Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Blood pressure lowering medicine

A technology for lowering blood pressure and drugs, applied in drug combination, cardiovascular system diseases, etc., can solve the problems of unawareness of Rut lowering blood pressure, limited application, and short duration of action.

Inactive Publication Date: 2005-01-26
李元建 +4
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Calcitonin gene-related peptide (CGRP) is the main transmitter of sensory nerves. It is the strongest vasodilation substance known so far. It is a polypeptide that cannot be taken orally, and its half-life is short (about 10 minutes), so its application is limited. Looking for drugs to promote the synthesis and release of endogenous CGRP
[0006] However, the research on the antihypertensive effect of Rut in the prior art only shows that Rut can promote the release of CGRP, and its effect lasts for a short time (only about 2min).
Therefore, according to the prior art, those of ordinary skill do not know whether Rut can be used as a drug for lowering blood pressure

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Blood pressure lowering medicine
  • Blood pressure lowering medicine
  • Blood pressure lowering medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0017] specific implementation plan

[0018] Part 1 The antihypertensive effect and mechanism of single administration of evodiamine

[0019] SD rats (200-250 g) were injected with 50 μl of 10% phenol (dissolved in normal saline) to the lower pole of the left kidney to induce renal hypertension. After the animal's blood pressure rises to a stable level (about 15 days), a single intravenous injection of different doses of evodiamine is administered, and the changes in the mean arterial pressure are recorded after administration.

[0020] The experiment was divided into: (1) hypertension group; (2) different doses of evodiamine groups (30, 100, 300 μg / kg, iv); (3) Capsazepine (1.5 mg / kg, iv) + evodiamine (300 μg / kg, iv); kg) group; (4) capsaicin (50mg / kg, sc)+evodiamine (300μg / kg) group; (5) evodiamine vehicle (20% DMSO+80% ethanol) group; (6 ) capsaicin vehicle (10% ethanol + 10% Tween-80 + 80% saline) + evodiamine (300 μg / kg) group. Capsazepine is a selective capsaicin rece...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a blood pressure lowering medicine which comprises rutaecarpine and its pharmaceutically acceptable auxiliary agents. The medicament can keep long-period and stabilized blood pressure reducing action.

Description

Technical field [0001] The present invention relates to drugs for lowering blood pressure. Background technique [0002] Evodia rutaecarpa is a traditional Chinese medicine, which was first recorded in "Shen Nong's Materia Medica", and has been used clinically for hundreds of years. In recent years, domestic and foreign scholars have conducted in-depth research on its chemical composition and pharmacological effects. The important alkaloid components are evodiamine (Evo) and rutaecarpine (Rut). Evo and Rut can enhance the contractility of isolated guinea pig atrium and increase its contraction frequency. This effect can be induced by competitive capsaicin receptors (VR 1 ) antagonist Capsazepine and noncompetitive VR 1 Antagonist ruthenium red and selective calcitonin gene-related peptide (CGRP) receptor antagonist CGRP 8-37 and the two alkaloids can produce rapid cross-tolerance with capsaicin, suggesting that the excitatory effects of Evo and Rut on isolated guinea pi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P9/12
Inventor 李元建胡长平胡高云邓盘月谭桂山
Owner 李元建
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com