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70 results about "Glutarimide" patented technology
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Glutarimide is a chemical compound featuring a piperidine ring with two ketones attached next to the nitrogen. It is a structural component of cycloheximide, a very potent inhibitor of protein synthesis.
Plastic substrates for electronic display applications
Disclosed is the use of certain polyglutarimides as plastic substrates for use in electronic display applications. These substrates have relatively high Tgs for plastics, and good optical clarity and flatness, with low shrinkage and low birefringence. Also disclosed are electronic display cells made using such polyglutarimide substrates.
Owner:ROHM & HAAS CO
Thermoplastic resin composition, resin molded article and polarizer protective film each using the same, and method of producing the resin molded article
InactiveUS20100182689A1Improve heat resistanceProblem arisePolyureas/polyurethane adhesivesPolarising elementsGlutaric anhydrideAcrylic resin
Provided is a resin composition containing a thermoplastic acrylic resin and an ultraviolet absorber (UVA). While this resin composition has excellent heat resistance because of its high glass transition temperature, foaming and bleed-out can be suppressed and the problems arising from the evaporation of the UVA can be reduced even during the molding of the resin composition at a high temperature. The resin composition is a thermoplastic resin composition containing a thermoplastic acrylic resin and an ultraviolet absorber having a molecular weight of 700 or more, and having a glass transition temperature of 110° C. or higher. It is preferable that the ultraviolet absorber has a hydroxyphenyltriazine skeleton. It is preferable that the acrylic resin has a ring structure in its main chain. The ring structure is, for example, at least one selected from a lactone ring structure, a glutaric anhydride structure, a glutarimide structure, an N-substituted maleimide structure, and a maleic anhydride structure.
Owner:NIPPON SHOKUBAI CO LTD
Adhesion binder containing glutarimide moieties
InactiveUS6040025AHigh mechanical strengthSufficient flexibilityHeat exhanger conduitsSynthetic resin layered productsImidePolymer science
The present invention is directed to a multilayer material having in order a layer of fluorinated polymer, a layer of binder for fluorinated polymer having a polymer A with moieties (1)-(4), and a layer of polymer which is incompatible with the fluorinated polymer. The multilayer material is useful for making a pipe which has a superior barrier properties to petroleum products and the additives thereof. The present invention also relates to a pipe having a multilayer structure having two layers of polyamide and a layer of binder comprising a polymer A with glutarimide moieties (1)-(4) in between. The pipe has superior barrier properties to petroleum products and the additives.
Owner:DECUSSA
Acrylic resin film
Disclosed herein is an acrylic resin film having excellent heat resistance and mechanical strength, less fish-eyes, and high transparency. The acrylic resin film is obtained by molding a resin composition containing a glutarimide acrylic resin (G) and a (meth)acrylic resin (F) obtained by polymerization of a vinyl group-containing compound in the presence of alkyl acrylate-based cross-linked elastic particles having an average particle size of less than 80 nm.
Owner:KANEKA CORP
Vehicle part cover including methacrylic-based resin
ActiveUS20150299360A1Improve heat resistanceHigh transparencyVehicle headlampsLighting and heating apparatusGlutaric anhydrideMethacrylate
A vehicle part cover including a methacrylic-based resin (I) having a weight average molecular weight measured by gel permeation chromatography (GPC) of 65,000 to 300,000,the methacrylic-based resin (I) comprising:50 to 97% by mass of a methacrylate monomer unit (A);3 to 30% by mass of a structural unit (B) having a ring structure in its main chain, and being at least one selected from the group consisting of a maleimide-based structural unit, a glutaric anhydride structural unit, a glutarimide-based structural unit, and a lactone ring structural unit; and0 to 20% by mass of another vinyl monomer unit (C) that is copolymerizable with a methacrylate monomer.
