Preparation method of bionic human bone biologic material

A technology of biomaterials and bionic human beings, applied in the field of preparation of bionic human bone biomaterials, can solve the problems that cannot be widely used, and achieve the effect of good biocompatibility and good biocompatibility

Inactive Publication Date: 2009-08-19
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although there are some preparation methods of bionic human bone materials, they all have some defects and cannot be widely used. Therefore, it is extremely urge...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: 1) First, Micro CT is used to obtain the three-dimensional microstructure data of the human bone that needs to be repaired or replaced. Based on the three-dimensional microstructure data, CAD is used to establish a three-dimensional model of the individualized human bone, and then the three-dimensional model is sliced ​​and layered to obtain The slice data of individual human bone repair or rapid prototyping of substitutes is sintered by the laser selective area direct sintering metal process of rapid prototyping technology according to the slice data, that is, the biometal titanium alloy micropowder Ti of 10-60 μm is used 6 al 7 Nb is used as raw material to directly sinter metal powder by laser to form a bionic microporous scaffold for human bone metal. The forming equipment uses a fiber laser. The process parameters of laser sintering are: laser power P=70W, scanning speed V=35mm / s, scanning distance L=0.2 mm, powder layer thickness H=0.12mm, the whole for...

Embodiment 2

[0017] Example 2: 1) First, use Micro CT to obtain the three-dimensional microstructure data of the human bone in the patient's repaired or replaced part, and use CAD to establish a three-dimensional model of the individualized human bone according to the three-dimensional microstructure data, and then slice and layer the three-dimensional model to obtain The slice data of individual human bone repair or rapid prototyping of substitutes is sintered by the laser selective area direct sintering metal process of rapid prototyping technology according to the slice data, that is, the biometal titanium alloy micropowder Ti of 10-60 μm is used 6 al 4 V is raw material using direct laser sintering metal powder to form human bone metal biomimetic microporous bracket. The forming equipment uses fiber laser. The process parameters of laser sintering are: laser power P=78W, scanning speed V=26mm / s, scanning distance L=0.3 mm, powder layer thickness H=0.08mm, the whole forming process is c...

Embodiment 3

[0020] Example 3: 1) First, use Micro CT to obtain the three-dimensional microstructure data of the human bone in the patient's repaired or replaced part, and use CAD to establish a three-dimensional model of the individualized human bone according to the three-dimensional microstructure data, and then slice and layer the three-dimensional model to obtain The slice data of individual human bone repair or rapid prototyping of substitutes is sintered by the laser selective area direct sintering metal process of rapid prototyping technology according to the slice data, that is, the biometal titanium alloy micropowder Ti of 10-60 μm is used 5 al 2.5 Fe is used as raw material to use direct laser sintering metal powder to form human bone metal bionic microporous scaffold. The forming equipment uses fiber laser. The process parameters of laser sintering are: laser power P=85W, scanning speed V=20mm / s, scanning distance L=0.3 mm, powder layer thickness H=0.15mm, the whole forming pro...

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Abstract

The invention provides a method for preparing a bionic human bone biomaterial. The method comprises the steps of utilizing a direct laser selective sintering technique to prepare a human bone bionic micropore bracket, injecting a material with the function of inducing bone growth into the bionic micropore bracket, drying and curing the obtained product and obtaining the bionic human bone biomaterial. The method combines the advantages of metal biomaterials and non-metal biological ceramic materials (hydroxyapatite), and utilizes the direct laser selective sintering technique, a vacuum impregnation technique and the like to prepare a novel bionic human bone biological composite material. The material has the advantages of biomechanical properties similar to natural bones, good biocompatibility, capability of realizing the synostosis of implanted bones and human tissue after the material is implanted into human bodies, safety and reliability. The bionic human bone biomaterial prepared by the preparation method has ultimate tensile strength more than 300 MPa, elongation between 10 and 12 percent, tension-compression elastic modulus less than 50 GPa and good biocompatibility.

Description

technical field [0001] The invention belongs to the field of biological materials, and in particular relates to a preparation method of a bionic human bone biological material. Background technique [0002] Biomaterials currently used for human bone repair and replacement mainly include metal materials represented by titanium and alloys and bioceramic materials represented by hydroxyapatite. Metal titanium and titanium alloy medical materials are widely used in artificial bones, artificial joints, tooth root materials, etc. due to their high strength, toughness and good process forming. However, titanium metal itself is a biologically inert material in a physiological environment, and it is difficult to form a firm combination with human tissues. Hydroxyapatite has excellent biocompatibility, corrosion resistance and wear resistance, and is easy to form osseointegration with tissues, but its inherent brittleness and fatigue damage in physiological environments limit its wid...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/56A61L27/06A61L27/12
Inventor 党新安杨立军张昌松
Owner SHAANXI UNIV OF SCI & TECH
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