Method for detecting blood sugar-lowering and blood pressure-lowering drugs in blood by ultra high performance liquid-mass spectrometry
A technology of ultra-high performance liquid chromatography and mass spectrometry, which is applied in the field of detection of hypoglycemic and hypotensive drugs in blood by ultra-high performance liquid chromatography-mass spectrometry, which can solve the problems of limited detection time, complicated extraction process, and small amount of biological samples
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Embodiment 1
[0134] Embodiment 1 establishes the detection method of hypoglycemic and antihypertensive drugs in blood
[0135] 1.1 Establishment of detection target compounds and basic properties of compounds
[0136] See Table 6 for the chemical properties of 31 commonly used antihypertensive and hypoglycemic drugs; see Tables 7-1 and 7-2 for drug indications, adverse reactions, metabolic half-lives reported in literature, minimum detection limits, and minimum quantification limits.
[0137] Table 6 List of chemical properties of target compounds
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[0143] Table 7-1, half-life, minimum detection limit, and minimum quantification limit of 31 drugs
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[0147] Table 6-2, List of indications and adverse reactions of 31 drugs
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[0150] 1.2 Establishment of target compound detection instrument method
[0151] 1.2.1 Establishment of UPLC-MS / MS detection method
[0152] 1.2.1.1 ...
Embodiment 2
[0184] Example 2 Application of blood sugar-lowering and antihypertensive drug detection method
[0185] In order to test the accuracy of the ultra-high performance liquid chromatography-mass spectrometry method established in Example 1 to detect the results of hypoglycemic and antihypertensive drugs in blood samples, we collected blood samples from 14 cases of clinical patients in Civil Aviation Hospital. Antihypertensive and hypoglycemic drugs UPLC-MS / MS detection method was used to screen and detect hypoglycemic and antihypertensive drugs. The results are shown in Table 8.
[0186] Table 8. Detection table of hypoglycemic and hypotensive drugs in the blood of clinical patients
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[0189] From the above results, it can be seen that the test results are basically consistent with the information on the medication prescribed by the doctor, indicating that the established liquid chromatography-mass spectrometry method for the detection of hypoglycemic and ...
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