Owner:ASAHI KASEI CHEM CORP
Thermoplastic resin composition, molded resin articles and polarizer protecting film made by using thr same, and process for production of the articles
ActiveCN101679710AImprove heat resistanceProblems caused by less evaporationPolyureas/polyurethane adhesivesPolarising elementsTectorial membraneGlutaric anhydride
Owner:NIPPON SHOKUBAI CO LTD
Thermoplastic polymer material for audio and/or optical information recording media
InactiveUS20050013962A1Layered productsIntegrated optical head arrangementsMeth-Ethylene Homopolymers
The invention concerns moulded discs for audio and / or optical information recording media (such as CDS and DVDs) obtained from a thermoplastic polymer material comprising, by weight, (a) 60 to 95%, preferably 70 to 85%, of a thermoplastic resin selected from (1) a methyl methacrylate homopolymer, (2) a copolymer containing in majority units derived from methyl methacrylate monomer, (3) a mixture of the homopolymer (1) and / or of the copolymer (2) with a substituted or unsubstituted styrene copolymer and of at least one monomer selected from (meth)acrylonitrile, maleic anhydride and maleimides or (4) a glutarimide polymer, optionally mixed with a substituted or unsubstituted styrene / (meth)acrylonitrile copolymer and (b) 5 to 40%, preferably 15 to 30%, of at least one impact modifier compound in the form of particles having an average size of between 10 and 200 nm, preferably between 40 and 150 nm.
Owner:ARKEMA FRANCE SA
Novel preparation method of lenalidomide
InactiveCN103601717AProcess raw materials are easy to getShort stepsOrganic chemistryBromineEconomic benefits
The invention discloses a novel preparation method of lenalidomide. Glutarimide and 4-nitro-isoindolin-1-one are used as raw materials of the lenalidomide. The lenalidomide is prepared by (1) performing bromination in the alpha position of the carbonyl of the glutarimide to obtain 3; (2) condensing 4-nitro-isoindolin-1-one and the 3 to obtain 4; and (3) subjecting the 4 to reduction to obtain 5, namely the lenalidomide. The preparation method has easily available raw materials, short steps, simple operation, high reaction yield and low production cost, and is environmental friendly. The preparation method has large implement value and social and economic benefit.
Owner:湖南华腾制药有限公司
Glutarimide Derivatives, Use Thereof, Pharmaceutical Composition Based Thereon and Methods for Producing Glutarimide Derivatives
ActiveUS20160046598A1Same efficiencyBiocideOrganic chemistryRespiratory tract diseaseDicarboxylic acid
The present invention relates to novel biologically active glutarimide derivatives of general formula I or pharmaceutically acceptable salts thereof, their use as an agent for the treatment of upper respiratory tract diseases, pharmaceutical compositions comprising the glutarimide derivatives of general formula I, methods for preparing the glutarimide derivatives of general formula I by heating a dicarboxylic acid monoamide of general formula II with a dehydrating agent.
Owner:OBSCHESTVO S OGRANICHENNOI OTVETABTVENNOSTIYU PHARMENTERPRISES
Radioisotope carbon-14 labelled pesticide chlopyrifos, and synthetic method thereof
ActiveCN108341839ANot easy to loseReduce usageOrganic chemistry methodsGroup 5/15 element organic compoundsChemical synthesisRadioactive tracer
The invention belongs to the field of radiochemical synthesis, and more specifically relates to radioisotope carbon-14 labelled pesticide chlopyrifos, and a synthesis method thereof. The synthesis method comprises following steps: a metal organic reagent is reacted with [14C] carbon dioxide so as to obtain 5-benzyloxy[carbonyl-14C] pentanoic acid; amidation, debenzylation, and cyclization reactionare adopted so as to realize conversion into [carbonyl-2, 6-14C2] glutarimide; aromatization, chlorination, and hydrolysis are adopted, and an obtained hydrolysate and diethyl thiophosphoryl chlorideare subjected to nucleophilic substitution so as to obtain the carbon-14 labelled pesticide chlopyrifos. The synthetic method is capable of avoiding defects in the prior art; the reaction raw materials are easily available; the reaction conditions are mild; production cost is low; the obtained carbon-14 labelled pesticide chlopyrifos can be taken as a radioactive tracer, can be used in tracing ofpollution evolution rules such as migration conversion, metabolism degradation, and absorption enrichment of chlopyrifos in the environment and in vivo, and can be used for providing technical support for comprehensive evaluation of the biological safety of chlopyrifos; and in addition, the synthesis method is capable of providing reference for preparation of building blocks containing C-14.
