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Sesame polypeptide and extracting method and application thereof in preparation of drugs for resisting oxidization and/or reducing blood pressure

A technology for extracting sesame and protein, which is applied in the field of preparation of anti-oxidant and/or blood pressure-lowering drugs, can solve problems such as waste of resources, backward processing technology, underutilization of sesame protein resources, etc., and achieve high utilization rate of raw materials , easy to absorb by human body, cost controllable effect

Active Publication Date: 2019-08-09
HENAN ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to backward processing technology, sesame protein resources are not fully utilized, resulting in waste of resources

Method used

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  • Sesame polypeptide and extracting method and application thereof in preparation of drugs for resisting oxidization and/or reducing blood pressure
  • Sesame polypeptide and extracting method and application thereof in preparation of drugs for resisting oxidization and/or reducing blood pressure
  • Sesame polypeptide and extracting method and application thereof in preparation of drugs for resisting oxidization and/or reducing blood pressure

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Experimental program
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Effect test

Embodiment 1

[0032] A method for extracting sesame polypeptide from sesame protein, which specifically includes the following steps:

[0033] 1) Sesame protein extraction:

[0034] Take 1 kg of sesame seeds after removing stones, grass seeds and other impurities, crush them to 40 mesh, and use a Soxhlet extractor to degrease. The degreasing conditions are: n-hexane is the extraction agent, the temperature is 70 ° C, and the degreasing is 6 hours. The degreased sesame was added to distilled water at a material-to-liquid ratio (w / v) of 1:15, the pH was adjusted to 7.5, and the protein was extracted by stirring at room temperature for 90 min. After the extraction, centrifuge at 5,000 rpm for 15 min, take the supernatant, and concentrate it with an ultrafiltration membrane with a molecular weight cut-off of 10,000 Da until it is concentrated to 10% of the original volume of the supernatant to stop the concentration, and the concentrated solution is collected as the protein extract. Store at 1...

Embodiment 2

[0041] The invention discloses a method for artificially synthesizing sesame polypeptide, which is artificially synthesized by a chemical solid-phase synthesis method. The basic process is as follows: first, connect an amino acid whose amino group is protected by Fmoc group to the insoluble solid phase carrier Wang resin, and then remove the protecting group of the amino group, and the first amino acid is connected to the solid phase carrier; The carboxyl group of the second amino acid protected by the Fmoc group is activated with a condensing agent, and the activated amino acid reacts with the amino group of the first amino acid that has been attached to the solid phase carrier to form a peptide bond. A dipeptide with a protecting group. Repeat the above-mentioned peptide bond formation reaction to grow the peptide chain from the C-terminal to the N-terminal until the required peptide chain length is reached, and finally cut to obtain the target polypeptide Ser-Tyr-Pro-Thr-Gl...

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Abstract

The invention belongs to the technical field of deep processing of agricultural and sideline products and particularly relates to sesame polypeptide. The polypeptide is composed of nine amino acids, and the sequence of the amino acids is Ser-Tyr-Pro-Thr-Glu-Cys-Arg-Met-Arg. The sesame polypeptide can be artificially synthesized through a chemical solid phase synthesis method, or can also be obtained through enzymolysis of sesame protein, separation and purification. According to the sesame polypeptide, by measuring the DPPH removal ability, the BTS removal ability and the ACE inhibiting ability, it is found that the polypeptide has strong oxidation resisting and strong blood pressure reducing activity, can serve as a functional activity ingredient to be used for preparing drugs, healthcareproducts, food, nutrient enhancers, animal feed and cosmetics daily use chemical supplies and other fields, and has wide market prospects.

Description

technical field [0001] The invention belongs to the technical field of deep processing of agricultural and sideline products, and specifically relates to an active polypeptide SYPTECRMR derived from sesame protein, a preparation method and its application in the preparation of anti-oxidation and / or blood pressure-lowering drugs. Background technique [0002] Studies have confirmed that oxidative stress caused by free radicals can cause more than 200 non-communicable chronic diseases such as blindness, arthritis, Alzheimer's disease, and cardiovascular disease, and seriously endanger human health. In addition, high blood pressure has become a non-communicable chronic disease that seriously endangers the health of Chinese residents. The number of adults with high blood pressure in my country has reached 245 million, and the direct economic burden of high blood pressure accounts for 6.6% of my country's total health expenditure. Therefore, the development of anti-oxidation and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/06C07K1/36C07K1/34C07K1/16C12P21/06A23L33/18A23K20/147A61K38/08A61K8/64A61P39/06A61P9/12A61Q19/00
CPCC07K7/06A23L33/18A23K20/147A61K8/645A61P39/06A61P9/12A61Q19/00A23V2002/00A61K2800/10A61K38/00A23V2200/326A23V2200/30A23V2250/55
Inventor 芦鑫张丽霞贾聪高锦鸿宋国辉孙强黄纪念
Owner HENAN ACAD OF AGRI SCI
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