The invention discloses a service life based high-temperature container creep fatigue strength design method. The method comprises the steps of 1, performing structure preliminary design; 2 determining load and temperature conditions and the design service life requirement; 3, determining dangerous sections; 4, calculating the equivalent stress and strain range; 5, calculating reference stress; 6, determining whether plastic collapse occurs; 7 determining whether the plastic ratchet occur; 8, determining whether creep damage is important; 9, estimating fatigue damage of each cycle when the creep damage is not important; 10, determining whether the fatigue damage is important; 11, estimating the creep damage when the fatigue damage is not important; 12, estimating damage of each cycle when the creep damage and the fatigue damage are non-ignorable; 13, estimating creep-fatigue total damage; 14, performing result analysis and structural design improvement; 15, completing structural design. According to the method, the foundation is laid for national establishing of creep and fatigue failure mode based high-temperature pressure container design standards and achieving design and manufacture of high-temperature pressure containers according to the service life.