Owner:ZHEJIANG UNIV
Pregabalin intermediate and process for preparing same
ActiveCN1884263AEasy to separateSimple and fast operationOrganic compound preparationAmino-carboxyl compound preparationGlutaric acidPregabalin
The invention relates to 3-isobutyl glutarimide which is the intermediate of pregabalin treating intermediate and preventing epilepsy, and the method for preparing the same. The method comprises preparation of 3-isobutyl glutarimide by using 3-isobutyl glutaric acid and agent containing nitrogen through cyclocondensation reaction, and preparation of S-(+) - 3- isobutyl gamma- aminobutyric acid through Hoffmann rearrangement and S-amygdalic acid resolution. The method is characterized by simple process, easy separation of intermediate product and end product from reacting dissolvent or recrystallization dissolvent, low cost and suitable for industrial production.
Owner:NHWA PHARMA CORPORATION
Sulfur-containing compound based on glutaryl imide skeleton and application of compound
The present disclosure relates to compound shown in a formula (I) or salts, solvates, isotope-enriched analogs, tautomers, polymorphs, stereoisomers, or mixtures of stereoisomers of the compound, andthe application thereof in the treatment of tumours. The present disclosure also provides tumor treatment application of the compound showed in a formula (I') or pharmaceutically acceptable salts, solvates, isotope-enriched analogs, tautomers, polymorphic substances, stereoisomers, or mixtures of stereoisomers of the compound.
Owner:SHANGHAI TECH UNIV
Application of biosensing test paper based on N, N'-bis (trimethoxy silicyl propyl)-glutarimide
InactiveCN103439482ARealize qualitative analysisGood colorMaterial analysis by observing effect on chemical indicatorBiological testingPaper basedEngineering
The invention discloses the application of biosensing test paper based on N, N'-bis (trimethoxy silicyl propyl)-glutarimide. The biosensing test paper taking N, N'-bis (trimethoxy silicyl propyl)-glutarimide as a color probe is applied to the detection of hydrogen peroxide, glucose or prostate-specific antigen, has special metachromatism to hydrogen peroxide, and has the advantages of high stability and sensitivity, good selectivity; the detection method is fast, simple and economic, and is wide in application range..
Owner:CENT SOUTH UNIV
Ink jet recording head and method for manufacturing the same
InactiveUS7175973B2Forming accuratelyPhotomechanical apparatusOriginals for photomechanical treatmentCarbon numberEngineering
Owner:CANON KK
Amine-linked c3-glutarimide degronimers for target protein degradation
This invention provides amine-linked C3-glutarimide Degronimers and Degrons for therapeutic applications as described further herein, and methods of use and compositions thereof as well as methods fortheir preparation.
Owner:C4 THERAPEUTICS INC
Pharmaceutical composition comprising glutarimide derivatives and use thereof in the treatment of eosinophilic diseases
ActiveUS20160279114A1Suppress eosinophiliaShorten the counting processSenses disorderOrganic chemistryEsophagitisEosinophilic syndrome
The present invention relates to novel biologically active glutarimide derivatives of general formula (I) or a pharmaceutically acceptable salt thereof, their use as a therapeutic agent for the treatment of eosinophilic diseases, preferably of allergic nature, in particular bronchial asthma, allergic rhinitis, polypous rhinosinusopathies, eosinophilic colitis, eosinophilic syndrome, allergic conjunctivitis, atopic dermatitis, Churg-Strauss syndrome, anaphylactic shock, Quincke's edema, eosinophilic vasculitis, eosinophylic esophagitis, eosinophilic gastroenteritis, or fibroses. The invention also relates to pharmaceutical compositions comprising glutarimide derivatives of general formula (I):
Owner:OBSCHESTVO S OGRANICHENNOI OTVETABTVENNOSTIYU PHARMENTERPRISES
Gabapentin preparation method
InactiveCN105061241AReduce or even eliminate the use ofHigh yieldOrganic compound preparationAmino-carboxyl compound preparationGabapentinCyclohexanone
The invention discloses a gabapentin preparation method. The gabapentin preparation method comprises the following steps: (1) placing cyclohexanone and methyl cyanoacetate into a reaction kettle, adding ammonium acetate and methanol, stirring, slowly adding ammonia water into a low-temperature bath for reaction, filtering and then preparing to obtain alpha,alpha'-dicyano-1,1-cyclohexanediacetylimide ammonium salt; (2) adding alpha,alpha'-dicyano-1,1-cyclohexanediacetylimide ammonium salt into high-temperature liquid water in batches to prepare cyclohexanediacetic acid; (3) adding urea into cyclohexanediacetic acid, heating up for reaction, then cooling, and adding the cooled product into an ethanol-water solution to prepare 3,3-pentamethylene glutarimide; (4) dissolving 3,3-pentamethylene glutarimide into a sodium hydroxide water solution, dripping a sodium hypochlorite and sodium hydroxide mixed solution for reaction, dripping hydrochloric acid to adjust the pH to prepare a gabapentin hydrochloride; (5) dissolving the gabapentin hydrochloride into sodium hydroxide to prepare gabapentin. The preparation method has the advantages that the raw materials are easy to obtain, and the yield of the prepared product is high.
