The invention discloses an integrated optimization method of static strength, rigidity, stability of a wallboard structure. In an optimization design process, apart from conventional static strength and rigidity, an integrated stability determination coefficient of the wallboard structure is introduced as a constraint condition, i.e., in an iteration process, automatic calculation and determination are performed on multiple instability modes including wallboard rib compression stability, pressing damage strength, compression stability of a skin diaphragm structure, cutting stability, integrated wallboard stability and the like, minimization of the total weight of the structure is taken as an object, dimension parameters of the wallboard structure are optimized, under the condition that the static strength, the rigidity and the integrated stability performance of the wallboard structure after the optimization satisfy design requirements, the weight of the structure is the lightest, recalculation on various stability of the structure after conventional engineering design and optimization is avoided, the problems of increased calculation cost and design change risks which are caused by using a conventional method are solved, and the design efficiency is substantially improved.