the recipient (host) tissue. The mechanisms by which engraftment and integration of donor cells into the organ or tissue involve multiple membrane-associated and secreted forms of MMPs.

The invention relates to a system (1) for implementing a surgical operation or procedure guided by imaging, the system comprising at least one preparatory medical imaging device (3). This system is characterised in that it comprises: - a module for generating a 3D model (4) of a solid organ (2); - a module (7) for generating a database (8) of synthetic ultrasound images and / or signals generated from the 3D model, the images and / or signals simulating acquisitions of ultrasound images and / or signals corresponding to sections of the organ (2) according to a plurality of positions and orientations of an ultrasound probe; - at least one main ultrasound probe (9); - a processing module (11) configured to receive as input a signal or image corresponding to a section of the organ (2) and to determine, in real time, the position of the section of the organ (2) corresponding to this signal or image in the 3D model.

Provided herein are immunogenic polypeptides, compositions, and methods related to the development of CMV-specific prophylactic and / or therapeutic immunotherapies based on cytotoxic T cell (CTL)-recognized T cell epitopes (e.g., CMV epitopes), and can be used to prevent and / or treat CMV infection, reactivation, and / or disease (e.g., CMV-associated end-organ disease), especially in solid organ transplant recipients.

The invention relates to biomarker signatures for stratifying the graft function and / or infection status of a solid organ transplant recipient, methods of using the same and kits for the detection thereof. In particular, the present invention relates to biomarker signatures for stratifying Chronic Lung Allograft Dysfunction (CLAD) and / or infection status of a lung transplant recipient.

Provided herein are methods for the treatment or prevention of solid organ transplant rejection in a subject in need thereof, comprising administering to the subject a multispecific binding proteins comprising (a) a first antigen binding domain (ABD) comprising an immunoglobulin single variable domain (ISVD) (e.g., VHH) with binding specificity to CD28; and (b) a second ABD comprising an immunoglobulin heavy chain variable domain (VH) and an immunoglobulin light chain variable domain (VL) with binding specificity to OX40.

The present invention relates to methods for monitoring potential indications of allogeneic organ rejection by monitoring transplanted hair follicles from the same donor of a transplanted organ, and for performing or modifying immunosuppressive therapy to ameliorate or prevent the occurrence of acute or chronic organ rejection. The methods of the invention may also be used to select candidate allogeneic solid organ donors for recipients, as well as to improve the occurrence of acute rejection of transplanted allogeneic solid organs, such as kidneys.

This invention discloses a method and system for detecting abdominal ultrasound in pets based on image analysis, belonging to the field of pet abdominal ultrasound image processing technology. This method maps the ultrasound image to the complex frequency domain using a two-dimensional fast Fourier transform, extracting the spatial phase spectrum. Using the zero-frequency center point as the origin of the emission point, low-frequency components of the solid organ contours are filtered out. Non-axial radial sampling rays are traversed within a preset high-frequency band, extracting the phase value sequence and calculating the autocorrelation coefficient. The feature direction angle corresponding to the maximum value is retrieved. A two-dimensional Gaussian filter mask is constructed based on this, and it is multiplied element-wise with a two-dimensional complex frequency domain matrix to specifically reduce physical grid stripe noise in that direction. Finally, a two-dimensional inverse Fourier transform is used to restore the image to the spatial domain and reconstruct an edge suppression feature map, which is then input into a machine learning model to output an auxiliary probability report of the lesion. This invention specifically filters out structured physical grid noise caused by residual hair roots in pets, significantly improving the accuracy of lesion identification.

This method for producing a solid organ failure model non-human animal uses a non-human animal having, in the genome, a promoter and a DNA sequence functionally linked to the promoter on the downstream thereof and encoding an inducible caspase. The method is characterized by including: a step for administering a chemical dimerization inducer (CID), which activates the caspase, to a dam of the non-human animal that is carrying a fetus while a target solid organ is being formed; and a step for reducing the number of cells of interest in the solid organ of a post-birth baby animal and inducing organ failure.

Contemplated systems and methods use high-accuracy in silico HLA analysis to so establish a transplant match database suitable for transplantation, and particularly stem cell and solid organ transplant.

1. Name of the design product: mechanical arm trolley (second generation of navigation positioning system for puncture surgery). 2. Use of the design product: navigation positioning for puncture surgery of solid organs such as lung and abdomen of patients. 3. Design points of the design product: in shape. 4. Picture or photo best indicating the design points: perspective view 1.