Owner:TAICANG YUNTONG BIOCHEM ENG
Polarizing plate and liquid crystal display device
InactiveUS20160349413A1Increased durabilityLight transmittanceAntifouling/underwater paintsPolarising elementsTectorial membraneMeth-
A polarizing plate includes: a polyvinyl alcohol-based polarizer; and transparent protective films provided on both surfaces of the polyvinyl alcohol-based polarizer with an adhesive layer interposed between each of the transparent protective films and the polyvinyl alcohol-based polarizer. A first transparent protective film contains a (meth)acrylic resin and an ultraviolet absorber, the (meth)acrylic resin having an unsaturated carboxylic acid alkyl ester unit and a glutarimide unit represented by the general formula (1), having an imidization ratio of 2.5 to 5.0% and an acid value of 0.10 to 0.50 mmol / g, and having an acrylic ester unit of less than 1% by weight. A second transparent protective film contains a cycloolefin-based resin.R1 and R2 each independently represent hydrogen or an alkyl group; and R3 represents an alkyl group, a cycloalkyl group, or an aryl group.
Owner:NITTO DENKO CORP
Heat-resisting chlorinated polyvinyl chloride material for power cable
InactiveCN106147092AImprove melt fluidityImprove flame retardant performanceAluminium hydroxidePolystyrene
The invention discloses a heat-resistant chlorinated polyvinyl chloride material for power cables. The raw material comprises the following components: chlorinated polyvinyl chloride, polyvinyl chloride, marble, calcium carbonate, calcined kaolin, calcium stearate, stearin Zinc acid, dibutyltin dilaurate, butyl stearate, oxidized polyethylene wax, aluminum hydroxide, magnesium hydroxide, tricresyl phosphate, bis(2‑ethylhexyl)phenyl phosphate, tris(2‑ethylhexyl) phosphate Ethylhexyl) ester, polystyrene, polyglutarimide, stearyl alcohol, silane coupling agent, antioxidant. The heat-resistant chlorinated polyvinyl chloride material for power cables proposed by the invention has high strength, good heat resistance and excellent impact resistance, and the cable material made of the material has good comprehensive performance and long service life.
Owner:安徽华润仪表线缆有限公司
Preparation method of pomalyst pomalidomide
The invention relates to the field of medicine preparation, and particularly relates to a preparation method of pomalyst pomalidomide. The method comprises the following steps: carrying out intramolecular cyclization on N-carbobenzoxy-L-glutamine, so as to generate S-(-)-(2-formamido-phenoxy) glutarimide shown in a formula II; removing carbobenzoxy (CBZ) from the S-(-)-(2-formamido-phenoxy) glutarimide, and then carrying out a salt forming reaction on acid, so as to obtain a salt of S-(-)-2-amino glutaric imide shown in a formula III; carrying out an intermolecular condensation reaction on the salt of the S-(-)-2-amino glutaric imide and 3-nitrophthalicanhydride, so as to obtain 4-nitryl-thalidomide shown in a formula IV; and taking the 4-nitryl-thalidomide to prepare the pomalyst pomalidomide by reduction reaction. The preparation method of the pomalyst pomalidomide, which is provided by the invention, is short in cycle, high in product purity, high in yield, free of pressurized reaction, and more applicable to industrial production, and any individual impurity can be smaller than 0.1% in absence of purification.
