Method for preparing rhizoma drynariae/pig bone powder/chitosan compound bracket material

A technology of scaffold material and drynaria, applied in scaffolds, medical science, prostheses, etc., can solve problems such as difficulties in processing and forming derived bone, restrictions on the application of heterogeneous bone, and impact on strength, so as to promote bone cell formation ability and improve mechanical strength. performance, pH stabilization effect

Inactive Publication Date: 2010-06-09
JIAMUSI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Heterogeneic bone repair materials have a wide range of sources, are easy to operate, show good osteoconductivity and biocompatibility during transplantation, do not need to open up redundant operations, and have the advantages of less damage to patients. However, heterogeneous bone also has immune rejection and cross-infection of diseases. problems that limit the application of xenografts
Derivatized (decalcified, cryogenically frozen, boiled, gamma-ray irradiated, chemically deproteinized) xenogeneic bone can eliminate antigenicity, and can better maintain the original osteoconduction and even osteoinductivity, which is a good way to expand bone source, but the derived bone is difficult to process and shape, and sometimes the strength will be affected

Method used

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  • Method for preparing rhizoma drynariae/pig bone powder/chitosan compound bracket material
  • Method for preparing rhizoma drynariae/pig bone powder/chitosan compound bracket material
  • Method for preparing rhizoma drynariae/pig bone powder/chitosan compound bracket material

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Embodiment 1

[0056] Embodiment 1: Preparation of Chinese medicine Rhizoma Rhizoma Drynariae (powder) / pork bone powder (porcine bone type hydroxyapatite) / chitosan composite scaffold material (change the content of chitosan)

[0057] Firstly, pig bones are pretreated, degreased, decalcified, calcined, and ball milled to obtain pig bone powder (pork bone type hydroxyapatite), and drynaria rhizome is crushed into small particles, and then ball milled with a planetary ball mill for 3 hours, and then used Grinding in an agate mortar, passing through a 200-mesh sieve and then bagging for subsequent use, followed by the dissolving of chitosan, which is dissolved with 2% acetic acid solution. Then chitosan is modified with chelating type pyrophosphate titanate coupling agent (NDZ-311), and the consumption of chelating type pyrophosphate titanate coupling agent (NDZ-311) is 1wt of chitosan %, after two hours of magnetic stirring, the mixed powder of porcine hydroxyapatite and Drynaria fortunei (cons...

Embodiment 2

[0058] Embodiment 2: Preparation of Chinese medicine Rhizoma Drynariae (powder) / pork bone powder (porcine bone type hydroxyapatite) / chitosan composite scaffold material

[0059] First, chitosan is modified with chelating pyrophosphate titanate coupling agent (NDZ-311), and the consumption of chelating pyrophosphate titanate coupling agent (NDZ-311) is 1wt of chitosan %, after two hours of magnetic stirring, the mixed powder of porcine-type hydroxyapatite and drynaria (consumption is 1 / 10 of the total amount of porcine-type hydroxyapatite and CS) is mixed with porcine-type hydroxyapatite The ratio of CS to 8:2 was poured into the chitosan solution, and after four hours of magnetic stirring, the mixture was evenly stirred with a glass rod to achieve uniform dispersion to obtain a viscous solution. Pour the solution into the mold, then put it in the refrigerator to pre-cool at -85°C for about 24 hours, then put it into a low-temperature freezer immediately after taking it out, an...

Embodiment 3

[0060] Embodiment 3: Preparation of Chinese medicine Rhizoma Drynariae (solvent) / pork bone powder (porcine bone type hydroxyapatite) / chitosan composite scaffold material

[0061] Firstly, pig bones are pretreated, degreased, decalcified, calcined, and ball milled to obtain pig bone powder (pork bone type hydroxyapatite), and drynaria rhizome is crushed into small particles, and then ball milled with a planetary ball mill for 3 hours, and then used Grinding in an agate mortar, passing through a 200-mesh sieve and then bagging for later use, followed by dissolving chitosan. Then chitosan is modified with chelating type pyrophosphate titanate coupling agent (NDZ-311), and the consumption of chelating type pyrophosphate titanate coupling agent (NDZ-311) is 1wt of chitosan %, after two hours of magnetic stirring, porcine-type hydroxyapatite is poured into the chitosan solution in the ratio of 8:2 by porcine-type hydroxyapatite: CS, and then the concentrated solution of drynaria is ...

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Abstract

The invention adopts a method for preparing a medicated tissue engineering bracket material by a fully natural material, which overcomes the defects of slower growth of bone tissues at the initial period of implantation and weak synostosis at the initial period in the traditional tissue engineering bracket. The traditional Chinese medicines of rhizoma drynariae and pig bone type hydroxylapatite are introduced into the bracket to obtain a compound tissue engineering bracket material with excellent biological activity. The pig bone type hydroxylapatite is extracted from pig bones, has excellent biological activity and low production cost, is green and innoxious and is pulverized to reach a micron / nano state; the traditional Chinese medicine of the rhizoma drynariae has the functions of promoting the multiplication of osteoblast, accelerating the bone growth, diminishing inflammation and resisting bacteria and is prepared by an effective water extraction solvent method, a pulverization method and a spraying method; and the chitosan is used as a template and is prepared by a vacuum freeze drying method. The porosity of the bracket material is between 45% and 91%, the aperture is adjustable within a range of 40-500mu m, and the compressive strength can reach 0.1-5.6MPa. In the degradation process, the pH value of the bracket is between 6.77 and 7.50.

Description

Technical field [0001] The invention relates to a method for preparing a drug-containing tissue engineering support material, and the material is an all-natural tissue engineering support material, which is suitable for repairing bone tissue damage and as a bone tissue engineering cell support. Background technique [0002] The homogeneous bone used as a bone repair material has the disadvantages of limited source, limited amount of bone harvested, and the need to open up a second operation area, which brings some pain to the patient. Bone allografts carry the risk of disease transmission and are in limited clinical supply. Synthetic materials have better osteoconductivity and certain mechanical strength, but their osteoconductivity is better, and the inductivity is poor. Due to some technical problems, most of the work on tissue-engineered bone is still in the experimental stage, and it is not easy to carry out. The clinical application still needs to be cautious. Since 1...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/12A61F2/82
Inventor 李慕勤王晶彦王静
Owner JIAMUSI UNIVERSITY
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