Owner:CHONGQING TAIHAO PHARM CO LTD
Resin composition
Disclosed is a resin composition wherein birefringence is controlled. Specifically disclosed is a resin composition essentially containing a resin (A) containing a glutarimide unit and an acrylate unit, and another resin (B) containing a glutarimide unit, an acrylate unit and an aromatic vinyl unit. This resin composition can be easily produced at low cost, and is excellent in transparency and heat resistance. In particular, orientational birefringence can be easily controlled in this resin composition. This resin composition can be used for molded bodies for optical applications which require transparency and heat resistance.
Owner:KANEKA CORP
A process for preparation of polyglutarimide resin using a fluid of super critical condition
Disclosed is a method for preparing a polyglutarimide by reacting an acrylic resin with an imidizing agent. The method uses a supercritical fluid, preferably supercritical carbon dioxide' to remove unreacted materials and by-products, and thus can provide a polyglutarimide having excellent optical properties.
Owner:LG CHEM LTD
Improved process for production of gabapentin intermediate
Owner:TEVA PHARMA IND LTD
Acrylic resin film
Owner:KANEKA CORP
Preparation method of 3,3-pentamethylene glutarimide
The invention discloses a preparation method of 3,3-pentamethylene glutarimide. According to a formula (I), 1,1-cyclohexanediacetic acid mono amide as a raw material, toluene as a solvent and glacial acetic acid as a catalyst undergo a reaction to produce the 3,3-pentamethylene glutarimide as a gabapentin intermediate. The preparation method improves reaction raw material amidation efficiency, a product yield and an output. The preparation method utilizes toluene as the reaction solvent and glacial acetic acid as the catalyst so that reaction efficiency is improved and a product yield is improved. Through recycle of a filtration mother liquor of a main reaction, a production cost is reduced and production benefits are improved.
Owner:JIANGSU RUIDA TECH CO LTD
Polarizing plate and liquid crystal display device
InactiveUS9739910B2Good effectIncreased durabilityAntifouling/underwater paintsPolarising elementsTectorial membraneAcrylic resin
Owner:NITTO DENKO CORP
Resin composition
It is an object of the present invention to provide a resin composition whose birefringence has been controlled. The object can be attained by a resin composition composed essentially of a resin (A) containing glutarimide units and acrylic ester units and a resin (B) containing glutarimide units, acrylic ester units, and aromatic vinyl units. The resin composition of the present invention is easy to manufacture, inexpensive, excellent in terms of transparency and heat resistance, and easily controllable in terms of orientation birefringence. Further, the resin composition of the present invention can be developed to be applied to an optical molding product of which transparency and heat resistance are required.
Owner:KANEKA CORP
Polypeptide, DNA molecule, recombination carrier, transformant, application of polypeptide, application of DNA molecule and application of transformant
The invention discloses polypeptide, a DNA molecule, a recombination carrier, a transformant, an application of the polypeptide, an application of DNA molecule and an application of the transformant,and belongs to the field of a biological technology. In accordance with the problems that in the prior art, in the process of preparing the intermediate ( the intermediate is(R) 3-carbamoymethyl-5-methylhexanoic acid ) of Pregabalin, a large amount of chloroform is needed in a conventional chemical splitting method, so that the environmental pollution is serious, the invention provides the polypeptide. The polypeptide is used, so that 3-Isobutyl glutarimide can be hydrolyzed to obtain the (R) 3-carbamoymethyl-5-methylhexanoic acid which is high in 3-Isobutyl glutarimide and high in yield.
Owner:安徽瑞达健康产业有限公司
Optical resin composition and film
Disclosed herein are an optical resin composition whose orientation birefringence and photoelastic birefringence are both very low and which has high transparency and which provides a film having few surface defects, high heat stability, high solvent resistance, and excellent surface appearance, and a film comprising the optical resin composition.The optical resin composition comprises: a resin (A) having a maleimide unit represented by the formula (5) and a (meth)acrylic ester unit; and a glutarimide acrylic resin (B). The resin composition may further comprise multi-layered particles.
Owner:KANEKA CORP
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